Title:
COMPOSITION FOR DIAGNOSING SJÖGREN'S SYNDROME
Document Type and Number:
WIPO Patent Application WO/2018/164385
Kind Code:
A1
Abstract:
Provided in the present invention are a diagnostic composition for differentiating dry eye from dry eye caused by Sjögren's syndrome by using ATG5 and LC3B-II as biomarkers, a diagnostic method, and a screening method thereof. It is ascertained that when ATG5 and LC3B-II are used as biomarkers, only Sjögren's syndrome, excluding non-Sjögren's syndrome, can be effectively differentiated from dry eye, and thus the present invention can be usable in related industries.
Inventors:
CHUNG SO-HYANG (KR)
LEE HYUN-JUNG (KR)
LEE HYUN-JUNG (KR)
Application Number:
PCT/KR2018/001815
Publication Date:
September 13, 2018
Filing Date:
February 12, 2018
Export Citation:
Assignee:
CATHOLIC UNIV KOREA IND ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
C12Q1/6883; G01N33/68
Foreign References:
| US20140314715A1 | 2014-10-23 | |||
| US20150273083A1 | 2015-10-01 | |||
| US20160024580A1 | 2016-01-28 |
Other References:
SEO, YU RI ET AL.: "Transmission Electron Microscopic Findings of Lacrimal Gland Acinar Cells Induced by in Vivo Dry Eye", JOURNAL OF THE KOREAN OPTHALMOLOGICAL SOCIETY, vol. 55, no. 8, 2014, pages 1187 - 1194
CHINSKEY, NICHOLAS D.: "Control of photoreceptor autophagy after retinal detachment: the switch from survival to death", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 55, no. 2, 2014, pages 688 - 695, XP055506369
BYUN, YONG-SOO: "Elevation of autophagy markers in Sjgren syndrome dry eye", SCIENTIFIC REPORTS, vol. 1, no. 17280, 7 December 2017 (2017-12-07), pages 1 - 11, XP055605971
CHINSKEY, NICHOLAS D.: "Control of photoreceptor autophagy after retinal detachment: the switch from survival to death", INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, vol. 55, no. 2, 2014, pages 688 - 695, XP055506369
BYUN, YONG-SOO: "Elevation of autophagy markers in Sjgren syndrome dry eye", SCIENTIFIC REPORTS, vol. 1, no. 17280, 7 December 2017 (2017-12-07), pages 1 - 11, XP055605971
Attorney, Agent or Firm:
WIE, Byoung-Gap (KR)
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