Title:
COMPOSITION FOR DIAGNOSING RECURRING GLIOBLASTOMA MULTIFORME AND METHOD FOR DIAGNOSING SAME
Document Type and Number:
WIPO Patent Application WO/2014/014322
Kind Code:
A1
Abstract:
The present invention relates to a recurring glioblastoma multiforme marker miRAN for diagnosing recurring glioblastoma multiforme, and more specifically, to a composition for sorting the miRNA marker, which is specific to the recurring glioblastoma multiforme and comprises an agent for detecting the presence of the marker, a kit, and to a method for diagnosing the recurring glioblastoma multiforme using same. The method for diagnosing the recurring glioblastoma multiforme by using the recurring glioblastoma multiforme marker miRNA, according to the present invention, provides diagnosis markers, which can diagnose the occurrence of the recurring glioblastoma multiforme, thereby providing useful material for managing treatment and prognosis of the recurring glioblastoma multiforme. In addition, the diagnosis markers for the recurring glioblastoma multiforme can be used for development and research of an anticancer agent specific to the recurring glioblastoma multiforme.
Inventors:
KIM GUN-HWA (KR)
KIM GIWON (KR)
KIM SOOHYUN (KR)
KIM SEUNG IL (KR)
PARK EDMOND CHANGKYUN (KR)
KIM GIWON (KR)
KIM SOOHYUN (KR)
KIM SEUNG IL (KR)
PARK EDMOND CHANGKYUN (KR)
Application Number:
PCT/KR2013/006519
Publication Date:
January 23, 2014
Filing Date:
July 22, 2013
Export Citation:
Assignee:
KOREA BASIC SCIENCE INST (KR)
International Classes:
C12N15/113; C12Q1/68
Foreign References:
| US20110301221A1 | 2011-12-08 |
Other References:
MALZKORN, B. ET AL.: "Identification and functional characterization of microRNAs involved in the malignant progression of gliomas", BRAIN PATHOLOGY, vol. 20, May 2010 (2010-05-01), pages 539 - 550
MATHUPALA, S. P. ET AL.: "MicroRNA and brain tumors: A cause and a cure?", DNA AND CELL BIOLOGY, vol. 26, no. 5, May 2007 (2007-05-01), pages 301 - 310
NIYAZI, M. ET AL.: "miRNA expression patterns predict survival in glioblastoma", RADIATION ONCOLOGY, vol. 6, no. 153, 10 November 2011 (2011-11-10)
MATHUPALA, S. P. ET AL.: "MicroRNA and brain tumors: A cause and a cure?", DNA AND CELL BIOLOGY, vol. 26, no. 5, May 2007 (2007-05-01), pages 301 - 310
NIYAZI, M. ET AL.: "miRNA expression patterns predict survival in glioblastoma", RADIATION ONCOLOGY, vol. 6, no. 153, 10 November 2011 (2011-11-10)
Attorney, Agent or Firm:
LEE, Hee Sook et al. (9th Fl JS Building,Teheran-ro 33 gil 11,Yeoksam-dong, Gangnam-gu, Seoul 135-915, KR)
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