Title:
COMPOSITION COMPRISING LACTOBACILLUS
INTESTINALIS FOR PREVENTION OR TREATMENT OF CLIMACTERIC SYMPTOM
Document Type and Number:
WIPO Patent Application WO/2018/030838
Kind Code:
A1
Abstract:
The present invention relates to a novel Lactobacillus intestinalis YT2 strain (accession No: KCCM11812P) and a composition comprising Lactobacillus intestinalis inclusive of the novel strain as an effective ingredient for prevention, alleviation, or treatment of climacteric symptoms. The present inventors established a menopausal animal model by oophorectomy, detected a change in gut microbiota composition therefrom, identified and separated a novel Lactobacillus intestinalis strain among lactic acid bacteria which were significantly decreased in ratio in the microbiota composition of the menopausal model, and examined alleviative effects of the novel strain and conventionally reported Lactobacillus intestinalis strains on climacteric symptoms, such as suppression of increase in body fat, decreases in bone density, and increase in pain sensitivity, and alleviation of depression. The composition comprising Lactobacillus intestinalis according to the present invention is expected to be useful for prevention, alleviation or treatment of climacteric symptoms.
Inventors:
NAM YOUNG DO (KR)
KIM YUN TAI (KR)
SHIN HEE SOON (KR)
LEE SO YOUNG (KR)
KIM JAE GOO (KR)
LIM EUN YEONG (KR)
SONG EUN JI (KR)
KIM YUN TAI (KR)
SHIN HEE SOON (KR)
LEE SO YOUNG (KR)
KIM JAE GOO (KR)
LIM EUN YEONG (KR)
SONG EUN JI (KR)
Application Number:
PCT/KR2017/008738
Publication Date:
February 15, 2018
Filing Date:
August 11, 2017
Export Citation:
Assignee:
KOREA FOOD RES INST (KR)
International Classes:
C12N1/20; A23L33/135; A61K8/99; A61K35/747; A61Q19/00; C12R1/23
Foreign References:
| KR101279852B1 | 2013-07-09 |
Other References:
PARVANEH, KOLSOOM: "Effect of probiotics supplementation on bone mineral content and bone mass density", THE SCIENTIFIC WORLD JOURNAL, 22 January 2014 (2014-01-22), pages 1 - 6, XP055603326, ISSN: 2356-6140, DOI: 10.1155/2014/595962
LI, JAU-YI: "Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 126, no. 6, 12 June 2016 (2016-06-12), pages 2049 - 2063, XP055603335, ISSN: 0021-9738, DOI: 10.1172/JCI86062
BRITTON, ROBERT A. ET AL.: "Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 229, 27 March 2014 (2014-03-27), pages 1822 - 1830, XP055264927, DOI: doi:10.1002/jcp.24636
LECOMTE, VIRGINIE: "Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters", PLOS ONE, vol. 10, no. 5, 18 May 2015 (2015-05-18), pages 1 - 22, XP055439774
THE EFFECTS OF PROBIOTICS ON MENOPAUSAL SYMPTOMS IN OVARIECTOMIZED RATS, February 2017 (2017-02-01), pages 1 - 67
6 February 2017 (2017-02-06), pages 1 - 3, Retrieved from the Internet
LI, JAU-YI: "Sex steroid deficiency-associated bone loss is microbiota dependent and prevented by probiotics", THE JOURNAL OF CLINICAL INVESTIGATION, vol. 126, no. 6, 12 June 2016 (2016-06-12), pages 2049 - 2063, XP055603335, ISSN: 0021-9738, DOI: 10.1172/JCI86062
BRITTON, ROBERT A. ET AL.: "Probiotic L. reuteri treatment prevents bone loss in a menopausal ovariectomized mouse model", JOURNAL OF CELLULAR PHYSIOLOGY, vol. 229, 27 March 2014 (2014-03-27), pages 1822 - 1830, XP055264927, DOI: doi:10.1002/jcp.24636
LECOMTE, VIRGINIE: "Changes in gut microbiota in rats fed a high fat diet correlate with obesity-associated metabolic parameters", PLOS ONE, vol. 10, no. 5, 18 May 2015 (2015-05-18), pages 1 - 22, XP055439774
THE EFFECTS OF PROBIOTICS ON MENOPAUSAL SYMPTOMS IN OVARIECTOMIZED RATS, February 2017 (2017-02-01), pages 1 - 67
6 February 2017 (2017-02-06), pages 1 - 3, Retrieved from the Internet
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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