Title:
COMPOSITION COMPRISING LIPOPOLYSACCHARIDE
Document Type and Number:
WIPO Patent Application WO/2024/058253
Kind Code:
A1
Abstract:
The objective of the present invention is to provide a composition comprising an LPS of a Gram-negative bacterium having a predetermined structure or a predetermined activity. According to the present invention, provided is a composition comprising a lipopolysaccharide of a Gram-negative bacterium, wherein the lipopolysaccharide has lipid A, and the lipid A has a predetermined structure and a predetermined limulus activity.
Inventors:
KUWAHARA DAICHI (JP)
Application Number:
PCT/JP2023/033603
Publication Date:
March 21, 2024
Filing Date:
September 14, 2023
Export Citation:
Assignee:
ENEOS CORP (JP)
International Classes:
C12P19/04; C07H13/06
Foreign References:
| JPH08198902A | 1996-08-06 |
Other References:
TAKU ISHIBASHI: ",S01 Uses and functions of natural astaxanthin produced by fermentation method, ", PUBLIC INTEREST INCORPORATED ASSOCIATION, JAPAN AGRICULTURAL CHEMISTRY SOCIETY, CHUBU BRANCH, JAPAN AGRICULTURAL CHEMISTRY SOCIETY, CHUBU BRANCH, 181ST REGULAR MEETING LECTURE ABSTRACTS, 1 December 2017 (2017-12-01), XP093146509
WILKINSON, B.J. ; HINDAHL, M.S. ; GALBRAITH, L. ; WILKINSON, S.G.: "Lipopolysaccharide of Paracoccus denitrificans ATCC13543", FEMS MICROBIOLOGY LETTERS, NO LONGER PUBLISHED BY ELSEVIER, vol. 37, no. 1, 1 October 1986 (1986-10-01), pages 63 - 67, XP025957858, ISSN: 0378-1097, DOI: 10.1111/j.1574-6968.1986.tb01767.x
OKAHASHI NOBUYUKI, UEDA MASAHIRO, MATSUDA FUMIO, ARITA MAKOTO: "Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry", METABOLITES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, vol. 11, no. 4, 26 March 2021 (2021-03-26), pages 197, XP093146512, ISSN: 2218-1989, DOI: 10.3390/metabo11040197
KUSUMOTO SHOICHI, FUKASE KOICHI, FUKASE YOSHIYUKI, KATAOKA MIKAYO, YOSHIZAKI HIROAKI, SATO KENJIRO, OIKAWA MASATO, SUDA YASUO: "Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs", JOURNAL OF ENDOTOXIN RESEARCH, vol. 9, no. 6, 1 December 2003 (2003-12-01), UK , pages 361 - 366, XP009553633, ISSN: 0968-0519, DOI: 10.1177/09680519030090060901
MASAHIRO NISHIJIMA: "Research on elucidation of endotoxin recognition and stimulus transmission mechanisms and medical applications", 2ND FIELD. ASSIGNMENT NO. KH21021. 2006 REPORT., 1 January 2007 (2007-01-01), pages 143 - 148, XP093146514
TAKADA H, ET AL.: "STRUCTURAL REQUIREMENTS OF LIPID A SPECIES IN ACTIVATION OF CLOTTING ENZYMES FROM THE HORSESHOE CRAB, AND THE HUMAN COMPLEMENT CASCADE", EUROPEAN JOURNAL OF BIOCHEMISTRY, PUBLISHED BY SPRINGER-VERLAG ON BEHALF OF THE FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES, HOBOKEN, USA, vol. 175, no. 03, 1 January 1988 (1988-01-01), Hoboken, USA, pages 573 - 580, XP009032269, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1988.tb14230.x
WILKINSON, B.J. ; HINDAHL, M.S. ; GALBRAITH, L. ; WILKINSON, S.G.: "Lipopolysaccharide of Paracoccus denitrificans ATCC13543", FEMS MICROBIOLOGY LETTERS, NO LONGER PUBLISHED BY ELSEVIER, vol. 37, no. 1, 1 October 1986 (1986-10-01), pages 63 - 67, XP025957858, ISSN: 0378-1097, DOI: 10.1111/j.1574-6968.1986.tb01767.x
OKAHASHI NOBUYUKI, UEDA MASAHIRO, MATSUDA FUMIO, ARITA MAKOTO: "Analyses of Lipid A Diversity in Gram-Negative Intestinal Bacteria Using Liquid Chromatography–Quadrupole Time-of-Flight Mass Spectrometry", METABOLITES, MOLECULAR DIVERSITY PRESERVATION INTERNATIONAL, vol. 11, no. 4, 26 March 2021 (2021-03-26), pages 197, XP093146512, ISSN: 2218-1989, DOI: 10.3390/metabo11040197
KUSUMOTO SHOICHI, FUKASE KOICHI, FUKASE YOSHIYUKI, KATAOKA MIKAYO, YOSHIZAKI HIROAKI, SATO KENJIRO, OIKAWA MASATO, SUDA YASUO: "Structural basis for endotoxic and antagonistic activities: investigation with novel synthetic lipid A analogs", JOURNAL OF ENDOTOXIN RESEARCH, vol. 9, no. 6, 1 December 2003 (2003-12-01), UK , pages 361 - 366, XP009553633, ISSN: 0968-0519, DOI: 10.1177/09680519030090060901
MASAHIRO NISHIJIMA: "Research on elucidation of endotoxin recognition and stimulus transmission mechanisms and medical applications", 2ND FIELD. ASSIGNMENT NO. KH21021. 2006 REPORT., 1 January 2007 (2007-01-01), pages 143 - 148, XP093146514
TAKADA H, ET AL.: "STRUCTURAL REQUIREMENTS OF LIPID A SPECIES IN ACTIVATION OF CLOTTING ENZYMES FROM THE HORSESHOE CRAB, AND THE HUMAN COMPLEMENT CASCADE", EUROPEAN JOURNAL OF BIOCHEMISTRY, PUBLISHED BY SPRINGER-VERLAG ON BEHALF OF THE FEDERATION OF EUROPEAN BIOCHEMICAL SOCIETIES, HOBOKEN, USA, vol. 175, no. 03, 1 January 1988 (1988-01-01), Hoboken, USA, pages 573 - 580, XP009032269, ISSN: 0014-2956, DOI: 10.1111/j.1432-1033.1988.tb14230.x
Attorney, Agent or Firm:
KOBAYASHI Hiroshi et al. (JP)
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