Title:
COMPOSITION COMPRISING PROTEIN PHOSPHATASE 1 INHIBITORY PEPTIDE FOR TREATING VASCULAR DISEASES
Document Type and Number:
WIPO Patent Application WO/2018/080146
Kind Code:
A2
Abstract:
The present invention relates to a composition comprising a protein phosphatase 1 inhibitory peptide for treating vascular diseases. The composition of the present invention inhibits protein phosphatase 1 (PP1)-mediated dephosphorylation to suppress abnormal proliferation of vascular smooth muscle cells (VSMCs), and activates eNOS of vascular endothelial cells (VECs) to induce the recovery from dysfunction, and thus can be favorably used in the treatment of vascular diseases including pulmonary hypertension.
Inventors:
PARK WOO JIN (KR)
JANG SEUNG PIL (KR)
JANG SEUNG PIL (KR)
Application Number:
PCT/KR2017/011796
Publication Date:
May 03, 2018
Filing Date:
October 24, 2017
Export Citation:
Assignee:
GWANGJU INST SCIENCE & TECH (KR)
International Classes:
A61K38/08; A23L33/18
Foreign References:
| KR20160138612A | 2016-12-06 | |||
| KR101516791B1 | 2015-05-04 |
Other References:
PASTERKAMP G ET AL., CARDIOVASC RES, vol. 45, no. 4, 2000, pages 843 - 852
RABINOVITCH M ET AL., J CLIN INVEST, vol. 122, no. 12, 2012, pages 4306 - 4313
HARVEY A ET AL., CAN J CARDIOL, vol. 32, no. 5, 2016, pages 659 - 668
MICHELL GF, HYPERTENSION, vol. 64, no. 1, 2014, pages 13 - 18
DZAU VJ ET AL., NATURE MED, vol. 8, 2002, pages 1249 - 1256
NOVAK K ET AL., NATURE MED, vol. 4, 1998, pages 989 - 990
AUSTIN GE ET AL., J AM COLL CARDIOL, vol. 6, 1985, pages 369 - 375
HANKE H ET AL., HERZ, vol. 12, 1992, pages 300 - 308
HOEPER MM ET AL., ENGL J MED, vol. 342, 2000, pages 1866 - 1870
GIAID A ET AL., N ENGL J MED, vol. 328, 1993, pages 1732 - 1739
VALLOT 0 ET AL., AERTERIOSCLER THROMB VASE BIOL, vol. 20, 2000, pages 1225 - 1235
LIPSKAIA L ET AL., CIRC RES, vol. 97, 2005, pages 488 - 495
LIPSKAIA L ET AL., GENE THER, vol. 20, 2013, pages 396 - 406
STEENAART NA ET AL., ARCH BIOCHEM BIOPHYS, vol. 293, 1992, pages 17 - 24
MATTIAZZI A ET AL., CARDIOVASC RES, vol. 68, 2005, pages 366 - 375
SCHWINGER RH ET AL., J MOL CELL CARDIOL, vol. 31, 1999, pages 479 - 491
SANDE JB ET AL., CARDIOVASC RES, vol. 53, 2002, pages 382 - 391
OH JG ET AL., J MOL CELL CARDIOL, vol. 56, 2013, pages 63 - 71
GIAID A ET AL., N ENGL J MED, vol. 333, 1995, pages 214 - 221
CHRISTMAN BW ET AL., N ENGL J MED, vol. 327, 1992, pages 70 - 75
SIEHR SL ET AL., FRONT PEDIATR, vol. 3, 2015, pages 12
WEI L ET AL., HYPERTENS RES, vol. 36, no. 5, 2013, pages 414 - 421
GRANTON J ET AL., CIRC RES, vol. 117, no. 7, 2015, pages 645 - 654
SAWADA H ET AL., J EXP MED, vol. 211, no. 2, 2014, pages 263 - 280
SPIEKERKOETTER E ET AL., CIRC RES, vol. 105, 2009, pages 639 - 647
SPIEKERKOETTER E ET AL., RESPIR CRIT CARE MED, vol. 192, 2013, pages 254 - 257
JUNG MR ET AL., J CONTROL RELASE, vol. 152, no. 2, 2011, pages 294 - 302
LIM S ET AL., MOL CELLS, vol. 34, no. 6, 2012, pages 577 - 582
LIM S ET AL., PLOS ONE, vol. 11, no. 5, 2016, pages e0155689
LIM S ET AL., NAT COMMUN, vol. 6, 2015, pages 8244
