Title:
COMPOSITION INCLUDING VERBENONE DERIVATIVE FOR PREVENTING OR ALLEVIATING SIDE EFFECTS OF REPERFUSION PROCEDURE
Document Type and Number:
WIPO Patent Application WO/2016/122289
Kind Code:
A3
Abstract:
The present invention relates to a pharmaceutical composition for preventing or alleviating side effects caused by a reperfusion procedure. More specifically, the present invention relates to a composition including a verbenone derivative having the structure of Chemical Formula 1 or a pharmaceutically acceptable salt thereof for preventing or alleviating side effects caused by a reperfusion procedure, and a method of preventing or alleviating side effects caused by the reperfusion procedure, by administering the verbenone derivative or a pharmaceutically acceptable salt thereof before, concurrently with or after the reperfusion procedure. Furthermore, the present invention relates to a composition including a verbenone derivative having the structure of Chemical Formula 1 or a pharmaceutically acceptable salt thereof for treating cerebrovascular diseases, arteriosclerosis or cardiovascular diseases in a patient who has been subjected to the reperfusion procedure and a method for treating cerebrovascular diseases, arteriosclerosis or cardiovascular diseases by administering the verbenone derivative or a pharmaceutically acceptable salt thereof before, concurrently with or after the reperfusion procedure.
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Inventors:
KIM WON KI (KR)
PAHK KISOO (KR)
SONG HWA YOUNG (KR)
JU CHUNG (KR)
PAHK KISOO (KR)
SONG HWA YOUNG (KR)
JU CHUNG (KR)
Application Number:
PCT/KR2016/001093
Publication Date:
October 27, 2016
Filing Date:
February 01, 2016
Export Citation:
Assignee:
UNIV KOREA RES & BUS FOUND (KR)
International Classes:
A61K31/122; A61K31/13; A61K31/38; A61K31/435
Foreign References:
| KR20130139771A | 2013-12-23 | |||
| KR20140031568A | 2014-03-13 | |||
| KR100366982B1 | 2003-08-02 |
Other References:
JU, C. ET AL.: "Discovery of Novel (1 S)-(-)-verbenone Derivatives with Anti-oxidant and Anti-ischemic Effects", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 23, no. 19, 2013, pages 5421 - 5425, XP028707922, [retrieved on 20130725]
JU, C. ET AL.: "Up-regulation of Astroglial Heme Oxygenase-1 by a Synthetic (S)-verbenone Derivative LMT-335 Ameliorates Oxygen-glucose Deprivation- evoked Injury in Cortical Neurons", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMINICATIONS, vol. 431, no. 3, 2013, pages 484 - 489, XP028980093, [retrieved on 20130116]
JU, C. ET AL.: "Up-regulation of Astroglial Heme Oxygenase-1 by a Synthetic (S)-verbenone Derivative LMT-335 Ameliorates Oxygen-glucose Deprivation- evoked Injury in Cortical Neurons", BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMINICATIONS, vol. 431, no. 3, 2013, pages 484 - 489, XP028980093, [retrieved on 20130116]
Attorney, Agent or Firm:
LEE, Cheo Young et al. (123 Teheran-roGangnam-gu, Seoul, KR)
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