Title:
COMPOSITION COMPRISING MIQUELIANIN AS EFFECTIVE INGREDIENT FOR PREVENTING OR TREATING TH2-MEDIATED IMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/045286
Kind Code:
A3
Abstract:
The present invention relates to a composition comprising miquelianin as an effective ingredient for preventing, alleviating, or treating Th2-mediated immune diseases. A composition according to the present invention was found to have an excellent anti-allergic effect. In greater detail, miquelianin was identified to restrain the generation of interleukin-2 (IL-2), interleukin-4 (IL-4), interleukin-5 (IL-5), and/or interleukin-13 (IL-13) as tested for anti-allergic effect in vivo and ex vivo. Also, miquelianin was found to have the effect of producing IgE and preventing T cell proliferation. Therefore, the composition according to the present invention is expected to find useful applications in the development of a therapeutic agent, a health functional food, and a cosmetic product for prevention, alleviation, or treatment of Th2-mediated immune diseases.
Inventors:
SHIN HEE SOON (KR)
LEE SO-YOUNG (KR)
PARK SO-LIM (KR)
NAM YOUNG-DO (KR)
SEO DONG-HO (KR)
EOM JI EUN (KR)
CHOI DAE WOON (KR)
SHIN DONG UK (KR)
JUNG SUN YOUNG (KR)
SHON DONG-HWA (KR)
YEON SUNG HUM (KR)
SON RAK HO (KR)
PIL GAM BANG (KR)
LEE SO-YOUNG (KR)
PARK SO-LIM (KR)
NAM YOUNG-DO (KR)
SEO DONG-HO (KR)
EOM JI EUN (KR)
CHOI DAE WOON (KR)
SHIN DONG UK (KR)
JUNG SUN YOUNG (KR)
SHON DONG-HWA (KR)
YEON SUNG HUM (KR)
SON RAK HO (KR)
PIL GAM BANG (KR)
Application Number:
PCT/KR2018/008664
Publication Date:
April 18, 2019
Filing Date:
July 31, 2018
Export Citation:
Assignee:
KOREA FOOD RES INST (KR)
HUONS CO LTD (KR)
HUONS CO LTD (KR)
International Classes:
A61K31/7048; A23L33/10; A61K8/60; A61Q19/00
Foreign References:
| EP2229940A1 | 2010-09-22 | |||
| KR20160101732A | 2016-08-26 | |||
| KR20160057716A | 2016-05-24 |
Other References:
MLCEK, J. ET AL.: "Quercetin and Its Anti-allergic Immune Response", MOLECULES, vol. 21, no. 5, 2016, pages 1 - 15, XP055594226
MAKINO, T. ET AL.: "Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice", JOURNAL OF NATURAL MEDICINES, vol. 67, 2013, pages 881 - 886, XP055594228
MAKINO, T. ET AL.: "Anti-allergic effects of enzymatically modified isoquercitrin (α-oligoglucosyl quercetin 3-O-glucoside), quercetin 3-O-glucoside, α-oligoglucosyl rutin, and quercetin, when administered orally to mice", JOURNAL OF NATURAL MEDICINES, vol. 67, 2013, pages 881 - 886, XP055594228
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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