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Title:
COMPOSITION COMPRISING FRUCTOOLIGOSACCHARIDE AND QUERCETIN GLYCOSIDE
Document Type and Number:
WIPO Patent Application WO/2014/175180
Kind Code:
A1
Abstract:
A quercetin glycoside and a fructooligosaccharide in a ratio (by weight) of 1 to at least 0.1 are incorporated to produce a quercetin glycoside-containing oral composition and to mitigate the bitterness of the quercetin glycoside contained therein.

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Inventors:
SATOU YOUSUKE (JP)
TSUJIMOTO AKI (JP)
Application Number:
PCT/JP2014/061045
Publication Date:
October 30, 2014
Filing Date:
April 18, 2014
Export Citation:
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Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A61K31/7048; A23L1/30; A61K9/14; A61K9/20; A61K31/702; A61K36/00; A61K36/18; A61K36/28; A61K36/899; A61K47/26; A61P1/00; A61P1/02; A61P1/04; A61P1/10; A61P1/14; A61P1/16; A61P3/00; A61P3/02; A61P3/04; A61P3/06; A61P3/08; A61P7/06; A61P35/00; A61P39/06
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Other References:
GRZELAK, KATARZYNA ET AL.: "Content of quercetin glycosides and fructooligosaccharides in onion stored in a cold room", EUR FOOD RES TECHNOL, vol. 228, no. 6, 2009, pages 1001 - 1007, XP019702938
PHUWAMONGKOLWIWAT, PANCHITA ET AL.: "Fructooligosaccharides (FOS) enhance beneficial effects of a flavonoid, quercetin-3-glucoside (Q3G), on insulin sensitivity in rats fed high sucrose diet", THE FASEB JOURNAL, vol. 26, 2012, XP055298297, Retrieved from the Internet [retrieved on 20140603]
JUSKIEWICZ, JERZY ET AL.: "Consumption of polyphenol concentrate with dietary fructo- oligosaccharides enhances cecal metabolism of quercetin glycosides in rats", NUTRITION, vol. 27, no. 3, 2011, pages 351 - 357, XP028141695
NORIKO MATSUKAWA ET AL.: "Feedings of nondigestible saccharides promote bioavailability of quercetin glucosides with suppression of degrading luminal quercetin aglycone in rats", JOURNAL OF JAPANESE ASSOCIATION FOR DIETARY FIBER RESEARCH, vol. 13, no. 2, 2009, pages 97 - 106, XP055298356, Retrieved from the Internet [retrieved on 20140603]
MATSUKAWA, NORIKO ET AL.: "Nondigestible Saccharides Suppress the Bacterial Degradation of Quercetin Aglycone in the Large Intestine and Enhance the Bioavailability of Quercetin Glucoside in Rats", J. AGRIC. FOOD CHEM., vol. 57, no. 20, 2009, pages 9462 - 9468, XP055289877
MATSUKAWA, NORIKIO ET AL.: "Oligosaccharide Promotes Bioavailability of a Water-Soluble Flavonoid Glycoside, aG-Rutin", RATS, J. AGRIC. FOOD CHEM., vol. 57, no. 4, 2009, pages 1498 - 1505, XP055298252
See also references of EP 2990042A4
MOLECULAR AND CELLULAR BIOCHEMISTRY, vol. 243, 2003, pages 153 - 160
Attorney, Agent or Firm:
ONO, Shinjiro et al. (JP)
Ono Shinjiro (JP)
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