Title:
COMPOSITION HAVING VASODILATION ACTIVITY, PROCESS FOR PRODUCING SAME, AND USE OF SAME
Document Type and Number:
WIPO Patent Application WO/2010/092941
Kind Code:
A1
Abstract:
Disclosed are: a composition which has a vasodilation activity and therefore has an alleviation and regression activity on various conditions associated with blood circulation, such as an alleviation activity on blood circulation, an anti-hypertensive activity, and an alleviation or regression activity on shoulder stiffness, head ache, excessive sensitivity to cold and cerebral circulation; a process for producing the composition; and a food, a beverage or a pharmaceutical preparation each having the above-mentioned functions. Specifically disclosed are: a composition having a synergistically improved vasodilation activity, which comprises a fused tannin oligomer component and an organic acid component; a process for producing the composition; and a food, a beverage or a pharmaceutical preparation each having the above-mentioned function.
Inventors:
HIRAYAMA MASAO (JP)
NAKAYAMA KAYOKO (JP)
WATANABE YUSUKE (JP)
AKETA SAIKO (JP)
YOKOYAMA TADAYUKI (JP)
NAMBA MITSURU (JP)
FURUUCHI RYO (JP)
NAKAYAMA KAYOKO (JP)
WATANABE YUSUKE (JP)
AKETA SAIKO (JP)
YOKOYAMA TADAYUKI (JP)
NAMBA MITSURU (JP)
FURUUCHI RYO (JP)
Application Number:
PCT/JP2010/051851
Publication Date:
August 19, 2010
Filing Date:
February 09, 2010
Export Citation:
Assignee:
BOURBON CORP (JP)
HIRAYAMA MASAO (JP)
NAKAYAMA KAYOKO (JP)
WATANABE YUSUKE (JP)
AKETA SAIKO (JP)
YOKOYAMA TADAYUKI (JP)
NAMBA MITSURU (JP)
FURUUCHI RYO (JP)
HIRAYAMA MASAO (JP)
NAKAYAMA KAYOKO (JP)
WATANABE YUSUKE (JP)
AKETA SAIKO (JP)
YOKOYAMA TADAYUKI (JP)
NAMBA MITSURU (JP)
FURUUCHI RYO (JP)
International Classes:
A61K31/353; A61K31/19; A61K31/194; A61K35/74; A61K36/00; A61P9/00; A61P9/08; A61P9/12
Foreign References:
| JPH09173029A | 1997-07-08 | |||
| JP2003524428A | 2003-08-19 | |||
| JP2006087337A | 2006-04-06 | |||
| JP2002291440A | 2002-10-08 | |||
| JPH04248972A | 1992-09-04 | |||
| JP2008156306A | 2008-07-10 | |||
| JP2001046030A | 2001-02-20 | |||
| JP2009500411A | 2009-01-08 | |||
| JP2009501161A | 2009-01-15 | |||
| JP2002255801A | 2002-09-11 |
Other References:
ORTEGA,T. ET AL.: "Influence of grape variety and their phenolic composition on vasorelaxing activity of young red wines", EUR FOOD RES TECHNOL, vol. 227, no. 6, October 2008 (2008-10-01), pages 1641 - 1650
SUGIYAMA,A. ET AL.: "Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat.", NUTR RES, vol. 23, no. 9, September 2003 (2003-09-01), pages 1291 - 1296
TAKAHARA,A. ET AL.: "The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice", BIOL PHARM BULL, vol. 28, no. 4, 1 April 2005 (2005-04-01), pages 754 - 756
HONSHO,S. ET AL.: "A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System: Experimental Evidence in Vivo", BIOL PHARM BULL, vol. 28, no. 7, 1 July 2005 (2005-07-01), pages 1208 - 1210
HONSHO,S. ET AL.: "Effects of a wine vinegar beverage on the renin-angiotensin system in vivo", J PHARMACOL SCI, vol. 97, no. 1, 1 March 2005 (2005-03-01), pages 119P
ATSUSHI SUGIYAMA ET AL.: "Kajitsu Kanren Shokuhin no Kenko Zoshin Koka ni Kansuru Kono Bunseki Shuho no Kaihatsu - San Gaku Kan Renkei no Model Case", COOPERATIVE RESEARCH AND DEVELOPMENT CENTER UNIVERSITY OF YAMANASHI KENKYU SEIKA HOKOKUSHO, March 2005 (2005-03-01), pages 51 - 53
SACHIKO HONSHO ET AL.: "Rat Tekishutsu Kekkan ni Okeru Budosu Inryo no Kekkan Shikan Sayo", FOLIA PHARMACOLOGICA JAPONICA, vol. 125, no. 1, 1 January 2005 (2005-01-01), pages 13P
H.P. VASANTHA RUPASINGHE ET AL.: "Total antioxidant capacity, total phenolic content, mineral elements, and histamine concentrations in wines of different fruit sources", JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol. 20, no. 2, March 2007 (2007-03-01), pages 133 - 137
