Title:
COMPOSITION HAVING IMPROVED WATER SOLUBILITY AND BIOAVAILABILITY
Document Type and Number:
WIPO Patent Application WO/2018/203636
Kind Code:
A1
Abstract:
Disclosed are: a composition having improved water solubility and bioavailability, containing sorafenib and a polymethacrylate copolymer; and a preparation method therefor.
Inventors:
PARK SANG YEOB (KR)
LIM HYE JUNG (KR)
LEE SA WON (KR)
SEO MIN HYO (KR)
LIM HYE JUNG (KR)
LEE SA WON (KR)
SEO MIN HYO (KR)
Application Number:
PCT/KR2018/004997
Publication Date:
November 08, 2018
Filing Date:
April 30, 2018
Export Citation:
Assignee:
SAMYANG BIOPHARMACEUTICALS (KR)
International Classes:
A61K9/20; A61K9/00; A61K9/48; A61K31/44
Domestic Patent References:
| WO2013105895A1 | 2013-07-18 |
Foreign References:
| US20150224060A1 | 2015-08-13 | |||
| EP2801349A1 | 2014-11-12 | |||
| KR101395932B1 | 2014-05-19 |
Other References:
WANG, X.-Q.: "Bioavailability and pharmacokinetics of sorafenib suspension, nanoparticles and nanomatrix for oral administration to rat", INTERNATIONAL JOURNAL OF PHARMACEUTICS, vol. 419, 2011, pages 339 - 346, XP028306649, DOI: doi:10.1016/j.ijpharm.2011.08.003
MANDAL, U. K.: "Gastro-retentive drug delivery systems and their in vivo success; a recent update", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES II, vol. 11, no. 5, 2016, pages 575 - 584, XP055612523
See also references of EP 3620156A4
MANDAL, U. K.: "Gastro-retentive drug delivery systems and their in vivo success; a recent update", ASIAN JOURNAL OF PHARMACEUTICAL SCIENCES II, vol. 11, no. 5, 2016, pages 575 - 584, XP055612523
See also references of EP 3620156A4
Attorney, Agent or Firm:
HANSUNG INTELLECTUAL PROPERTY (KR)
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