Title:
COMPOSITION COMPRISING FUSION PROTEIN OF RV2299C AND ESAT-6 FOR PROMOTING MATURATION OF DENDRITIC CELL
Document Type and Number:
WIPO Patent Application WO/2017/213407
Kind Code:
A1
Abstract:
The present invention relates to a composition for inducing dendritic cell maturation and a method for maturing dendritic cells. More particularly, the present invention relates to a composition comprising a fusion protein of Rv2299c and ESAT-6, both derived from M. tuberculosis, as an effective ingredient for inducing dendritic cell maturation, and a method for differentiating immature dendritic cells into dendritic cells by using the same. The method of the present invention can increase a dendritic cell immune response in the body.
Inventors:
KIM HWA-JUNG (KR)
CHOI HAN-GYU (KR)
SHIN SUNG-JAE (KR)
CHOI HAN-GYU (KR)
SHIN SUNG-JAE (KR)
Application Number:
PCT/KR2017/005892
Publication Date:
December 14, 2017
Filing Date:
June 07, 2017
Export Citation:
Assignee:
THE INDUSTRY & ACADEMIC COOPERATION IN CHUNGNAM NATIONAL UNIV (IAC) (KR)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
INDUSTRY-ACADEMIC COOPERATION FOUNDATION YONSEI UNIV (KR)
International Classes:
C12N5/0784; A61K38/16; C07K14/35
Foreign References:
| KR20130039061A | 2013-04-19 | |||
| KR20130081715A | 2013-07-17 | |||
| US8273357B2 | 2012-09-25 | |||
| KR20130012455A | 2013-02-04 |
Other References:
MARONGIU, LAURA ET AL.: "ESAT-6 and HspX Improve the Effectiveness of BCG to Induce Human Dendritic Cells-dependent Thl and NK Cells Activation", PLOS ONE, vol. 8, no. 10, 9 October 2013 (2013-10-09), pages 1 - 11, XP055556703
See also references of EP 3467102A4
See also references of EP 3467102A4
Attorney, Agent or Firm:
HWANG MOK PARK IP GROUP (KR)
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