Title:
COMPOSITION COMPRISING GLP-1 RECEPTOR AGONIST AND GLUCAGON RECEPTOR AGONIST AND APPLICATION THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/114425
Kind Code:
A1
Abstract:
The present invention provides a composition comprising a GLP-1 receptor agonist and a glucagon receptor agonist and an application of the composition. More specifically, the present invention provides a pharmaceutical composition comprising a pharmaceutically effective amount of the GLP-1 receptor agonist and the glucagon receptor agonist, wherein the GLP-1 receptor agonist and the glucagon receptor agonist independently form a conjugate with a hydrophilic polymer, or the GLP-1 receptor agonist and the glucagon receptor agonist jointly form a conjugate with the hydrophilic polymer.
Inventors:
XU MIN (CN)
LV WEI (CN)
ZHANG YINGHUI (CN)
LUO XIAOSU (CN)
LV WEI (CN)
ZHANG YINGHUI (CN)
LUO XIAOSU (CN)
Application Number:
PCT/CN2016/112674
Publication Date:
July 06, 2017
Filing Date:
December 28, 2016
Export Citation:
Assignee:
PEGBIO CO LTD (CN)
International Classes:
A61K38/17; A61K45/06; A61K38/26; A61K47/60; A61P1/16; A61P3/04; A61P3/06; A61P3/10
Foreign References:
| CN104902920A | 2015-09-09 | |||
| CN103338790A | 2013-10-02 |
Other References:
CLEMMENSEN, C. ET AL.: "GLP-1/Glucagon Coagonism Restores Leptin Responsiveness in Obese Mice Chronically Maintained on an Obesogenic Diet", DIABETES, vol. 63, no. 4, 30 April 2014 (2014-04-30), pages 1422 - 1427, XP055395929
PATEL, V. ET AL.: "Co-Agonist of Glucagon and GLP-1 Reduces Cholesterol and Improves Insulin Sensitivity Independent of its Effect on Appetite and Body Weight in Diet-Induced Obese C57 Mice", CANADIAN JOURNAL PHYSIOL PHARMACOL, vol. 91, no. 12, 31 December 2013 (2013-12-31), pages 1009 - 1015
PATEL, V. ET AL.: "Co-Agonist of Glucagon and GLP-1 Reduces Cholesterol and Improves Insulin Sensitivity Independent of its Effect on Appetite and Body Weight in Diet-Induced Obese C57 Mice", CANADIAN JOURNAL PHYSIOL PHARMACOL, vol. 91, no. 12, 31 December 2013 (2013-12-31), pages 1009 - 1015
Attorney, Agent or Firm:
UNITALEN ATTORNEYS AT LAW (CN)
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