Title:
COMPOSITION FOR GENE DELIVERY COMPRISING CHITOSAN AND LIQUID CRYSTAL FORMATION MATERIAL
Document Type and Number:
WIPO Patent Application WO/2014/133351
Kind Code:
A1
Abstract:
Disclosed herein is a composition for gene delivery which forms into liquid crystals in an aqueous fluid including chitosan and a liquid crystal formation material. The composition of the present invention including chitosan and a liquid crystal formation material improves the relatively low binding strength between chitosan and a gene, and also considerably increases the stability of a chitosan nanocomposite in blood serum, thereby performing highly efficient gene delivery and providing excellent stability, thus being useful as a gene therapeutic agent.
Inventors:
HWANG HO YOUNG (KR)
HWANG JI HYEH (KR)
LEE YOUNG NAM (KR)
NOH SANG MYOUNG (KR)
KI MIN HYO (KR)
HWANG JI HYEH (KR)
LEE YOUNG NAM (KR)
NOH SANG MYOUNG (KR)
KI MIN HYO (KR)
Application Number:
PCT/KR2014/001656
Publication Date:
September 04, 2014
Filing Date:
February 28, 2014
Export Citation:
Assignee:
CHONG KUN DANG PHARM CORP (KR)
International Classes:
A61K31/722; A61K47/30; A61K48/00
Other References:
LIU, W. G. ET AL.: "N-alkylated chitosan as a potential nonviral vector for gene transfection", BIOCONJUGATE CHEMISTRY, vol. 14, 2003, pages 782 - 789, XP055274733
SAFINYA, C. R. ET AL.: "Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications", PHILOSOPHICAL TRANSACTIONS O THE ROYAL SOCIETY A: MATHEMATICAL, PHYSICAL AND ENGINEERING SCIENCES, vol. 364, 2006, pages 2573 - 2596, XP055274750
MANSOURI, S. ET AL.: "Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 57, 2004, pages 1 - 8, XP004518747
SAMINATHAN, M. ET AL.: "Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics", NUCLEIC ACIDS RESEARCH, vol. 30, no. 17, 2002, pages 3722 - 3731, XP002700434
UNGAR, G. ET AL.: "Giant supramolecular liquid crystal lattice", SCIENCE, vol. 299, no. 5610, 2003, pages 1208 - 1211, XP055274763
See also references of EP 2961414A4
SAFINYA, C. R. ET AL.: "Cationic liposome-DNA complexes: from liquid crystal science to gene delivery applications", PHILOSOPHICAL TRANSACTIONS O THE ROYAL SOCIETY A: MATHEMATICAL, PHYSICAL AND ENGINEERING SCIENCES, vol. 364, 2006, pages 2573 - 2596, XP055274750
MANSOURI, S. ET AL.: "Chitosan-DNA nanoparticles as non-viral vectors in gene therapy: strategies to improve transfection efficacy", EUROPEAN JOURNAL OF PHARMACEUTICS AND BIOPHARMACEUTICS, vol. 57, 2004, pages 1 - 8, XP004518747
SAMINATHAN, M. ET AL.: "Polyamine structural effects on the induction and stabilization of liquid crystalline DNA: potential applications to DNA packaging, gene therapy and polyamine therapeutics", NUCLEIC ACIDS RESEARCH, vol. 30, no. 17, 2002, pages 3722 - 3731, XP002700434
UNGAR, G. ET AL.: "Giant supramolecular liquid crystal lattice", SCIENCE, vol. 299, no. 5610, 2003, pages 1208 - 1211, XP055274763
See also references of EP 2961414A4
Attorney, Agent or Firm:
AHN, So-Young (4th Fl. 344, Seocho-daero,Seocho-gu, Seoul 137-881, KR)
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