COMPOSITION FOR IMPROVING SKIN WHITENING OR AMELIORATING THERMAL SKIN AGING COMPRISING 8-METHOXYBUTIN

WIPO Patent Application WO/2019/088727

A1

The present invention relates to a composition for improving skin whitening or ameliorating thermal skin aging comprising 8-methoxybutin or an acceptable salt thereof as an active ingredient. The composition exhibited an effect of increasing the expression of heat shock protein 70 (HSP70), which is known to prevent thermal skin aging, and inhibiting the activity of tyrosinase associated with skin pigmentation, without exhibiting cytotoxicity. Thus, the composition comprising 8-methoxybutin or an acceptable salt thereof as an active ingredient may be utilized as a cosmetic composition, an external preparation for skin or a functional health food for improving skin whitening or ameliorating thermal skin aging.

KIM KYONG TAI (KR)
KIM HYO JIN (KR)
OH EUNJI (KR)
BAEK NAM IN (KR)
KIM HYOUNG-GEUN (KR)

PCT/KR2018/013172

May 09, 2019

November 01, 2018

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POSTECH ACAD IND FOUND (KR)

A61K8/49; A23L33/10; A61K31/352; A61Q19/02

CN102961281A	2013-03-13
KR20090053496A	2009-05-27
JPH07223933A	1995-08-22
JPH07118151A	1995-05-09

OKADA ET AL.: "Isolation and Identification of Flavonoids from Coreopsis Lanceolata L. Petals", NATURAL PRODUCT RESEARCH, vol. 28, no. 3, 2014, pages 201 - 204, XP055614896
"Thermal aging: A new concept of skin aging", J. DERMATOLOGICAL SCI., vol. 2, 2006, pages S 13 - S22
PHOTODERMATOL PHOTOIMMUNOL PHOTOMED, vol. 22, 2006, pages 148 - 152
See also references of EP 3705110A4

SON, Min (KR)

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