Title:
COMPOSITION FOR CULTURING REGULATORY T CELLS AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2021/101273
Kind Code:
A2
Abstract:
The present invention relates to a method for effectively proliferating regulatory T cells, by which, particularly, in the presence of a fusion protein dimer comprising IL-2 protein or a variant thereof and CD80 protein or a fragment thereof, CD4+, CD25+, and CD127- T cells can be effectively proliferated. In particular, when combined with a predetermined cell culture medium, regulatory T cells such as CD4+, CD25+, and CD127- can be effectively and specifically proliferated. In addition, when the method is used, it has been confirmed that the survival rate of regulatory T cells is remarkably increased as compared to a conventionally used culture method using IL-2, and a significant increase in the yield of Foxp3+ regulatory T cells has been confirmed. Thus, such a proliferation method can be used in the field of cell therapeutic agents using regulatory T cells.
Inventors:
JANG MYUNG HO (KR)
HONG CHUN-PYO (KR)
KIM CHEA HA (KR)
KIM HYE RI (KR)
HONG CHUN-PYO (KR)
KIM CHEA HA (KR)
KIM HYE RI (KR)
Application Number:
PCT/KR2020/016382
Publication Date:
May 27, 2021
Filing Date:
November 19, 2020
Export Citation:
Assignee:
GI CELL INC (KR)
International Classes:
C12N5/0783; A61K35/17; A61P19/02; A61P29/00
Foreign References:
| US5229109A | 1993-07-20 | |||
| KR101667096B1 | 2016-10-18 |
Other References:
R K GERSHONK KONDO, IMMUNOLOGY, vol. 18, 1970, pages 723 - 37
S SAKAGUCHI, J IMMUNOL, vol. 155, 1995, pages 1151 - 1164
H NISHIKAWA, INT. J. CANCER, vol. 127, 2010, pages 759 - 767
S. KARUMUTHIL-MELETHIL, DIABETES, vol. 64, 2015, pages 1341 - 1357
See also references of EP 4063490A4
S SAKAGUCHI, J IMMUNOL, vol. 155, 1995, pages 1151 - 1164
H NISHIKAWA, INT. J. CANCER, vol. 127, 2010, pages 759 - 767
S. KARUMUTHIL-MELETHIL, DIABETES, vol. 64, 2015, pages 1341 - 1357
See also references of EP 4063490A4
Attorney, Agent or Firm:
RYU, Jong Woo et al. (KR)
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