Title:
COMPOSITION CONTAINING ADIPOSE STEM CELL-DERIVED EXOSOMES AS ACTIVE INGREDIENT FOR PREVENTING OR TREATING LIVER FIBROSIS
Document Type and Number:
WIPO Patent Application WO/2018/093233
Kind Code:
A1
Abstract:
The present invention relates to a composition containing human adipose stem cell-derived exosomes as an active ingredient for preventing, alleviating or treating liver fibrosis. The adipose stem cell-derived exosomes according to the present invention carry genetic information, protein, growth factor and the like for treating liver fibrosis, and have shown excellent results in treating liver fibrosis in animal models therefor, and, being a cell-derived substance, exosomes have the advantages of being highly biocompatible and having a superb absorption rate. Accordingly, the limits of medicine in current use or adverse reactions that can arise due to cancerization of stem cells or cell waste products in treatments using stem cells themselves can be minimized, and the delivery to the liver can be natural via intravenous injection, local injection and the like which can be applied simply without surgery, thus economic cost can be reduced and stress on the patient can also be lessened. In conclusion, the adipose stem cell-derived exosomes according to the present invention are expected to be effectively used for preventing, alleviating and treating liver fibrosis.
Inventors:
PARK JAE HYUNG (KR)
LEE HANSANG (KR)
HEO ROUN (KR)
HAN HWA SEUNG (KR)
LEE HANSANG (KR)
HEO ROUN (KR)
HAN HWA SEUNG (KR)
Application Number:
PCT/KR2017/013255
Publication Date:
May 24, 2018
Filing Date:
November 21, 2017
Export Citation:
Assignee:
RESEARCH & BUSINESS FOUND SUNGKYUNKWAN UNIV (KR)
International Classes:
A61K35/28; A23L33/10
Foreign References:
| KR20160055827A | 2016-05-18 | |||
| KR101542849B1 | 2015-08-10 |
Other References:
HU , L. ET AL.: "Exosomes Derived from Human Adipose Mensenchymal Stem Cells Accelerates Cutaneous Wound Healing via Optimizing the Characteristics of Fibroblasts", SCIENTIFIC REPORTS, vol. 6, no. 32993, 2016, pages 1 - 1 1, XP055485849, [retrieved on 20160912]
LI, T. ET AL.: "Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis", STEM CELL AND DEVELOPMENT, vol. 22, no. 6, 2013, pages 845 - 854, XP055486470
JANG, Y. O. ET AL.: "Effect of Bone Marrow-derived Mesenchymal Stem Cells on Hepatic Fibrosis in a Thioacetamide-induced Cirrhotic Rat Model", BMC GASTROENTEROLOGY, vol. 14, no. 1, 2014, pages 198, XP021205828
MAROTE, A. ET AL.: "MSCs-derived Exosomes: Cell -secreted Nanovesicles with Regenerative Potential", FRONTIERS IN PHARMACOLOGY, vol. 7, no. 231, August 2016 (2016-08-01), pages 1 - 8, XP055486475
HARN, H.-J. ET AL.: "Adipose-derived Stem Cells Can Abrogate Chemical-induced Liver Fibrosis and Facilitate Recovery of Liver Function", CELL TRANSPLANTATION, vol. 21, 2012, pages 2753 - 2764, XP055486477
See also references of EP 3542806A4
HIEN T. T ET AL., SMALL, vol. 19, 2015, pages 2291 - 2304
LI, T. ET AL.: "Exosomes Derived from Human Umbilical Cord Mesenchymal Stem Cells Alleviate Liver Fibrosis", STEM CELL AND DEVELOPMENT, vol. 22, no. 6, 2013, pages 845 - 854, XP055486470
JANG, Y. O. ET AL.: "Effect of Bone Marrow-derived Mesenchymal Stem Cells on Hepatic Fibrosis in a Thioacetamide-induced Cirrhotic Rat Model", BMC GASTROENTEROLOGY, vol. 14, no. 1, 2014, pages 198, XP021205828
MAROTE, A. ET AL.: "MSCs-derived Exosomes: Cell -secreted Nanovesicles with Regenerative Potential", FRONTIERS IN PHARMACOLOGY, vol. 7, no. 231, August 2016 (2016-08-01), pages 1 - 8, XP055486475
HARN, H.-J. ET AL.: "Adipose-derived Stem Cells Can Abrogate Chemical-induced Liver Fibrosis and Facilitate Recovery of Liver Function", CELL TRANSPLANTATION, vol. 21, 2012, pages 2753 - 2764, XP055486477
See also references of EP 3542806A4
HIEN T. T ET AL., SMALL, vol. 19, 2015, pages 2291 - 2304
Attorney, Agent or Firm:
LEE, Myoung-Jin (KR)
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