COMPOSITION FOR IMPROVING RESPIRATORY DISEASE INCLUDING EXTRACT OF PALIURUS RAMOSISSIMUS (LOUR.) POIR.

WIPO Patent Application WO/2020/050633

A1

The present invention discloses a composition for alleviating lung diseases, such as asthma and chronic obstructive pulmonary disease, using the extracts of Paliurus ramosissimus (Lour.) Poir, Rosa davurica Pall., Picrasma quassioides, Camellia sinensis, Chrysosplenium grayanum, Reynoutria japonica, Pseudocydonia sinensis, Hydrangea serrata, and/or Euonymus alatus. The extracts of Paliurus ramosissimus (Lour.) Poir, Rosa davurica Pall., Picrasma quassioides, Camellia sinensis, Chrysosplenium grayanum, Reynoutria japonica, Pseudocydonia sinensis, Hydrangea serrata, and/or Euonymus alatus have the activities of inhibiting the netosis activation of neutrophil extracellular traps induced by phorbol myristate acetate (PMA), inhibiting the expression of IL-8, an inflammatory cytokine by CSE of NCI-H292 cells, a bronchial epithelial cell line producing mucus, and inhibiting the expression of MIP-2, an inflammatory cytokine of alveolar macrophages MH-S cells activated by CES and LPS (lipopolysaccaride). In addition, the extracts have the activities of inhibiting lung tissue damage in the mouse model of CSE and PPE induced respiratory disease, inhibiting immune cell infiltration of total cell, macrophages, lymphocytes, eosinophils, and neutrophils in BALF, and inhibiting the secretion of inflammatory cytokines and chemokines in BALF and lung tissue.

SHIN HEE SOON (KR)
KIM SEUNG YONG (KR)
SHIN DONG UK (KR)
EOM JI EUN (KR)
LEE SO YOUNG (KR)
JUNG SUN YOUNG (KR)
CHOI DAE WOON (KR)
NAM YOUNG DO (KR)
PARK SO LIM (KR)

PCT/KR2019/011432

March 12, 2020

September 04, 2019

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KOREA FOOD RES INST (KR)

A61K36/704; A23L33/105; A61K36/47; A61P11/00; A61P11/06; A61P29/00; A61P37/08

WO2015105373A1

2015-07-16

KR100824970B1	2008-04-28
KR20140043610A	2014-04-10
KR20150026579A	2015-03-11
KR20120087735A	2012-08-07
KR20110036317A	2011-04-07
KR20110068095A	2011-06-22

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