Title:
COMPOSITION FOR DIAGNOSING SEPTICEMIA USING TGFBI, PHARMACEUTICAL COMPOSITION FOR PREVENTING AND TREATING SEPTICEMIA USING SAME, AND SCREENING METHOD THEREFOR
Document Type and Number:
WIPO Patent Application WO/2014/185631
Kind Code:
A1
Abstract:
The present invention relates to a composition for diagnosing septicemia using TGFBI, a pharmaceutical composition for preventing or treating septicemia using the same, and a screening method therefor and, more specifically, to a composition screening method for preventing and treating septicemia using a TGFBI protein expression level measurement, a composition for treating septicemia including a TGFBI inhibitor, a composition for diagnosing septicemia including a TGFBI protein expression level measurement medicine, a diagnostic kit, and a diagnostic method or the like. A TGFBIp tremendously increases when septicemia occurs, and if the expression of the TGFBIp is reduced, a fatality rate, which is caused by the septicemia, and the permeability of vascular endothelial cells can be decreased. Thus, it is possible to select an anti-septic agent by using the TGFBIp and to prepare a pharmaceutical composition for preventing or treating septicemia by using a TGFBIp inhibitor, and septicemia can be effectively diagnosed by measuring the expression levels of TGFBI proteins.
Inventors:
BAE JONG-SUP (KR)
KIM IN-SAN (KR)
LEE WONHWA (KR)
KIM SHIN-WOO (KR)
KIM IN-SAN (KR)
LEE WONHWA (KR)
KIM SHIN-WOO (KR)
Application Number:
PCT/KR2014/003069
Publication Date:
November 20, 2014
Filing Date:
April 09, 2014
Export Citation:
Assignee:
KYUNGPOOK NAT UNIV IND ACAD (KR)
International Classes:
G01N33/68; C12N15/11; C12Q1/68
Foreign References:
| KR20110127637A | 2011-11-25 | |||
| US20110105350A1 | 2011-05-05 | |||
| US20110217301A1 | 2011-09-08 | |||
| US20080286763A1 | 2008-11-20 |
Other References:
DATABASE NCBL 14 December 2004 (2004-12-14), accession no. C132886.18
DATABASE NCBI 2 January 2007 (2007-01-02), accession no. C129900.1
DATABASE NCBI 2 January 2007 (2007-01-02), accession no. C129900.1
Attorney, Agent or Firm:
LEE, Hee Sook et al. (9th Fl. Teheran-ro 33 gil 11, Gangnam-gu Seoul 135-915, KR)
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