Title:
COMPOSITION COMPRISING MLS-STAT3 FOR PREVENTION OR TREATMENT OF IMMUNE DISEASE
Document Type and Number:
WIPO Patent Application WO/2020/159191
Kind Code:
A1
Abstract:
The present invention relates to: a recombinant peptide in which a Mitochondria Localization Sequence (MLS) peptide and the Signal Transducer and Activator of Transcription 3 (STAT3) are fused to each other; a recombinant vector carrying a polynucleotide coding for the recombinant peptide; and a composition comprising the recombinant peptide or the recombinant vector as an active ingredient for prevention or treatment of autoimmune disease or inflammatory disease, wherein the recombinant peptide or the recombinant vector allows STAT3 to be overexpressed in the mitochondria to enhance the mitochondrial function, resulting in inhibiting the expression of inflammatory cytokines including IL-17, whereby the composition can be advantageously used for preventing or treating autoimmune disease or inflammatory diseases.
Inventors:
CHO MI-LA (KR)
PARK SUNG-HWAN (KR)
LEE SEON-YEONG (KR)
MOON SU-JIN (KR)
KIM EUN-KYUNG (KR)
RYU JUN-GEOL (KR)
CHOI SI-YEONG (KR)
CHOI JEONG-WON (KR)
JUNG KYUNG-AH (KR)
LEE A-RAM (KR)
YANG CHUL-WOO (KR)
MOON JEONG-HYEON (KR)
PARK SUNG-HWAN (KR)
LEE SEON-YEONG (KR)
MOON SU-JIN (KR)
KIM EUN-KYUNG (KR)
RYU JUN-GEOL (KR)
CHOI SI-YEONG (KR)
CHOI JEONG-WON (KR)
JUNG KYUNG-AH (KR)
LEE A-RAM (KR)
YANG CHUL-WOO (KR)
MOON JEONG-HYEON (KR)
Application Number:
PCT/KR2020/001287
Publication Date:
August 06, 2020
Filing Date:
January 28, 2020
Export Citation:
Assignee:
THE CATHOLIC UNIV OF KOREA INDUSTRY-ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C07K14/47; A61K9/00; A61K38/17; A61K47/64; A61P29/00; A61P37/02; C12N15/62; C12N15/67
Foreign References:
| KR20180038156A | 2018-04-16 |
Other References:
WEGRZYN, J.: "Function of mitochondrial Stat3 in cellular respiration", SCIENCE, vol. 323, no. 5915, 6 February 2009 (2009-02-06), pages 793 - 797, XP055728048
RUI YANG, MERCEDES RINCON: "Mitochondrial Stat3, the need for design thinking", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCE, vol. 12, no. 5, 29 February 2016 (2016-02-29), pages 532 - 544, XP055728050
QIFANG ZHANG, VIDISHA RAJE, VASILY A. YAKOVLEV, ADLY YACOUB, KAROL SZCZEPANEK, JEREMY MEIER, MARTA DERECKA, QUN CHEN, YING HU, JEN: "Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 43, 25 October 2013 (2013-10-25), pages 31280 - 31288, XP055728055, DOI: 10.1074/jbc.M113.505057
KAROL SZCZEPANEK, QUN CHEN, MARTA DERECKA, FADI N. SALLOUM, QIFANG ZHANG, MAGDALENA SZELAG, JOANNA CICHY, RAKESH C. KUKREJA, JOZEF: "Mitochondrial-targeted signal transducer and activator of transcription 3(STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 34, 26 August 2011 (2011-08-26), pages 29610 - 29620, XP055728064, DOI: 10.1074/jbc.M111.226209
RUI YANG, MERCEDES RINCON: "Mitochondrial Stat3, the need for design thinking", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCE, vol. 12, no. 5, 29 February 2016 (2016-02-29), pages 532 - 544, XP055728050
QIFANG ZHANG, VIDISHA RAJE, VASILY A. YAKOVLEV, ADLY YACOUB, KAROL SZCZEPANEK, JEREMY MEIER, MARTA DERECKA, QUN CHEN, YING HU, JEN: "Mitochondrial localized Stat3 promotes breast cancer growth via phosphorylation of serine 727", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 288, no. 43, 25 October 2013 (2013-10-25), pages 31280 - 31288, XP055728055, DOI: 10.1074/jbc.M113.505057
KAROL SZCZEPANEK, QUN CHEN, MARTA DERECKA, FADI N. SALLOUM, QIFANG ZHANG, MAGDALENA SZELAG, JOANNA CICHY, RAKESH C. KUKREJA, JOZEF: "Mitochondrial-targeted signal transducer and activator of transcription 3(STAT3) protects against ischemia-induced changes in the electron transport chain and the generation of reactive oxygen species", THE JOURNAL OF BIOLOGICAL CHEMISTRY, vol. 286, no. 34, 26 August 2011 (2011-08-26), pages 29610 - 29620, XP055728064, DOI: 10.1074/jbc.M111.226209
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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