Title:
COMPOSITION CONTAINING CELLS TREATED WITH 15-PGDH INHIBITOR OR CULTURE THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2017/074043
Kind Code:
A1
Abstract:
The present invention relates to a composition containing cells, cultured by adding 15-PGDH inhibitor to PGE2-expressing cells, or a culture thereof and a use thereof. More specifically, the present invention relates to: a pharmaceutical composition, containing cells, cultured by adding 15-PGDH inhibitor to PGE2-expressing cells, or a culture thereof, for the prevention or treatment of immunological diseases, inflammatory diseases, or wounds; a method for inhibiting an immune response, an inflammatory response, or wounds in a subject, the method comprising a step for administering the pharmaceutical composition, or the cells or the culture thereof, to the subject; a method for preparing an immunosuppressive agent, an antiinflammatory agent, or a wound healing agent, using the cells or the culture thereof; a method for preparing PGE2, the method comprising a step for adding a 15-PGDH inhibitor to PGE2-expressing cells, followed by culturing; an implant comprising PGE2-expressing cells and a 15-PGDH inhibitor; a method for preparing the implant; a complex comprising PGE2-expressing cells and a 15-PGDH inhibitor; and a culture obtained by adding a 15-PGDH inhibitor to PGE2-expressing cells.
Inventors:
HAN KYU BOEM (KR)
LEE HONG KI (KR)
LEE SEONG HUN (KR)
LEE HONG KI (KR)
LEE SEONG HUN (KR)
Application Number:
PCT/KR2016/012125
Publication Date:
May 04, 2017
Filing Date:
October 27, 2016
Export Citation:
Assignee:
EHLBIO CO LTD (KR)
HAN KYU BOEM (KR)
HAN KYU BOEM (KR)
International Classes:
A61K31/352; A61K8/34; A61K8/49; A61K31/05; A61K31/34; A61K31/415; A61Q5/00; A61Q19/00
Domestic Patent References:
| WO2010077101A2 | 2010-07-08 |
Foreign References:
| KR20120085209A | 2012-07-31 | |||
| KR20140010576A | 2014-01-27 |
Other References:
ZHANG, Y. ET AL.: "Inhibition of the Prostaglandin-Degrading Enzyme 15-PGDH Potentiates Tissue Regeneration", SCIENCE, vol. 348, no. 6240, June 2015 (2015-06-01), pages 1223, aaa2340, XP055348197
SHEIBANE, A. F. ET AL.: "Prostaglandin E2 Exacerbates Collagen-Induced Arthritis in Mice through the Inflammatory Interleukin-23/interleukin-17 Axis", ARTHRITIS & RHEUMATISM, vol. 56, no. 8, 2007, pages 2608 - 2619, XP055382251
SHEIBANE, A. F. ET AL.: "Prostaglandin E2 Exacerbates Collagen-Induced Arthritis in Mice through the Inflammatory Interleukin-23/interleukin-17 Axis", ARTHRITIS & RHEUMATISM, vol. 56, no. 8, 2007, pages 2608 - 2619, XP055382251
Attorney, Agent or Firm:
KIM, Tae Sun (KR)
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