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J MOL BIO, vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS MOL BIOL, vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC ACIDS RES, vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP APPL BIOSCI, vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH MOL BIOL, vol. 24, 1994, pages 307 - 31
MORRIS, M. C. ET AL., NATURE BIOTECHNOL., vol. 19, 2001, pages 1173 - 1176
DUPONT AJPROCHIANTZ A: "CRC Handbook on Cell Penetrating Peptides", 2002, CRC PRESS
CHALOIN, L. ET AL., BIOCHEMISTRY, vol. 36, no. 37, 1997, pages 11179 - 87
LUNDBERG PLANGEL U., J. MOL. RECOGNIT., vol. 16, no. 5, 2003, pages 227 - 233
BRUGIDOU J. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 214, no. 2, 1995, pages 685 - 93
DEROSSI D ET AL., TRENDS CELL BIOL., vol. 8, 1998, pages 84 - 87
"Remington's Pharmaceutical Sciences", 1995
SAIDO TC ET AL., FASEB J, vol. 8, 1994, pages 814 - 822
MATSUMURA Y ET AL., J MOL CELL CARDIOL, vol. 33, 2001, pages 1133 - 1142
ARIYOSHI H ET AL., ARTERIOSCLER THROMB VASE BIOL, vol. 18, 1998, pages 493 - 498
THOMPSON AA ET AL., TRENDS MOL MED, vol. 23, no. 1, 2017, pages 31 - 45
STENMARK KR ET AL., COMPR PHYSIOL, vol. 1, no. 1, 2011, pages 141 - 161
AIHARA K ET AL., INT J VASE MED, vol. 2012, 2012, pages 596796
GIAID ET AL., N ENGL J MED, vol. 333, 1995, pages 214 - 221
MICHELL BJ ET AL., CURR BIOL, vol. 9, no. 15, 1999, pages 845 - 848
LOU Q ET AL., ADV EXP MED BIOL, vol. 740, 2012, pages 1145 - 1174
HEIJMAN J ET AL., WIEN MED WOCHENSCHR, vol. 162, 2012, pages 287 - 291
MEYER M ET AL., CIRCULATION, vol. 92, 1995, pages 778 - 784
KHO C ET AL., NATURE, vol. 477, 2011, pages 601 - 605
MIYAMOTO MI ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 793 - 798
KAWASE Y ET AL., J AM COLL CARDIOL, vol. 51, 2008, pages 1112 - 1119
DEL MONTE F ET AL., CIRCULATION, vol. 104, 2001, pages 1424 - 1429
NICOLAOU P ET AL., J MOLL CELL CARDIOL, vol. 47, 2009, pages 365 - 371
LIPSKAIA L ET AL., CIRUCATION, vol. 129, 2014, pages 773 - 785
ZHAO Y ET AL., J PHARMACOL SCI, vol. 129, no. 2, 2015, pages 83 - 94
BLATTER LA ET AL., CELL CALCIUM, vol. 15, no. 2, 1994, pages 122 - 131
PRIOR DL ET AL., MED J AUST, vol. 205, no. 6, 2016, pages 271 - 276
See also references of EP 3530278A4
RABINOVITCH M ET AL., J CLIN INVEST, vol. 122, no. 12, 2012, pages 4306 - 4313
HARVEY A ET AL., CAN J CARDIOL, vol. 32, no. 5, 2016, pages 659 - 668
MICHELL GF, HYPERTENSION, vol. 64, no. 1, 2014, pages 13 - 18
DZAU VJ ET AL., NATURE MED, vol. 8, 2002, pages 1249 - 1256
NOVAK K ET AL., NATURE MED, vol. 4, 1998, pages 989 - 990
AUSTIN GE ET AL., J AM COLL CARDIOL, vol. 6, 1985, pages 369 - 375
HANKE H ET AL., HERZ, vol. 12, 1992, pages 300 - 308
HOEPER MM ET AL., ENGL J MED, vol. 342, 2000, pages 1866 - 1870
GIAID A ET AL., N ENGL J MED, vol. 328, 1993, pages 1732 - 1739
VALLOT 0 ET AL., AERTERIOSCLER THROMB VASE BIOL, vol. 20, 2000, pages 1225 - 1235
LIPSKAIA L ET AL., CIRC RES, vol. 97, 2005, pages 488 - 495
LIPSKAIA L ET AL., GENE THER, vol. 20, 2013, pages 396 - 406
STEENAART NA ET AL., ARCH BIOCHEM BIOPHYS, vol. 293, 1992, pages 17 - 24
MATTIAZZI A ET AL., CARDIOVASC RES, vol. 68, 2005, pages 366 - 375
SCHWINGER RH ET AL., J MOL CELL CARDIOL, vol. 31, 1999, pages 479 - 491
SANDE JB ET AL., CARDIOVASC RES, vol. 53, 2002, pages 382 - 391
OH JG ET AL., J MOL CELL CARDIOL, vol. 56, 2013, pages 63 - 71
