Title:
COMPOSITION CONTAINING INHIBITORS OF THE EXPRESSION OR ACTIVITY OF SH3RF2 FOR PREVENTING OR TREATING CANCER
Document Type and Number:
WIPO Patent Application WO/2011/090283
Kind Code:
A2
Abstract:
The present invention relates to a composition containing inhibitors of the expression or activity of SH3 domain containing ring finger 2 (SH3RF2) for the preventing or treating cancer. More specifically, since the SH3RF2 protein, the expression level of which is increased in various cancer tissues, binds to PAK4, which is a cancer-associated gene, to regulate an apoptosis inhibitory function of the PAK4 protein by ubiquitination activity in the RING domain of SH3RF2, cancer cells, in which the expression of SH3RF2 is inhibited, sensitively respond to the induction of apoptosis to facilitate apoptosis and reduce in vivo tumorigenicity, such that an inhibitor of the expression or activity of SHRF2 may be useful as a composition for the prevention or treatment of cancer.
Inventors:
PARK KYUNG CHAN (KR)
YEOM YOUNG IL (KR)
KIM TAE WOO (KR)
PARK ZEE-YONG (KR)
KANG YUN KYUNG (KR)
YANG SUK-JIN (KR)
CHOI BYUNG-JUNG (KR)
LEE DONG CHUL (KR)
SHON HYUN AHM (KR)
YOO HYANG-SOOK (KR)
YEOM YOUNG IL (KR)
KIM TAE WOO (KR)
PARK ZEE-YONG (KR)
KANG YUN KYUNG (KR)
YANG SUK-JIN (KR)
CHOI BYUNG-JUNG (KR)
LEE DONG CHUL (KR)
SHON HYUN AHM (KR)
YOO HYANG-SOOK (KR)
Application Number:
PCT/KR2011/000108
Publication Date:
July 28, 2011
Filing Date:
January 07, 2011
Export Citation:
Assignee:
KOREA RES INST OF BIOSCIENCE (KR)
PARK KYUNG CHAN (KR)
YEOM YOUNG IL (KR)
KIM TAE WOO (KR)
PARK ZEE-YONG (KR)
KANG YUN KYUNG (KR)
YANG SUK-JIN (KR)
CHOI BYUNG-JUNG (KR)
LEE DONG CHUL (KR)
SHON HYUN AHM (KR)
YOO HYANG-SOOK (KR)
PARK KYUNG CHAN (KR)
YEOM YOUNG IL (KR)
KIM TAE WOO (KR)
PARK ZEE-YONG (KR)
KANG YUN KYUNG (KR)
YANG SUK-JIN (KR)
CHOI BYUNG-JUNG (KR)
LEE DONG CHUL (KR)
SHON HYUN AHM (KR)
YOO HYANG-SOOK (KR)
International Classes:
A61K31/7105; A61K31/7088; A61K39/395; A61P35/00
Domestic Patent References:
| WO2009124090A1 | 2009-10-08 |
Other References:
SHIH-CHICH CHOU ET AL.: 'Identification of genetic networks during mesenchymal stem cell transformation into neurons.' CHINESE JOURNAL OF PHYSIOLOGY vol. 51, no. 4, 2008, pages 230 - 246
MIEKO NISHIU ET AL.: 'Distinct pattern of gene expression in pyothorax-associated lymphoma (PAL), a lymphoma developing in long-standing inflammation.' CANCER SCI. vol. 95, 2004, pages 828 - 834
LYNN M. KNOWLES ET AL.: 'Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.' BMC GENOMICS vol. 8, 2007, page 168
MIEKO NISHIU ET AL.: 'Distinct pattern of gene expression in pyothorax-associated lymphoma (PAL), a lymphoma developing in long-standing inflammation.' CANCER SCI. vol. 95, 2004, pages 828 - 834
LYNN M. KNOWLES ET AL.: 'Genome-wide changes accompanying knockdown of fatty acid synthase in breast cancer.' BMC GENOMICS vol. 8, 2007, page 168
Attorney, Agent or Firm:
LEE, WON-HEE (KR)
이원희 (KR)
이원희 (KR)
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Claims: