Title:
COMPOSITION CONTAINING ARTEMISIA CAPILLARIS, SANGUISORBA OFFICINALIS, AND CURCUMA LONGA EXTRACTS AND ANTIVIRAL AGENT, AS ACTIVE INGREDIENTS, FOR PREVENTING OR TREATING LIVER DISEASE
Document Type and Number:
WIPO Patent Application WO/2017/183902
Kind Code:
A1
Abstract:
The present invention relates to a composition containing Artemisia capillaris,
Sanguisorba officinalis, and Curcuma longa extracts and an antiviral agent, as active ingredients, for preventing or treating liver disease. The co-administration of Artemisia capillaris, Sanguisorba officinalis, and Curcuma longa extracts and an antiviral agent for hepatitis B according to the present invention suppresses the hepatitis B virus e antigen and effectively inhibits the expression of inflammatory cytokine TNF-α, IL-1β, or TGF-β, so that the inhibition of cirrhosis or liver cancer as well as the treatment of hepatitis B can be expected.
Inventors:
KIM BUM-JOON (KR)
LEE JANG-HOON (KR)
INN KYUNG-SOO (KR)
JANG EUNGYEONG (KR)
LEE KYUNG-TAE (KR)
LEE JANG-HOON (KR)
INN KYUNG-SOO (KR)
JANG EUNGYEONG (KR)
LEE KYUNG-TAE (KR)
Application Number:
PCT/KR2017/004184
Publication Date:
October 26, 2017
Filing Date:
April 19, 2017
Export Citation:
Assignee:
UNIV-INDUSTRY COOP GROUP OF KYUNG HEE UNIV (KR)
International Classes:
A61K36/282; A23L33/105; A61K31/522; A61K31/675; A61K36/739; A61K36/9066; A61K45/06
Foreign References:
| CN1249180A | 2000-04-05 | |||
| KR20150046916A | 2015-05-04 | |||
| KR20110117540A | 2011-10-27 |
Other References:
ZHAO, Y.: "Isolation, synthesis and anti-hepatitis B virus evaluation of p-hydroxyacetophenone derivatives from Artemisia capillaris", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 25, 2015, pages 1509 - 1514, XP029148580, DOI: doi:10.1016/j.bmcl.2015.02.024
RECHTMAN, M. M.: "Curcumin inhibits hepatitis B virus via down- regulation of the metabolic coactivator PGC-1a", FEBS LETTERS, vol. 584, 2010, pages 2485 - 2490, XP027093735
RECHTMAN, M. M.: "Curcumin inhibits hepatitis B virus via down- regulation of the metabolic coactivator PGC-1a", FEBS LETTERS, vol. 584, 2010, pages 2485 - 2490, XP027093735
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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