MAO KAWAMURA ET AL.: "Kakisu no Junkan Kino ni Oyobosu Eikyo ni Tsuite", WAKAYAMA IGAKU, vol. 57, no. 4, 31 December 2006 (2006-12-31), pages 159
IKUHARU MORIOKA ET AL.: "Kakisu ga Kenko ni Oyobosu Eikyo no Ekigakuteki Chosa", WAKAYAMA IGAKU, vol. 59, no. 4, 31 December 2008 (2008-12-31), pages 206 - 207
MATSUTANI,Y. ET AL.: "Persimmon Vinegar Decreased Blood Pressure in Subjects with High-normal Blood Pressure or Hypertension-Single-Blind Crossover TrialPersimmon Vinegar Decreased Blood Pressure in Subjects with High-normal Blood Pressure or Hypertension-Single-Blind Crossover Trial", CIRC J, vol. 70, no. 1, 1 March 2006 (2006-03-01), pages 508
CHIGUSA NAKAMURA ET AL.: "Kakisu Iri Mikan Juice no In'yo ni yori Koketsuatsu Sha no Ketsuatsu wa Teika suru", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 97, 20 February 2008 (2008-02-20), pages 140
WADA,L. ET AL.: "Antioxidant Activity and Phenolic Content of Oregon Caneberries.", J AGRIC FOOD CHEM, vol. 50, no. 12, 5 June 2002 (2002-06-05), pages 3495 - 3500
SUGIYAMA,A. ET AL.: "Acute cardiovascular effects of a new beverage made of wine vinegar and grape juice, assessed using an in vivo rat.", NUTR RES, vol. 23, no. 9, September 2003 (2003-09-01), pages 1291 - 1296
TAKAHARA,A. ET AL.: "The Endothelium-Dependent Vasodilator Action of a New Beverage Made of Red Wine Vinegar and Grape Juice", BIOL PHARM BULL, vol. 28, no. 4, 1 April 2005 (2005-04-01), pages 754 - 756
HONSHO,S. ET AL.: "A Red Wine Vinegar Beverage can Inhibit the Renin-Angiotensin System: Experimental Evidence in Vivo", BIOL PHARM BULL, vol. 28, no. 7, 1 July 2005 (2005-07-01), pages 1208 - 1210
HONSHO,S. ET AL.: "Effects of a wine vinegar beverage on the renin-angiotensin system in vivo", J PHARMACOL SCI, vol. 97, no. 1, 1 March 2005 (2005-03-01), pages 119P
ATSUSHI SUGIYAMA ET AL.: "Kajitsu Kanren Shokuhin no Kenko Zoshin Koka ni Kansuru Kono Bunseki Shuho no Kaihatsu - San Gaku Kan Renkei no Model Case", COOPERATIVE RESEARCH AND DEVELOPMENT CENTER UNIVERSITY OF YAMANASHI KENKYU SEIKA HOKOKUSHO, March 2005 (2005-03-01), pages 51 - 53
SACHIKO HONSHO ET AL.: "Rat Tekishutsu Kekkan ni Okeru Budosu Inryo no Kekkan Shikan Sayo", FOLIA PHARMACOLOGICA JAPONICA, vol. 125, no. 1, 1 January 2005 (2005-01-01), pages 13P
H.P. VASANTHA RUPASINGHE ET AL.: "Total antioxidant capacity, total phenolic content, mineral elements, and histamine concentrations in wines of different fruit sources", JOURNAL OF FOOD COMPOSITION AND ANALYSIS, vol. 20, no. 2, March 2007 (2007-03-01), pages 133 - 137
MAO KAWAMURA ET AL.: "Kakisu no Junkan Kino ni Oyobosu Eikyo ni Tsuite", WAKAYAMA IGAKU, vol. 57, no. 4, 31 December 2006 (2006-12-31), pages 159
IKUHARU MORIOKA ET AL.: "Kakisu ga Kenko ni Oyobosu Eikyo no Ekigakuteki Chosa", WAKAYAMA IGAKU, vol. 59, no. 4, 31 December 2008 (2008-12-31), pages 206 - 207
MATSUTANI,Y. ET AL.: "Persimmon Vinegar Decreased Blood Pressure in Subjects with High-normal Blood Pressure or Hypertension-Single-Blind Crossover TrialPersimmon Vinegar Decreased Blood Pressure in Subjects with High-normal Blood Pressure or Hypertension-Single-Blind Crossover Trial", CIRC J, vol. 70, no. 1, 1 March 2006 (2006-03-01), pages 508
CHIGUSA NAKAMURA ET AL.: "Kakisu Iri Mikan Juice no In'yo ni yori Koketsuatsu Sha no Ketsuatsu wa Teika suru", THE JOURNAL OF THE JAPANESE SOCIETY OF INTERNAL MEDICINE, vol. 97, 20 February 2008 (2008-02-20), pages 140
WADA,L. ET AL.: "Antioxidant Activity and Phenolic Content of Oregon Caneberries.", J AGRIC FOOD CHEM, vol. 50, no. 12, 5 June 2002 (2002-06-05), pages 3495 - 3500
Attorney, Agent or Firm:
TSUJII Koichi et al. (JP)
辻居 Koichi (JP)
辻居 Koichi (JP)
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