COMPOSITION COMPRISING HYPOTHEMYCIN AS ACTIVE INGREDIENT FOR PREVENTING AND TREATING MACROPHAGE ACTIVATION SYNDROME, HEPATOCIRRHOSIS, OR OBESITY

WIPO Patent Application WO/2013/187575

A1

The present invention relates to a pharmaceutical composition or health food comprising hypothemycin as an active ingredient for preventing and treating macrophage activation syndrome, hepatocirrhosis, or obesity. More particularly, since hypothemycin according to the present invention inhibits the production of TNF-α and the expression of TNF-α mRNA caused by activated macrophages, hypothemycin can be effectively used as an active ingredient for a pharmaceutical composition or health food for preventing and treating macrophage activation syndrome, hepatocirrhosis, or obesity, which are diseases induced by activated macrophages.

KANG JONG SOON (KR)
PARK KEE HWAN (KR)
LEE CHANG WOO (KR)
KIM HYOUNG-CHIN (KR)
OH SOO JIN (KR)
YUN JI EUN (KR)

PCT/KR2013/001376

December 19, 2013

February 21, 2013

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KOREA RES INST OF BIOSCIENCE (KR)

A61K31/336; A61K31/335; A61P3/00; A61P3/04

US20100004234A1	2010-01-07
US20040243224A1	2004-12-02

BAK, GI HWAN: "Decrease of TNF-alpha mRNA stability by hypothemycin", GRADUATE SCHOOL OF CHUNGBUK NATIONAL UNIVERSITY, MASTER'S DEGREE, February 2012 (2012-02-01)
CAMACHO ET AL.: "Hypothemycin inhibits the proliferative response and modulates the production of cytokines during T cell activation", IMMUNOPHARMACOLOGY, vol. 44, 1999, pages 255 - 265
TANAKA ET AL.: "Antitumor efficacy of hypothemycin, a new ras-signaling inhibitor", JAPANESE JOURNAL OF CANCER RESEARCH, vol. 90, 1999, pages 1139 - 1145

LEE, Won Hee (642-16Yoksam-dong,Kangnam-ku, Seoul 135-080, KR)

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