Title:
COMPOSITION COMPRISING OLEANOLIC ACID ACETATE AS ACTIVE INGREDIENT FOR PREVENTING, ALLEVIATING, OR TREATING RENAL TOXICITY INDUCED BY MEDICINE
Document Type and Number:
WIPO Patent Application WO/2018/066954
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising oleanolic acid acetate as an active ingredient for preventing, alleviating, or treating renal toxicity induced by a medicine. Specifically, the present invention relates to a pharmaceutical composition for preventing or treating renal toxicity induced by a medicine, the composition comprising oleanolic acid acetate or a pharmaceutically acceptable salt thereof as an active ingredient, to a health functional food comprising the active ingredient for preventing or alleviating renal toxicity induced by a medicine, and to an anticancer supplement comprising the active ingredient. The oleanolic acid acetate of the present invention is derived from a natural material, and thus has no side effect and no toxicity and has excellent effects of preventing, alleviating, and treating renal toxicity induced by a medicine, especially, a platinum-based anticancer agent, and therefore, the oleanolic acid acetate of the present invention can be utilized as a pharmaceutical composition, a health functional food, and an anticancer supplement therefor.
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Inventors:
RHO MUN CHUAL (KR)
LEE SEUNG WOONG (KR)
LEE SOYOUNG (KR)
KIM SANG-HYUN (KR)
PARK KWON MOO (KR)
LEE WOO SONG (KR)
JUNG KYUNGSOOK (KR)
PARK CHAN SUN (KR)
LEE SEUNG WOONG (KR)
LEE SOYOUNG (KR)
KIM SANG-HYUN (KR)
PARK KWON MOO (KR)
LEE WOO SONG (KR)
JUNG KYUNGSOOK (KR)
PARK CHAN SUN (KR)
Application Number:
PCT/KR2017/011044
Publication Date:
April 12, 2018
Filing Date:
September 29, 2017
Export Citation:
Assignee:
KOREA RES INST BIOSCIENCE & BIOTECHNOLOGY (KR)
International Classes:
A61K31/19; A23L33/10
Foreign References:
| KR20120124361A | 2012-11-13 | |||
| KR20070026898A | 2007-03-09 | |||
| KR20030082763A | 2003-10-23 | |||
| KR930021201A | 1993-11-22 | |||
| KR101737277B1 | 2017-05-18 |
Other References:
MANIΎA. P.J. ET AL.: "NEPHROPROTECTION BY OLEANOLIC AND URSOLIC ACID AGAINST CISPLATIN IS COMPARABLE TO AMIFOSTINE", WORLD JOURNAL OF PHARMACY AND PHARMACEUTICAL SCIENCES, vol. 3, no. 3, 2014, pages 1677 - 1686, XP055485808
See also references of EP 3524239A4
See also references of EP 3524239A4
Attorney, Agent or Firm:
AHN, So Young (KR)
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