Title:
COMPOSITION FOR ENHANCEMENT OF IMMUNE ACTIVITY CONTAINING GENIPIN OR DERIVATIVE THEREOF AND USE THEREOF
Document Type and Number:
WIPO Patent Application WO/2016/159435
Kind Code:
A1
Abstract:
The present invention relates to a composition for enhancement of immune activity containing genipin or a derivative thereof and to a use thereof and, more specifically, provides a pharmaceutical composition or food composition for enhancement of immune activity containing genipin or a derivative thereof. The genipin or derivative thereof according to the present invention exhibits effects, such as increasing the number of CD4+ T cells and CD8+ T cells and decreasing the number of regulatory T cells (Treg). In addition, the genipin or derivative thereof is a natural material, and thus can also reduce side effects that frequently occur from chemical materials. Therefore, it is expected that the genipin or derivative thereof can be favorably used as an active ingredient of a pharmaceutical composition or food composition for enhancement of immune activity.
Inventors:
LEE SUN MEE (KR)
KIM SO-JIN (KR)
KIM JOON-SUNG (KR)
KIM SO-JIN (KR)
KIM JOON-SUNG (KR)
Application Number:
PCT/KR2015/004131
Publication Date:
October 06, 2016
Filing Date:
April 24, 2015
Export Citation:
Assignee:
UNIV SUNGKYUNKWAN RES & BUS (KR)
International Classes:
A61K31/35; A61K9/16; A61K9/20
Other References:
NAM, K. N . ET AL.: "Genipin Inhibits the Inflammatory Response of Rat Brain Microglial Cells", INTERNATIONAL IMMUNOPHARMACOLOGY, vol. 10, 2010, pages 493 - 499, XP026980501
KIM, T.-H. ET AL.: "Genipin Attenuates Sepsis by Inhibiting Toll-like Receptor Signaling", MOLECULAR MEDICINE, vol. 18, no. 3, 2012, pages 455 - 465, XP055316294
KOO, H. -J. ET AL.: "Antiinflammatory Effects of Genipin, an Active Principle of Gardenia", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 495, no. 2-3, 2004, pages 201 - 208, XP055316488
SHINDO, S. ET AL.: "Genipin Inhibits IL -1beta-induced CCL20 and IL -6 Production from Human Periodontal Ligament Cells", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 33, no. 2, 2014, pages 357 - 364, XP055316490
ZHANG, C. -Y. ET AL.: "Genipin Inhibits UCP2-Mediated Proton Leak and Acutely Reverses Obesity- and High Glucose-Induced beta Cell Dysfunction in Isolated Pancreatic Islets", CELL METABOLISM, vol. 3, no. 6, 2006, pages 417 - 427, XP055316493
CHOI, H. -S. ET AL.: "Genipin Attenuates Immunosuppression through Inhibition of Regulatory T Cell Expansion and Cytotoxic T-lymphocyte Antigen-4 Expression in Late Phase of Sepsis", THE KOREAN SOCIETY OF APPLIED PHARMACOLOGY, 2014 PROCEEDING OF AUTUMN CONFERENCE, vol. 27, no. 1, 31 October 2014 (2014-10-31), pages 15 - 23, XP029187811
KIM, T.-H. ET AL.: "Genipin Attenuates Sepsis by Inhibiting Toll-like Receptor Signaling", MOLECULAR MEDICINE, vol. 18, no. 3, 2012, pages 455 - 465, XP055316294
KOO, H. -J. ET AL.: "Antiinflammatory Effects of Genipin, an Active Principle of Gardenia", EUROPEAN JOURNAL OF PHARMACOLOGY, vol. 495, no. 2-3, 2004, pages 201 - 208, XP055316488
SHINDO, S. ET AL.: "Genipin Inhibits IL -1beta-induced CCL20 and IL -6 Production from Human Periodontal Ligament Cells", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 33, no. 2, 2014, pages 357 - 364, XP055316490
ZHANG, C. -Y. ET AL.: "Genipin Inhibits UCP2-Mediated Proton Leak and Acutely Reverses Obesity- and High Glucose-Induced beta Cell Dysfunction in Isolated Pancreatic Islets", CELL METABOLISM, vol. 3, no. 6, 2006, pages 417 - 427, XP055316493
CHOI, H. -S. ET AL.: "Genipin Attenuates Immunosuppression through Inhibition of Regulatory T Cell Expansion and Cytotoxic T-lymphocyte Antigen-4 Expression in Late Phase of Sepsis", THE KOREAN SOCIETY OF APPLIED PHARMACOLOGY, 2014 PROCEEDING OF AUTUMN CONFERENCE, vol. 27, no. 1, 31 October 2014 (2014-10-31), pages 15 - 23, XP029187811
Attorney, Agent or Firm:
LEE, MYOUNG-JIN (KR)
이명진 (KR)
이명진 (KR)
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