Title:
COMPOSITION, COMPRISING TONSIL-DERIVED MESENCHYMAL STEM CELL-CONTROLLING MEDIUM, FOR PREVENTION OR TREATMENT OF HEPATIC DISEASE
Document Type and Number:
WIPO Patent Application WO/2019/190218
Kind Code:
A1
Abstract:
The present invention relates to a composition comprising a tonsil-derived mesenchymal stem cell-controlling medium as an effective ingredient for prevention, alleviation, or treatment of hepatic diseases. The composition for prevention, alleviation, or treatment of hepatic diseases of the present invention exhibits different profiles for immunoregulatory elements and hepatic fibrosis inhibiting elements in the controlling medium in contrast with controlling media of mesenchymal stem cells derived from other tissues and, as a result, has excellent effects on the prevention, alleviation, and treatment of hepatic diseases.
Inventors:
RYU KYUNG HA (KR)
WOO SO YOUN (KR)
PARK JOO WON (KR)
JO IN HO (KR)
KIM HAN SU (KR)
CHO KYUNG AH (KR)
KIM YU HEE (KR)
PARK MIN HWA (KR)
WOO SO YOUN (KR)
PARK JOO WON (KR)
JO IN HO (KR)
KIM HAN SU (KR)
CHO KYUNG AH (KR)
KIM YU HEE (KR)
PARK MIN HWA (KR)
Application Number:
PCT/KR2019/003626
Publication Date:
October 03, 2019
Filing Date:
March 28, 2019
Export Citation:
Assignee:
UNIV EWHA IND COLLABORATION (KR)
International Classes:
A61K35/28; A23L33/10; A61P1/16
Foreign References:
| KR20140135367A | 2014-11-26 |
Other References:
GAZDIC, M . ET AL.: "Mesenchymal stem cell -dependent modulation of liver diseases", INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, vol. 13, no. 9, 2017, pages 1109 - 1117, XP055639366
CHO, K.-A.: "Conditioned media from human palatine tonsil mesenchymal stem cells regulates the interaction between myotubes and fibroblasts by 11-IRa activity", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 21, no. 1, 2017, pages 130 - 141, XP055639370
SANG, J.-F.: "Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 22, no. 16, 2016, pages 4120 - 4135, XP055639374
PARK, M.: "Tonsil-derived mesenchymal stem cells ameliorate CCI4-induced liver fibrosis in mice via autophagy activation", SCIENTIFIC REPORTS, vol. 5, 8616, 8 May 2015 (2015-05-08), pages 1 - 7, XP055639377
KIM, Y.-H.: "Conditioned medium from tonsil-derived mesenchymal stem cells relieves CC14-induced liver fibrosis in mice", TISSUE ENG. REGEN. MED., vol. 16, no. 1, 19 October 2018 (2018-10-19), pages 51 - 58, XP036694608
CHO, K.-A.: "Conditioned media from human palatine tonsil mesenchymal stem cells regulates the interaction between myotubes and fibroblasts by 11-IRa activity", JOURNAL OF CELLULAR AND MOLECULAR MEDICINE, vol. 21, no. 1, 2017, pages 130 - 141, XP055639370
SANG, J.-F.: "Combined mesenchymal stem cell transplantation and interleukin-1 receptor antagonism after partial hepatectomy", WORLD JOURNAL OF GASTROENTEROLOGY, vol. 22, no. 16, 2016, pages 4120 - 4135, XP055639374
PARK, M.: "Tonsil-derived mesenchymal stem cells ameliorate CCI4-induced liver fibrosis in mice via autophagy activation", SCIENTIFIC REPORTS, vol. 5, 8616, 8 May 2015 (2015-05-08), pages 1 - 7, XP055639377
KIM, Y.-H.: "Conditioned medium from tonsil-derived mesenchymal stem cells relieves CC14-induced liver fibrosis in mice", TISSUE ENG. REGEN. MED., vol. 16, no. 1, 19 October 2018 (2018-10-19), pages 51 - 58, XP036694608
Attorney, Agent or Firm:
KIM, Soon Woong (KR)
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