GIAID A ET AL., N ENGL J MED, vol. 333, 1995, pages 214 - 221
CHRISTMAN BW ET AL., N ENGL J MED, vol. 327, 1992, pages 70 - 75
SIEHR SL ET AL., FRONT PEDIATR, vol. 3, 2015, pages 12
WEI L ET AL., HYPERTENS RES, vol. 36, no. 5, 2013, pages 414 - 421
GRANTON J ET AL., CIRC RES, vol. 117, no. 7, 2015, pages 645 - 654
SAWADA H ET AL., J EXP MED, vol. 211, no. 2, 2014, pages 263 - 280
SPIEKERKOETTER E ET AL., CIRC RES, vol. 105, 2009, pages 639 - 647
SPIEKERKOETTER E ET AL., RESPIR CRIT CARE MED, vol. 192, 2013, pages 254 - 257
JUNG MR ET AL., J CONTROL RELASE, vol. 152, no. 2, 2011, pages 294 - 302
LIM S ET AL., MOL CELLS, vol. 34, no. 6, 2012, pages 577 - 582
LIM S ET AL., PLOS ONE, vol. 11, no. 5, 2016, pages e0155689
LIM S ET AL., NAT COMMUN, vol. 6, 2015, pages 8244
SMITHWATERMAN, ADV. APPL. MATH., vol. 2, 1981, pages 482
NEEDLEMANWUNSCH, J MOL BIO, vol. 48, 1970, pages 443
PEARSONLIPMAN, METHODS MOL BIOL, vol. 24, 1988, pages 307 - 31
HIGGINSSHARP, GENE, vol. 73, 1988, pages 237 - 44
HIGGINSSHARP, CABIOS, vol. 5, 1989, pages 151 - 3
CORPET ET AL., NUC ACIDS RES, vol. 16, 1988, pages 10881 - 90
HUANG ET AL., COMP APPL BIOSCI, vol. 8, 1992, pages 155 - 65
PEARSON ET AL., METH MOL BIOL, vol. 24, 1994, pages 307 - 31
MORRIS, M. C. ET AL., NATURE BIOTECHNOL., vol. 19, 2001, pages 1173 - 1176
DUPONT AJPROCHIANTZ A: "CRC Handbook on Cell Penetrating Peptides", 2002, CRC PRESS
CHALOIN, L. ET AL., BIOCHEMISTRY, vol. 36, no. 37, 1997, pages 11179 - 87
LUNDBERG PLANGEL U., J. MOL. RECOGNIT., vol. 16, no. 5, 2003, pages 227 - 233
BRUGIDOU J. ET AL., BIOCHEM BIOPHYS RES COMMUN, vol. 214, no. 2, 1995, pages 685 - 93
DEROSSI D ET AL., TRENDS CELL BIOL., vol. 8, 1998, pages 84 - 87
"Remington's Pharmaceutical Sciences", 1995
SAIDO TC ET AL., FASEB J, vol. 8, 1994, pages 814 - 822
MATSUMURA Y ET AL., J MOL CELL CARDIOL, vol. 33, 2001, pages 1133 - 1142
ARIYOSHI H ET AL., ARTERIOSCLER THROMB VASE BIOL, vol. 18, 1998, pages 493 - 498
THOMPSON AA ET AL., TRENDS MOL MED, vol. 23, no. 1, 2017, pages 31 - 45
STENMARK KR ET AL., COMPR PHYSIOL, vol. 1, no. 1, 2011, pages 141 - 161
AIHARA K ET AL., INT J VASE MED, vol. 2012, 2012, pages 596796
GIAID ET AL., N ENGL J MED, vol. 333, 1995, pages 214 - 221
MICHELL BJ ET AL., CURR BIOL, vol. 9, no. 15, 1999, pages 845 - 848
LOU Q ET AL., ADV EXP MED BIOL, vol. 740, 2012, pages 1145 - 1174
HEIJMAN J ET AL., WIEN MED WOCHENSCHR, vol. 162, 2012, pages 287 - 291
MEYER M ET AL., CIRCULATION, vol. 92, 1995, pages 778 - 784
KHO C ET AL., NATURE, vol. 477, 2011, pages 601 - 605
MIYAMOTO MI ET AL., PROC NATL ACAD SCI USA, vol. 97, 2000, pages 793 - 798
KAWASE Y ET AL., J AM COLL CARDIOL, vol. 51, 2008, pages 1112 - 1119
DEL MONTE F ET AL., CIRCULATION, vol. 104, 2001, pages 1424 - 1429
NICOLAOU P ET AL., J MOLL CELL CARDIOL, vol. 47, 2009, pages 365 - 371
LIPSKAIA L ET AL., CIRUCATION, vol. 129, 2014, pages 773 - 785
ZHAO Y ET AL., J PHARMACOL SCI, vol. 129, no. 2, 2015, pages 83 - 94
BLATTER LA ET AL., CELL CALCIUM, vol. 15, no. 2, 1994, pages 122 - 131
PRIOR DL ET AL., MED J AUST, vol. 205, no. 6, 2016, pages 271 - 276
See also references of EP 3530278A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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