Title:
COMPOSITION HAVING ANTITUMOR EFFECT
Document Type and Number:
WIPO Patent Application WO/2005/094878
Kind Code:
A1
Abstract:
It is intended to provide a medicinal composition for transferring a chemotherapeutic agent (preferably an anticancer agent) into a cell or a living body by using a virus envelope vector. For achieving this purpose, a medicinal composition characterized by containing, as the active ingredient, a chemotherapeutic agent encapsulated in and/or combined with a virus envelope vector capable of inducing immunity is provided. Thus, an anticancer agent, which has been encapsulated into a virus envelope vector, can be introduced directly into a tumor. By using together with another anticancer agent, it is possible to induce antitumor immunity specific to tumor cells caused by HVJ-E adjuvant, thereby reducing the tumor. Moreover, a medicinal composition characterized by containing, as the active ingredients, a virus envelope vector and a chemotherapeutic agent is provided.
Inventors:
KOTANI HITOSHI (JP)
KANEDA YASUSHI (JP)
KAWANO HIROKAZU (JP)
FUKUMURA MASAYUKI (JP)
KUROOKA MASAYUKI (JP)
KANEDA YASUSHI (JP)
KAWANO HIROKAZU (JP)
FUKUMURA MASAYUKI (JP)
KUROOKA MASAYUKI (JP)
Application Number:
PCT/JP2005/006820
Publication Date:
October 13, 2005
Filing Date:
March 31, 2005
Export Citation:
Assignee:
GENOMIDEA INC (JP)
ANGESMG INC (JP)
KOTANI HITOSHI (JP)
KANEDA YASUSHI (JP)
KAWANO HIROKAZU (JP)
FUKUMURA MASAYUKI (JP)
KUROOKA MASAYUKI (JP)
ANGESMG INC (JP)
KOTANI HITOSHI (JP)
KANEDA YASUSHI (JP)
KAWANO HIROKAZU (JP)
FUKUMURA MASAYUKI (JP)
KUROOKA MASAYUKI (JP)
International Classes:
A61K9/50; A61K31/24; A61K31/282; A61K31/704; A61K31/7064; A61K33/24; A61K35/76; A61K38/00; A61K39/00; A61K39/39; A61K45/00; A61K47/18; A61K47/28; A61P35/00; A61P37/04; C07D239/54; C07D239/553; C07D487/14; C07D491/22; C07H15/12; C07H15/252; (IPC1-7): A61K39/39; A61K31/24; A61K31/282; A61K31/704; A61K31/7064; A61K35/76; A61K38/00; A61K45/00; A61K47/18; A61K47/28; A61P35/00; C07D239/553; C07D487/14; C07D491/22; C07H15/12; C07H15/252
Domestic Patent References:
| WO2003014338A1 | 2003-02-20 | |||
| WO2003029475A1 | 2003-04-10 |
Foreign References:
| JP2002508748A | 2002-03-19 | |||
| JP2001302541A | 2001-10-31 | |||
| JP2002065278A | 2002-03-05 | |||
| JP2001286282A | 2001-10-16 | |||
| JPH08508641A | 1996-09-17 |
Other References:
NAKANISHI T. ET AL: "Vaccine no Kaihatsu ni mukete no DDS", DRUG DELIVERY SYSTEM, vol. 14, no. 6, 1999, pages 459 - 469, XP002992651
PALMER J.C. ET AL: "Non.infectious virus induces cytotoxic Tlymphocytes and binds to target cells to permit their lysis", NATURE, vol. 269, 1977, pages 595 - 597, XP002992652
FUKAMI Y. ET AL: "Difference in Capacity of Sendai Virus Envelope Components to Induce Cytotoxic T Lymphocytes in Primary and Secondary Immune Responses", INFECTION AND IMMUNITY, vol. 26, no. 3, 1979, pages 815 - 821, XP002992653
TANAKA C. ET AL: "NEW Yakurigaku", 1996, pages: 557 - 568, XP002992654
PALMER J.C. ET AL: "Non.infectious virus induces cytotoxic Tlymphocytes and binds to target cells to permit their lysis", NATURE, vol. 269, 1977, pages 595 - 597, XP002992652
FUKAMI Y. ET AL: "Difference in Capacity of Sendai Virus Envelope Components to Induce Cytotoxic T Lymphocytes in Primary and Secondary Immune Responses", INFECTION AND IMMUNITY, vol. 26, no. 3, 1979, pages 815 - 821, XP002992653
TANAKA C. ET AL: "NEW Yakurigaku", 1996, pages: 557 - 568, XP002992654
Attorney, Agent or Firm:
Takashima, Hajime (Osaka Midosuji Bldg. 1-1, Fushimimachi
4-chome, Chuo-ku, Osaka-sh, Osaka 44, JP)
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