Title:
COMPOSITION FOR DETECTING BLADDER CANCER, KIT, AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2024/066941
Kind Code:
A1
Abstract:
Provided is a composition for detecting bladder cancer. The composition comprises a detection reagent for detecting at least one of the following methylation sites: cg00206063, cg03278514, and cg13314394. Also provided are use of the composition, and a kit comprising the composition. In a tissue sample, all compositions can predict bladder cancer with a specificity of at least 0.8571, a sensitivity of 0.7203, and an area under the curve of 0.8585. However, in a urine free DNA sample, all the compositions can predict the bladder cancer with a specificity of at least 0.9048, a sensitivity of 0.6525, and an area under the curve of 0.8060. The composition can detect the bladder cancer clinically with a high sensitivity and a good specificity using fewer markers, such that both the cost and time are saved. Clinically, bladder cancer malignant transformation can be sensitively and specifically detected at an early stage.
Inventors:
DAI LIZHONG (CN)
YANG LI (CN)
PENG LEI (CN)
LIU JIA (CN)
HONG MEI (CN)
HU ZHIHONG (CN)
CHEN MING (CN)
YANG LI (CN)
PENG LEI (CN)
LIU JIA (CN)
HONG MEI (CN)
HU ZHIHONG (CN)
CHEN MING (CN)
Application Number:
PCT/CN2023/116826
Publication Date:
April 04, 2024
Filing Date:
September 04, 2023
Export Citation:
Assignee:
SANSURE BIOTECH INC (CN)
International Classes:
C12Q1/6886; C07K14/47; C12N15/11; C12N15/12
Attorney, Agent or Firm:
CHINA PAT INTELLECTUAL PROPERTY OFFICE (CN)
Download PDF:
Previous Patent: SOLAR CELL WITH SPONTANEOUS POLARIZATION STRUCTURE
Next Patent: INFORMATION TRANSMISSION METHOD AND APPARATUS
Next Patent: INFORMATION TRANSMISSION METHOD AND APPARATUS