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Title:
COMPOSITION FOR EXTERNAL APPLICATION TO SKIN CONTAINING NOVEL BENZYLIDENE AZOLIDINE DERIVATIVE OR SALT THEREOF
Document Type and Number:
WIPO Patent Application WO/2015/046390
Kind Code:
A1
Abstract:
The present invention relates to providing a composition for external application to the skin, wherein a benzylidene azolidine derivative or a salt thereof has improved dissolution stability, said benzylidene azolidine derivative being a novel neutral compound that is hydrophilic and safe to the skin, while having an ultraviolet absorbing effect (especially an UVA absorbing effect). A composition for external application to the skin, which is characterized by containing a benzylidene azolidine derivative represented by general formula (I) or a salt thereof and at least one substance selected from the group consisting of organic acids, hydroxyalkyl ureas, polyhydric alcohols, alkyl ethers thereof, and hydroxyalkyl amines. (In structural formula (I), n represents an integer of 1-5; A1 represents O, S or N-A4; and each of A2, A3 and A4 independently represents a hydrogen atom, a C1-C8 alkyl group which may be substituted by a hydroxyl group, or the like (provided that one or more hydroxyl groups are contained in at least one of A2, A3 and A4).)

Inventors:
KOBAYASHI YOSUKE (JP)
MIZUTARE YOKO (JP)
MAEZAWA YASUHISA (JP)
SHIMIZU TAKASHI (JP)
FUKUSHIMA KAZUHIRO (JP)
Application Number:
PCT/JP2014/075546
Publication Date:
April 02, 2015
Filing Date:
September 26, 2014
Export Citation:
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Assignee:
ROHTO PHARMA (JP)
International Classes:
A61K8/49; A61K8/02; A61K8/33; A61K8/34; A61K8/41; A61K8/42; A61Q17/04
Domestic Patent References:
WO2013146932A12013-10-03
Foreign References:
JP2011526616A2011-10-13
JPH08127589A1996-05-21
JPH09241289A1997-09-16
JPH0789838A1995-04-04
JPH11116457A1999-04-27
JPH0770084A1995-03-14
JPH02111760A1990-04-24
JPH05345713A1993-12-27
Other References:
POPOV-PERGAL, KATARINA ET AL.: "Synthesis of 2-(5-arylidene-2,4-dioxotetrahydro-1,3- thiazolyl-3)-ethanols", J. SERB. CHEM. SOC., vol. 60, no. 9, 1995, pages 745 - 748
Attorney, Agent or Firm:
UNIUS PATENT ATTORNEYS OFFICE (JP)
Patent business corporation ユニアス international patent firm (JP)
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