Title:
COMPOSITION FOR IMPROVING, PREVENTING OR TREATING SKIN DISEASE COMPRISING INDUCED PLURIPOTENCY STEM CELL-DERIVED MESENCHYMAL STEM CELLS PRETREATED WITH INTERFERON GAMMA AND EXOSOMES DERIVED THEREFROM
Document Type and Number:
WIPO Patent Application WO/2019/135645
Kind Code:
A1
Abstract:
The present invention may provide a method for producing induced pluripotency stem cell-derived mesenchymal stem cells (IFNγ-iMSC) pretreated with interferon-gamma; induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon-gamma prepared by the method; a pharmaceutical composition for preventing or treating skin diseases, and a cosmetic composition for preventing or improving skin diseases, comprising culture thereof or exosome (IFNγ-iMSC-exo) isolated therefrom as an active ingredient. When the composition of the present invention is used, it is possible to provide a composition for skin diseases and a stem cell therapeutic agent, which have an improved immunomodulating function over conventional mesenchymal stem cells.
Inventors:
KIM SUE (KR)
YU JIN HO (KR)
YU JIN HO (KR)
Application Number:
PCT/KR2019/000181
Publication Date:
July 11, 2019
Filing Date:
January 07, 2019
Export Citation:
Assignee:
ASAN FOUND (KR)
UNIV ULSAN FOUND IND COOP (KR)
UNIV ULSAN FOUND IND COOP (KR)
International Classes:
C12N5/0775; A61K8/98; A61K35/28; A61P17/00; A61P17/06; A61Q19/00
Domestic Patent References:
| WO2009105044A1 | 2009-08-27 |
Foreign References:
| KR20160037113A | 2016-04-05 | |||
| CN107245472A | 2017-10-13 | |||
| KR20130073794A | 2013-07-03 | |||
| KR20180001979A | 2018-01-05 |
Other References:
YU , B. ET AL.: "Exosomes Derived from Mesenchymal Stem Cells", INT. J. MOL. SCI., vol. 15, 2014, pages 4142 - 4157, XP055407121
"Remington's Pharmaceutical Sciences", 1995
See also references of EP 3736327A4
"Remington's Pharmaceutical Sciences", 1995
See also references of EP 3736327A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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