Title:
COMPOSITION HAVING ANTIFUNGAL ACTIVITY
Document Type and Number:
WIPO Patent Application WO/2017/038872
Kind Code:
A1
Abstract:
The present invention provides a novel composition having an antifungal activity without depending on conventional compositions having anticandidal activity or combinations of such compositions. More specifically, the composition according to the present invention having an antifungal activity comprises a complex of lysozyme bonded to chitosan. The composition according to the present invention is applicable to candidiasis of the skin and mucous membranes, in particular, oral candidiasis and vagina candidiasis affecting a large number of patients and can ameliorate the symptoms of these diseases, heal the same and prevent infection of the same. The composition comprises a complex of lysozyme, which has been widely used as a highly safe natural food additive, with a polysaccharide and, therefore, can reassure patients who use the same and ease their burden. The composition according to the present invention comprises a complex of lysozyme, which is a highly safe natural food additive, with a polysaccharide and, therefore, can be safely used by patients without considering any risk.
Inventors:
KAGESHIMA HIROKI (JP)
SAITO AKIRA (JP)
MURAKAMI YOICHI (JP)
ABE SHIGERU (JP)
HAYAMA KAZUMI (JP)
TAKAHASHI MIKI (JP)
ABE MIHO (JP)
SAITO AKIRA (JP)
MURAKAMI YOICHI (JP)
ABE SHIGERU (JP)
HAYAMA KAZUMI (JP)
TAKAHASHI MIKI (JP)
ABE MIHO (JP)
Application Number:
PCT/JP2016/075499
Publication Date:
March 09, 2017
Filing Date:
August 31, 2016
Export Citation:
Assignee:
WAKO FILTER TECH CO LTD (JP)
UNIV TEIKYO (JP)
UNIV TEIKYO (JP)
International Classes:
A61K38/46; A61K31/045; A61K31/122; A61K31/19; A61K31/722; A61P31/10; A61P43/00
Foreign References:
| JP2003089652A | 2003-03-28 |
Other References:
SONG, YOUTAO ET AL.: "Emulsifying properties and bactericidal action of chitosan.lysozyme conjugates", FOOD RESEARCH INTERNATIONAL, vol. 35, 2002, pages 459 - 466, XP002666465
"WAFTEC Bio & Healthcare Jigyo Suishin Honbu no Shokai Shiryo", 28 August 2015 (2015-08-28), pages 3, Retrieved from the Internet [retrieved on 20160929]
WANG, LI-DAN ET AL.: "Bactericidal properties of chitosan and lysozyme composite system", JOURNAL OF EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ( NATURAL SCIENCE EDITION, vol. 39, no. 3, 2013, pages 284 - 288, ISSN: 1006-3080
BERGSSON, GUDMUNDUR ET AL.: "In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides", ANTIMICROBAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 11, 2001, pages 3209 - 12, XP003000265, ISSN: 0066-4804
"WAFTEC Bio & Healthcare Jigyo Suishin Honbu no Shokai Shiryo", 28 August 2015 (2015-08-28), pages 3, Retrieved from the Internet
WANG, LI-DAN ET AL.: "Bactericidal properties of chitosan and lysozyme composite system", JOURNAL OF EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY ( NATURAL SCIENCE EDITION, vol. 39, no. 3, 2013, pages 284 - 288, ISSN: 1006-3080
BERGSSON, GUDMUNDUR ET AL.: "In Vitro Killing of Candida albicans by Fatty Acids and Monoglycerides", ANTIMICROBAL AGENTS AND CHEMOTHERAPY, vol. 45, no. 11, 2001, pages 3209 - 12, XP003000265, ISSN: 0066-4804
Attorney, Agent or Firm:
NISHIMURA, Ryuhei (JP)
Download PDF: