Title:
COMPOSITION COMPRISING RADIOACTIVE METAL AND EUROPIUM FOR PHOTODYNAMIC THERAPY
Document Type and Number:
WIPO Patent Application WO/2020/138805
Kind Code:
A1
Abstract:
A composition of the present invention comprises: a radio-labelled liposome encapsulating an Eu-DTPA complex and Victoria-blue BO therein; and a radioactive metal and as such, has high stability and excellent ability to generate reactive oxygen species in vivo. Therefore, the composition can exhibit excellent circulatory potential and target performance when used in photodynamic therapy.
Inventors:
IM HYUNG JUN (KR)
LEE WOO SEUNG (KR)
JEON MI YEON (KR)
CHOI JIN YEONG (KR)
OH CHI WOO (KR)
LEE WOO SEUNG (KR)
JEON MI YEON (KR)
CHOI JIN YEONG (KR)
OH CHI WOO (KR)
Application Number:
PCT/KR2019/017816
Publication Date:
July 02, 2020
Filing Date:
December 16, 2019
Export Citation:
Assignee:
SEOUL NAT UNIV R&DB FOUNDATION (KR)
International Classes:
A61K41/00; A61K47/54; A61K51/12
Foreign References:
| KR20060039451A | 2006-05-08 | |||
| KR20130013136A | 2013-02-06 | |||
| US20090028792A1 | 2009-01-29 |
Other References:
ORELLANA, A.: "Europium chelate-loaded liposomes : a tool for the study of binding and integrity of liposomes", BIOCHIMICA ET BIOPHYSICA ACTA, 1996, XP055724372
WAINWRIGHT, M.: "Uptake and cell -killing activities of a series of victoria blue derivatives in a mouse mammary tumor cell line", CYTOTECHNOLOGY, 1999
LEE, W.: "Preparation of radiolabeled europium loaded nanoparticle for in vivo imaging and gamma ray induced photodynamic therapy", THE JOURNAL OF NUCLEAR MEDICINE, 1 May 2019 (2019-05-01)
WAINWRIGHT, M.: "Uptake and cell -killing activities of a series of victoria blue derivatives in a mouse mammary tumor cell line", CYTOTECHNOLOGY, 1999
LEE, W.: "Preparation of radiolabeled europium loaded nanoparticle for in vivo imaging and gamma ray induced photodynamic therapy", THE JOURNAL OF NUCLEAR MEDICINE, 1 May 2019 (2019-05-01)
Attorney, Agent or Firm:
LEECHAE INTELLECTUAL PROPERTY (KR)
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