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Patent Searching and Data


Title:
COMPOSITION FOR ENHANCING CELL ENGRAFTMENT AND HOMING PROPERTIES, CONTAINING PRP AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2013/180431
Kind Code:
A1
Abstract:
The present invention provides a composition for enhancing cell engraftment and homing properties, containing platelet-rich plasma (PRP) as an active ingredient. The present invention provides a method for improving cell engraftment and homing properties, comprising the step of treating in vitro isolated cells with a composition containing PRP as an active ingredient. According to the present invention, when a cell to be transplanted or a region to which cells are transplanted is treated with PRP, or a cell to be transplanted is mixed with PRP, transplantation to an in vivo region is carried out, thereby increasing cell engraftment in a transplanted region and increasing cell homing from a transplanted region to a damaged region.

Inventors:
JO HYUN CHUL (KR)
KIM HYANG (KR)
Application Number:
PCT/KR2013/004642
Publication Date:
December 05, 2013
Filing Date:
May 28, 2013
Export Citation:
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Assignee:
SNU R&DB FOUNDATION (KR)
International Classes:
C12N5/078; A61L27/38; C12N5/074
Foreign References:
KR101038616B12011-06-03
Other References:
LANGER, H. ET AL.: "Adherent platelets recruit and induce differentiation of murine embryonic endothelial progenitor cells to mature endothelial cells in vitro.", CIRCULATION RESEARCH., vol. 98, no. 2, 3 February 2006 (2006-02-03), pages E2 - 10
MEHTA, V.: "Platelet-rich plasma: a review of the science and possible clinical applications.", ORTHOPEDICS., vol. 33, no. 2, February 2010 (2010-02-01), pages 111 - 114
ROOKMAAKER, M. B. ET AL.: "Met-RANTES reduces endothelial progenitor cell homing to activated (glomerular) endothelium in vitro and in vivo.", AMERICAN JOURNAL OF PHYSIOLOGY-RENAL PHYSIOLOGY, vol. 293, no. 2, August 2007 (2007-08-01), pages F624 - 30
MARX, R. E.: "Platelet-rich plasma (PRP): what is PRP and what is not PRP?", IMPLANT DENTISTRY., vol. 10, no. 4, 2001, pages 225 - 8
Attorney, Agent or Firm:
PARK, Weonmee (412 Nonhyeon-roGangnam-gu, Seoul 138-715, KR)
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