Title:
COMPOSITION FOR DETECTING OR ISOLATING NUCLEIC ACIDS AND METHOD FOR DETECTING OR ISOLATING NUCLEIC ACIDS USING SAME
Document Type and Number:
WIPO Patent Application WO/2023/211130
Kind Code:
A1
Abstract:
One aspect of the present invention relates to a composition and a kit for detecting or isolating nucleic acids, and a method for detecting or isolating nucleic acids using same. Using the composition, kit, and method for detecting or isolating nucleic acids according to one aspect of the present invention can rapidly, simply, and accurately detect or isolate nucleic acids with high concentration and high purity at low costs without electricity and special equipment, for example, centrifugation equipment, a vacuum pump, and a heat-regulator, used in conventional column and bead-based methods. Further, the composition according to one aspect of the present invention is used to detect or isolate at least one nucleic acid selected from the group consisting of miR-141-3p, miR-375-3P, miR-483-5P and miR-574-3P in the nucleic acids, thereby enabling the rapid, accurate, and early diagnosis of prostate cancer (PCa) in a benign prostatic hyperplasia (BPH) patient, and is used to detect or isolate microorganism-derived nucleic acids causing infectious diseases, thereby enabling the rapid, accurate, and early diagnosis of infectious diseases.
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Inventors:
SHIN YONG (KR)
KOO BONHAN (KR)
KOO BONHAN (KR)
Application Number:
PCT/KR2023/005646
Publication Date:
November 02, 2023
Filing Date:
April 26, 2023
Export Citation:
Assignee:
UIF UNIV INDUSTRY FOUNDATION YONSEI UNIV (KR)
International Classes:
C12Q1/6834; C12Q1/6883; C12Q1/6886
Foreign References:
| US20110196146A1 | 2011-08-11 | |||
| KR102136695B1 | 2020-07-22 | |||
| KR20190119495A | 2019-10-22 |
Other References:
P F RUHN, S GARVER, D S HAGE: "Development of dihydrazide-activated silica supports for high-performance affinity chromatography", JOURNAL OF CHROMATOGRAPHY. A, ELSEVIER B.V, NETHERLANDS, 27 May 1994 (1994-05-27), pages 9 - 19, XP055114373, DOI: 10.1016/0021-9673(94)80332-3
ABRAMOVIC IRENA, VRHOVEC BORNA, SKARA LUCIJA, VRTARIC ALEN, NIKOLAC GABAJ NORA, KULIS TOMISLAV, STIMAC GORAN, LJILJAK DEJAN, RUZIC: "MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia", CANCERS, vol. 13, no. 9, pages 2068, XP093105139, DOI: 10.3390/cancers13092068
KOO BONHAN, KIM YUNLIM, JANG YOON OK, LIU HUIFANG, KIM MYOUNG GYU, LEE HYO JOO, WOO MYUNG KYUN, KIM CHOUNGâSOO, SHIN YONG: "A novel platform using homobifunctional hydrazide for enrichment and isolation of urinary circulating RNAs", BIOENGINEERING & TRANSLATIONAL MEDICINE, vol. 8, no. 1, 1 January 2023 (2023-01-01), XP093105151, ISSN: 2380-6761, DOI: 10.1002/btm2.10348
ABRAMOVIC IRENA, VRHOVEC BORNA, SKARA LUCIJA, VRTARIC ALEN, NIKOLAC GABAJ NORA, KULIS TOMISLAV, STIMAC GORAN, LJILJAK DEJAN, RUZIC: "MiR-182-5p and miR-375-3p Have Higher Performance Than PSA in Discriminating Prostate Cancer from Benign Prostate Hyperplasia", CANCERS, vol. 13, no. 9, pages 2068, XP093105139, DOI: 10.3390/cancers13092068
KOO BONHAN, KIM YUNLIM, JANG YOON OK, LIU HUIFANG, KIM MYOUNG GYU, LEE HYO JOO, WOO MYUNG KYUN, KIM CHOUNGâSOO, SHIN YONG: "A novel platform using homobifunctional hydrazide for enrichment and isolation of urinary circulating RNAs", BIOENGINEERING & TRANSLATIONAL MEDICINE, vol. 8, no. 1, 1 January 2023 (2023-01-01), XP093105151, ISSN: 2380-6761, DOI: 10.1002/btm2.10348
Attorney, Agent or Firm:
ISIS IP LAW LLC (KR)
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