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Title:
COMPOSITION COMPRISING HAIR TELOGEN- OR CATAGEN-INDUCING AGENT FOR PREVENTING AND ALLEVIATING ALOPECIA CAUSED BY ANTICANCER THERAPY
Document Type and Number:
WIPO Patent Application WO/2013/100459
Kind Code:
A1
Abstract:
Disclosed is a pharmaceutical composition comprising one or more hair telogen- and/or catagen-inducing agents for preventing and alleviating alopecia caused by anticancer chemotherapy and radiotherapy. Also disclosed is a method for preventing and alleviating alopecia caused by anticancer chemotherapy and radiotherapy, said method comprising a step of topically administrating one or more hair anagen- and/or catagen-inducing agents into the scalp of a patient in an effective dosage for prevention, alleviation or treatment. Further disclosed is a method for preventing and alleviating alopecia due to anticancer chemotherapy and radiotherapy by inducing a hair growth cycle through anagen and/or catagen. The composition and method according to the present invention can reduce dystrophy of hair caused by anticancer chemotherapy and radiotherapy to thereby reduce alopecia which is a side effect, and also facilitate the primary recovery of hair after alopecia. Therefore, the composition of the present invention can maximize therapeutic effects by preventing and/or repressing alopecia caused by side effects, when used together with cancer therapy to improve the quality of life of patients and encourage patients to actively participate in cancer therapy.

Inventors:
KWON OH SANG (KR)
KIM KYU HAN (KR)
EUN HEE CHUL (KR)
CHUNG JIN HO (KR)
PAIK SEUNG HWAN (KR)
Application Number:
KR2012/010983
Publication Date:
July 04, 2013
Filing Date:
December 17, 2012
Export Citation:
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Assignee:
SNU R&DB FOUNDATION (KR)
International Classes:
A61K31/573; A61P17/14; A61P35/00
Foreign References:
KR20100029634A2010-03-17
US5486509A1996-01-23
KR20050081424A2005-08-19
KR20100097574A2010-09-03
KR20100117198A2010-11-03
Other References:
HOFFMANN R. ET AL.: "Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata.", ARCH. DERMATOL. RES., vol. 288, 1996, pages 153 - 156
DANILENKO D. M. ET AL.: "Growth factors and cytokines in hair follicle development and cycling: recent insights from animal models and the potentials for clinical therapy.", MOLECULAR MEDICINE TODAY., vol. 2, no. 11, November 1996 (1996-11-01), pages 460 - 467
BOTCHKAREVN V. A. ET AL.: "Molecular Control of Epithelial-Mesenchymal Interactions During Hair Follicle Cycling.", JOURNAL OF INVESTIGATIVE DERMATOLOGY SYMPOSIUM PROCEEDINGS., vol. 8, no. 1, June 2003 (2003-06-01), pages 46 - 55
Attorney, Agent or Firm:
PARK, Weonmee (412 Nonhyeon-roGangnam-gu, Seoul 138-715, KR)
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Claims: