Title:
COMPOSITION FOR INCREASING EXPRESSION OF PGC-1α
Document Type and Number:
WIPO Patent Application WO/2017/123066
Kind Code:
A1
Abstract:
The present invention relates to a composition for preventing or treating diseases or symptoms associated with a reduction in the expression of peroxisome proliferator-activated receptor coactivator 1-alpha (PGC-1α), the composition containing, as an active ingredient, a compound represented by the following general formula I, a salt thereof, or a solvate thereof.
Inventors:
KANG SEUNG WOO (KR)
Application Number:
PCT/KR2017/000505
Publication Date:
July 20, 2017
Filing Date:
January 13, 2017
Export Citation:
Assignee:
BENEBIOSIS CO LTD (KR)
International Classes:
A61K31/7016; A23L33/10; A61K8/14; A61K8/60; A61K9/127; A61K9/51; A61Q19/08; C07H3/04; C07H13/02
Foreign References:
| KR20100014098A | 2010-02-10 |
Other References:
LIANG, H. ET AL.: "PGC-1alpha: a Key Regulator of Energy Metabolism", ADVANCES IN PHYSIOLOGY EDUCATION, vol. 30, 2006, pages 145 - 151, XP055214165
TARR, A.J. ET AL.: "The Prebiotics 3' Sialyllactose and 6' Sialyllactose Diminish Stressor-induced Anxiety-like Behavior and Colonic Microbiota Alterations: Evidence for Effects on the Gut-brain Axis", BRAIN, BEHAVIOR, AND IMMUNITY, vol. 50, 2015, pages 166 - 177, XP029300005
YONEKAWA, T. ET AL.: "Sialyllactose Ameliorates Myopathic Phenotypes in Symptomatic GNE Myopathy Model Mice", BRAIN, vol. 137, 2014, pages 2670 - 2679, XP055275736
ZHU, L. ET AL.: "PGC-1alpha is a Key Regulator of Glucose-induced Proliferation and Migration in Vascular Smooth Muscle Cells", PLOS ONE, vol. 4, no. 1, 2009, pages 1 - 7, XP055535737
XIONG ET AL., CELL REPORTS, vol. 12, 2015, pages 1391 - 1399
GALLUZZI, L.; MAIURI, M.C.; VITALE, I.; ZISCHKA, H.; CASTEDO, M.; ZITVOGEL, L.; KROEMER, G.: "Cell death modalities: classification and pathophysiological implications", CELL DEATH DIFFER., vol. 14, 2007, pages 1237 - 1243, XP055140836, DOI: doi:10.1038/sj.cdd.4402148
CHIPUK, J.E.; MOLDOVEANU, T.; LLAMBI, F.; PARSONS, M.J.; GREEN, D.R.: "The BCL-2 family reunion", MOL. CELL, vol. 37, 2010, pages 299 - 310, XP055301801, DOI: doi:10.1016/j.molcel.2010.01.025
YOULE, R.J.; STRASSER, A.: "The BCL-2 protein family: opposing activities that mediate cell death", NAT. REV. MOL. CELL BIOL., vol. 9, 2008, pages 47 - 59, XP009166365, DOI: doi:10.1038/nrm2308
FADEEL, B.; ORRENIUS, S.: "Apoptosis: a basic biological phenomenon with wide ranging implications in human disease", J. INTERN. MED., vol. 258, 2005, pages 479 - 517
ALECK W.E. JONES; ZHI YAO; JOSE MIGUEL VICENCIO: "Agnieszka Karkucinska-Wieckowska, Gyorgy Szabadkai, 2012. PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signaling", MITOCHONDRION, vol. 12, 2012, pages 86 - 99
LIN, J.; SPIEGELMAN, B.M. ET AL.: "Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-lalpha null mice", CELL, vol. 119, 2004, pages 121 - 135, XP002550778, DOI: doi:10.1016/j.cell.2004.09.013
LEONE, T.C.; LEHMAN, J.J.; FINCK, B.N.; SCHAEFFER, P.J.; WENDE, A.R.; BOUDINA, S.; COURTOIS, M.; WOZNIAK, D.F.; SAMBANDAM, N.; BER: "PGC-lalpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis", PLOS BIOL., vol. 3, 2005, pages e101
CHATURVEDI RK; FLINT BEAL M: "Mitochondrial diseases of the brain", FREE RADIC BIOL MED, vol. 63, 2013, pages 1 - 29, XP055119514, DOI: doi:10.1016/j.freeradbiomed.2013.03.018
KATSOURI L; PARR C; BOGDANOVIC N; WILLEM M; SASTRE M: "PPARgamma co- activator-lalpha (PGC-lalpha) reduces amyloid-beta generation through a PPARgamma-dependent mechanism", J ALZHEIMERS DIS, vol. 25, 2011, pages 151 - 162
QIN W; HAROUTUNIAN V; KATSEL P; CARDOZO CP; HO L; BUXBAUM JD; PASINETTI GM: "PGC-lalpha expression decreases in the Alzheimer disease brain as a function of dementia", ARCH NEUROL, vol. 66, 2009, pages 352 - 361
WANG R; LI JJ; DIAO S; KWAK YD; LIU L; ZHI L; BUELER H; BHAT NR; WILLIAMS RW; PARK EA ET AL.: "Metabolic stress modulates Alzheimer's beta secretase gene transcription via SIRT1-PPARgamma-PGC-1 in neurons", CELL METAB, vol. 17, 2013, pages 685 - 694
CLARK, J.; REDDY, S.; ZHENG, K.; BETENSKY, R.; SIMON, D.: "Association of PGC-lalpha polymorphisms with age of onset and risk of Parkinson's disease", BMC MED. GENET., vol. 12, 2011, pages 69, XP021099912, DOI: doi:10.1186/1471-2350-12-69
WEYDT, P.; SOYAL, S.; GELLERA, C.; DIDONATO, S.; WEIDINGER, C.; OBERKOFLER, H.; LANDWEHRMEYER, G.B.; PATSCH, W.: "The gene coding for PGC-lalpha modifies age at onset in Huntington's Disease", MOL. NEURODEGENER., vol. 4, 2009, pages 3, XP021052334, DOI: doi:10.1186/1750-1326-4-3
CUI, L.; JEONG, H.; BOROVECKI, F.; PARKHURST, C.N.; TANESE, N.; KRAINC, D.: "Transcriptional repression of PGC-lalpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration", CELL, vol. 127, 2006, pages 59 - 69
RANGANATHAN, S.; HARMISON, G.G.; MEYERTHOLEN, K.; PENNUTO, M.; BURNETT, B.G.; FISCHBECK, K.H.: "Mitochondrial abnormalities in spinal and bulbar muscular atrophy", HUM. MOL. GENET., vol. 18, 2009, pages 27 - 42
WEYDT, P.; PINEDA, V.V.; TORRENCE, A.E.; LIBBY, R.T.; SATTERFIELD, T.F.; LAZAROWSKI, E.R.; GILBERT, M.L.; MORTON, G.J.; BAMMLER, T: "Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-lalpha in Huntington's disease neurodegeneration", CELL METAB., vol. 4, 2006, pages 349 - 362
XIANG, Z.; VALENZA, M.; CUI, L.; LEONI, V.; JEONG, H.-K.; BRILLI, E.; ZHANG, J.; PENG, Q.; DUAN, W.; REEVES, S.A.: "Peroxisome-proliferator-activated receptor gamma coactivator la contributes to dysmyelination in experimental models of Huntington's disease", J. NEUROSCI., vol. 31, 2011, pages 9544 - 9553
ZHENG, B.; LIAO, Z.; LOCASCIO, J. J.; LESNIAK, K. A.; RODERICK, S. S.; WATT, M. L.; EKLUND, A. C.; ZHANG-JAMES, Y.; KIM, P. D.; HA: "PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease", SCI. TRANSL. MED., vol. 2, 2010, pages 52ra73
CHATURVEDI, R.K.; ADHIHETTY, P.; SHUKLA, S.; HENNESSY, T.; CALINGASAN, N.; YANG, L.; STARKOV, A.; KIAEI, M.; CANNELLA, M.; SASSONE: "Impaired PGC-lalpha function in muscle in Huntington's disease", HUM. MOL. GENET., vol. 18, 2009, pages 3048 - 3065
ZHAO, W.; VARGHESE, M.; YEMUL, S.; PAN, Y.; CHENG, A.; MARANO, P.; HASSAN, S.; VEMPATI, P.; CHEN, F.; QIAN, X.: "Peroxisome proliferator activator receptor gamma coactivator-lalpha (PGC-lalpha) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis", MOL. NEURODEGENER., vol. 6, 2011, pages 51
ST-PIERRE, J.; LIN, J.; KRAUSS, S.; TARR, P.T.; YANG, R.; NEWGARD, C.B.; SPIEGELMAN, B.M.: "Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-lalpha and PGC-lbeta) in muscle cells", J. BIOL.CHEM., vol. 278, 2003, pages 26597 - 26603
COWELL, R.M.; TALATI, P.; BLAKE, K.R.; MEADOR-WOODRUFF, J.H.; RUSSELL, J.W.: "Identification of novel targets for PGC-lalpha and histone deacetylase inhibitors in neuroblastoma cells", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 379, 2009, pages 578 - 582
ST-PIERRE, J.; DRORI, S.; ULDRY, M.; SILVAGGI, J.M.; RHEE, J.; JAGER, S.; HANDSCHIN, C.; ZHENG, K.; LIN, J.; YANG, W.: "Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators", CELL, vol. 127, 2006, pages 397 - 408
VALLE, I.; ALVAREZ-BARRIENTOS, A.; ARZA, E.; LAMAS, S.; MONSALVE, M.: "PGC-lalpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells", CARDIOVASC. RES., vol. 66, 2005, pages 562 - 573
XIONG, S.; PATRUSHEV N.; FOROUUZANDEH, F.; HILENSKI, L.; ALEXANDER, R.W.: "PGC-1a modulates telomere function and DNA damage inprotecting against age-related chronic diseases", CELL REPORT, vol. 12, 2015, pages 1391 - 1399
BORNIQUEL, S.; VALLE, I.; CADENAS, S.; LAMAS, S.; MONSALVE, M.: "Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-lalpha", THE FASEB JOURNAL: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, vol. 20, 2006, pages 1889 - 1891
LAI, L.; LEONE, T.C.; ZECHNER, C.; SCHAEFFER, P.J.; KELLY, S.M.; FLANAGAN, D.P.; MEDEIROS, D.M.; KOVACS, A.; KELLY, D.P.: "Transcriptional coactivators PGC-lalpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart", GENES DEV., vol. 22, 2008, pages 1948 - 1961
GARNIER, A.; FORTIN, D.; DELOMENIE, C.; MOMKEN, I.; VEKSLER, V.; VENTURA-CLAPIER, R.: "Depressed mitochondrial transcription factors and oxidative oxidative capacity in rat failing cardiac and skeletal muscles", J. PHYSIOL., vol. 551, 2003, pages 491 - 501, XP008042859, DOI: doi:10.1113/jphysiol.2003.045104
LJUBICIC V; JOSEPH A; SALEEM A ET AL.: "Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging", BIOCHIM BIOPHYS ACTA, vol. 1800, 2010, pages 223 - 234, XP026911631, DOI: doi:10.1016/j.bbagen.2009.07.031
GOUSPILLOU G; PICARD M; GODIN R; BURELLE Y; HEPPLE R: "Role of peroxisome proliferative activated receptor gamma coactivator 1-alpha (PGC-la) in denervation-induced atrophy in aged muscle: facts and hypotheses", LONGEV HEALTHSPAN, vol. 2, 2013, pages 13
JOHNSON ML; ROBINSON MM; NAIR KS: "Skeletal muscle aging and the mitochondrion", TRENDS ENDOCRIN MET, vol. 24, 2013, pages 247 - 256
MARZETTI E; CALVANI R; CESARI M ET AL.: "Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials", INT J BIOCHEM CELL BIOL, vol. 45, 2013, pages 2288 - 2301, XP028699825, DOI: doi:10.1016/j.biocel.2013.06.024
CALVANI R; JOSEPH A; ADHIHETTY PJ ET AL.: "Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy", BIOL CHEM, vol. 394, 2013, pages 393 - 414
WALLACE DC: "A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine", ANNU REV GENET, vol. 39, 2005, pages 359, XP055169259, DOI: doi:10.1146/annurev.genet.39.110304.095751
FINCK BN; KELLY DP: "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease", J CLIN INVEST, vol. 116, 2006, pages 615 - 622
TINA WENZ; SUSANA G. ROSSI; RICHARD L. ROTUNDO; BRUCE M. SPIEGELMAN; CARLOS T. MORAES: "Increased muscle PGC-1a expression protects from sarcopenia and metabolic disease during aging", PNAS, vol. 106, 2009, pages 20405 - 20410
ROLFE, D. F.; BROWN, G. C.: "Cellular energy utilization and molecular origin of standard metabolic rate in mammals", PHYSIOL. REV., vol. 77, 1997, pages 731 - 758, XP008022700
JASTROCH, M.; DIVAKARUNI, A. S.; MOOKERJEE, S.; TREBERG, J. R.; BRAND, M. D.: "Mitochondrial proton and electron leaks", ESSAYS BIOCHEM., vol. 47, 2010, pages 53 - 67
FUKUI Y; MASUI S; OSADA S; UMESONO K; MOTOJIMA K: "A new thiazolidinedione, NC-2100, which is a weak PPAR-g activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice", DIABETES, vol. 49, 2000, pages 759 - 767, XP002990563, DOI: doi:10.2337/diabetes.49.5.759
WILSON-FRITCH L; NICOLORO S; CHOUINARD M; LAZAR MA; CHUI PC; LESZYK J; STRAUBHAAR J; CZECH MP; CORVERA S: "Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone", J CLIN INVEST, vol. 114, 2004, pages 1281 - 1289, XP002505380, DOI: doi:10.1172/JCI200421752
QUINLAN, C. L.; TREBERG, J. R.; BRAND, M. D.: "Handbook of the Biology of Aging", 2011, ACADEMIC PRESS, article "Mechanisms of mitochondrial free radical production and their relationship to the aging process", pages: 47 - 61
SAHIN, E.; COLLA, S.; LIESA, M.; MOSLEHI, J.; MU''LLER, F. L.; GUO, M.; COOPER, M.; KOTTON, D.; FABIAN, A. J.; WALKEY, C. ET AL.: "Telomere dysfunction induces metabolic and mitochondrial compromise", NATURE, vol. 470, 2011, pages 359 - 365
KUJOTH, G. C.; HIONA, A.; PUGH, T. D.; SOMEYA, S.; PANZER, K.; WOHLGEMUTH, S. E.; HOFER, T.; SEO, A. Y.; SULLIVAN, R.; JOBLING, W.: "Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging", SCIENCE, vol. 309, 2005, pages 481 - 484
TRIFUNOVIC, A.; WREDENBERG, A.; FALKENBERG, M.; SPELBRINK, J. N.; ROVIO, A. T.; BRUDER, C. E.; BOHLOOLY-Y, M.; GIDLO''F, S.; OLDFO: "Premature ageing in mice expressing defective mitochondrial DNA polymerase", NATURE, vol. 429, 2004, pages 417 - 423
LIN, J.; WU, H.; TARR, P. T.; ZHANG, C. Y.; WU, Z.; BOSS, 0.; MICHAEL, L. F.; PUIGSERVER, P.; ISOTANI, E.; OLSON, E. N. ET AL.: "Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres", NATURE, vol. 418, 2002, pages 797 - 801, XP002345819, DOI: doi:10.1038/nature00904
DILLON, L. M.; WILLIAMS, S. L.; HIDA, A.; PEACOCK, J. D.; PROLLA, T. A.; LINCOLN, J.; MORAES, C. T.: "Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse", HUM. MOL. GENET., vol. 21, 2012, pages 2288 - 2297
WENZ, T.; ROSSI, S. G.; ROTUNDO, R. L.; SPIEGELMAN, B. M.; MORAES, C. T.: "Increased muscle PGC-lalpha expression protects from sarcopenia and metabolic disease during aging", PROC. NATL. ACAD. SCI. USA, vol. 106, 2009, pages 20405 - 20410
See also references of EP 3403655A4
TARR, A.J. ET AL.: "The Prebiotics 3' Sialyllactose and 6' Sialyllactose Diminish Stressor-induced Anxiety-like Behavior and Colonic Microbiota Alterations: Evidence for Effects on the Gut-brain Axis", BRAIN, BEHAVIOR, AND IMMUNITY, vol. 50, 2015, pages 166 - 177, XP029300005
YONEKAWA, T. ET AL.: "Sialyllactose Ameliorates Myopathic Phenotypes in Symptomatic GNE Myopathy Model Mice", BRAIN, vol. 137, 2014, pages 2670 - 2679, XP055275736
ZHU, L. ET AL.: "PGC-1alpha is a Key Regulator of Glucose-induced Proliferation and Migration in Vascular Smooth Muscle Cells", PLOS ONE, vol. 4, no. 1, 2009, pages 1 - 7, XP055535737
XIONG ET AL., CELL REPORTS, vol. 12, 2015, pages 1391 - 1399
GALLUZZI, L.; MAIURI, M.C.; VITALE, I.; ZISCHKA, H.; CASTEDO, M.; ZITVOGEL, L.; KROEMER, G.: "Cell death modalities: classification and pathophysiological implications", CELL DEATH DIFFER., vol. 14, 2007, pages 1237 - 1243, XP055140836, DOI: doi:10.1038/sj.cdd.4402148
CHIPUK, J.E.; MOLDOVEANU, T.; LLAMBI, F.; PARSONS, M.J.; GREEN, D.R.: "The BCL-2 family reunion", MOL. CELL, vol. 37, 2010, pages 299 - 310, XP055301801, DOI: doi:10.1016/j.molcel.2010.01.025
YOULE, R.J.; STRASSER, A.: "The BCL-2 protein family: opposing activities that mediate cell death", NAT. REV. MOL. CELL BIOL., vol. 9, 2008, pages 47 - 59, XP009166365, DOI: doi:10.1038/nrm2308
FADEEL, B.; ORRENIUS, S.: "Apoptosis: a basic biological phenomenon with wide ranging implications in human disease", J. INTERN. MED., vol. 258, 2005, pages 479 - 517
ALECK W.E. JONES; ZHI YAO; JOSE MIGUEL VICENCIO: "Agnieszka Karkucinska-Wieckowska, Gyorgy Szabadkai, 2012. PGC-1 family coactivators and cell fate: Roles in cancer, neurodegeneration, cardiovascular disease and retrograde mitochondria-nucleus signaling", MITOCHONDRION, vol. 12, 2012, pages 86 - 99
LIN, J.; SPIEGELMAN, B.M. ET AL.: "Defects in adaptive energy metabolism with CNS-linked hyperactivity in PGC-lalpha null mice", CELL, vol. 119, 2004, pages 121 - 135, XP002550778, DOI: doi:10.1016/j.cell.2004.09.013
LEONE, T.C.; LEHMAN, J.J.; FINCK, B.N.; SCHAEFFER, P.J.; WENDE, A.R.; BOUDINA, S.; COURTOIS, M.; WOZNIAK, D.F.; SAMBANDAM, N.; BER: "PGC-lalpha deficiency causes multi-system energy metabolic derangements: muscle dysfunction, abnormal weight control and hepatic steatosis", PLOS BIOL., vol. 3, 2005, pages e101
CHATURVEDI RK; FLINT BEAL M: "Mitochondrial diseases of the brain", FREE RADIC BIOL MED, vol. 63, 2013, pages 1 - 29, XP055119514, DOI: doi:10.1016/j.freeradbiomed.2013.03.018
KATSOURI L; PARR C; BOGDANOVIC N; WILLEM M; SASTRE M: "PPARgamma co- activator-lalpha (PGC-lalpha) reduces amyloid-beta generation through a PPARgamma-dependent mechanism", J ALZHEIMERS DIS, vol. 25, 2011, pages 151 - 162
QIN W; HAROUTUNIAN V; KATSEL P; CARDOZO CP; HO L; BUXBAUM JD; PASINETTI GM: "PGC-lalpha expression decreases in the Alzheimer disease brain as a function of dementia", ARCH NEUROL, vol. 66, 2009, pages 352 - 361
WANG R; LI JJ; DIAO S; KWAK YD; LIU L; ZHI L; BUELER H; BHAT NR; WILLIAMS RW; PARK EA ET AL.: "Metabolic stress modulates Alzheimer's beta secretase gene transcription via SIRT1-PPARgamma-PGC-1 in neurons", CELL METAB, vol. 17, 2013, pages 685 - 694
CLARK, J.; REDDY, S.; ZHENG, K.; BETENSKY, R.; SIMON, D.: "Association of PGC-lalpha polymorphisms with age of onset and risk of Parkinson's disease", BMC MED. GENET., vol. 12, 2011, pages 69, XP021099912, DOI: doi:10.1186/1471-2350-12-69
WEYDT, P.; SOYAL, S.; GELLERA, C.; DIDONATO, S.; WEIDINGER, C.; OBERKOFLER, H.; LANDWEHRMEYER, G.B.; PATSCH, W.: "The gene coding for PGC-lalpha modifies age at onset in Huntington's Disease", MOL. NEURODEGENER., vol. 4, 2009, pages 3, XP021052334, DOI: doi:10.1186/1750-1326-4-3
CUI, L.; JEONG, H.; BOROVECKI, F.; PARKHURST, C.N.; TANESE, N.; KRAINC, D.: "Transcriptional repression of PGC-lalpha by mutant huntingtin leads to mitochondrial dysfunction and neurodegeneration", CELL, vol. 127, 2006, pages 59 - 69
RANGANATHAN, S.; HARMISON, G.G.; MEYERTHOLEN, K.; PENNUTO, M.; BURNETT, B.G.; FISCHBECK, K.H.: "Mitochondrial abnormalities in spinal and bulbar muscular atrophy", HUM. MOL. GENET., vol. 18, 2009, pages 27 - 42
WEYDT, P.; PINEDA, V.V.; TORRENCE, A.E.; LIBBY, R.T.; SATTERFIELD, T.F.; LAZAROWSKI, E.R.; GILBERT, M.L.; MORTON, G.J.; BAMMLER, T: "Thermoregulatory and metabolic defects in Huntington's disease transgenic mice implicate PGC-lalpha in Huntington's disease neurodegeneration", CELL METAB., vol. 4, 2006, pages 349 - 362
XIANG, Z.; VALENZA, M.; CUI, L.; LEONI, V.; JEONG, H.-K.; BRILLI, E.; ZHANG, J.; PENG, Q.; DUAN, W.; REEVES, S.A.: "Peroxisome-proliferator-activated receptor gamma coactivator la contributes to dysmyelination in experimental models of Huntington's disease", J. NEUROSCI., vol. 31, 2011, pages 9544 - 9553
ZHENG, B.; LIAO, Z.; LOCASCIO, J. J.; LESNIAK, K. A.; RODERICK, S. S.; WATT, M. L.; EKLUND, A. C.; ZHANG-JAMES, Y.; KIM, P. D.; HA: "PGC-1a, a potential therapeutic target for early intervention in Parkinson's disease", SCI. TRANSL. MED., vol. 2, 2010, pages 52ra73
CHATURVEDI, R.K.; ADHIHETTY, P.; SHUKLA, S.; HENNESSY, T.; CALINGASAN, N.; YANG, L.; STARKOV, A.; KIAEI, M.; CANNELLA, M.; SASSONE: "Impaired PGC-lalpha function in muscle in Huntington's disease", HUM. MOL. GENET., vol. 18, 2009, pages 3048 - 3065
ZHAO, W.; VARGHESE, M.; YEMUL, S.; PAN, Y.; CHENG, A.; MARANO, P.; HASSAN, S.; VEMPATI, P.; CHEN, F.; QIAN, X.: "Peroxisome proliferator activator receptor gamma coactivator-lalpha (PGC-lalpha) improves motor performance and survival in a mouse model of amyotrophic lateral sclerosis", MOL. NEURODEGENER., vol. 6, 2011, pages 51
ST-PIERRE, J.; LIN, J.; KRAUSS, S.; TARR, P.T.; YANG, R.; NEWGARD, C.B.; SPIEGELMAN, B.M.: "Bioenergetic analysis of peroxisome proliferator-activated receptor gamma coactivators 1alpha and 1beta (PGC-lalpha and PGC-lbeta) in muscle cells", J. BIOL.CHEM., vol. 278, 2003, pages 26597 - 26603
COWELL, R.M.; TALATI, P.; BLAKE, K.R.; MEADOR-WOODRUFF, J.H.; RUSSELL, J.W.: "Identification of novel targets for PGC-lalpha and histone deacetylase inhibitors in neuroblastoma cells", BIOCHEM. BIOPHYS. RES. COMMUN., vol. 379, 2009, pages 578 - 582
ST-PIERRE, J.; DRORI, S.; ULDRY, M.; SILVAGGI, J.M.; RHEE, J.; JAGER, S.; HANDSCHIN, C.; ZHENG, K.; LIN, J.; YANG, W.: "Suppression of reactive oxygen species and neurodegeneration by the PGC-1 transcriptional coactivators", CELL, vol. 127, 2006, pages 397 - 408
VALLE, I.; ALVAREZ-BARRIENTOS, A.; ARZA, E.; LAMAS, S.; MONSALVE, M.: "PGC-lalpha regulates the mitochondrial antioxidant defense system in vascular endothelial cells", CARDIOVASC. RES., vol. 66, 2005, pages 562 - 573
XIONG, S.; PATRUSHEV N.; FOROUUZANDEH, F.; HILENSKI, L.; ALEXANDER, R.W.: "PGC-1a modulates telomere function and DNA damage inprotecting against age-related chronic diseases", CELL REPORT, vol. 12, 2015, pages 1391 - 1399
BORNIQUEL, S.; VALLE, I.; CADENAS, S.; LAMAS, S.; MONSALVE, M.: "Nitric oxide regulates mitochondrial oxidative stress protection via the transcriptional coactivator PGC-lalpha", THE FASEB JOURNAL: OFFICIAL PUBLICATION OF THE FEDERATION OF AMERICAN SOCIETIES FOR EXPERIMENTAL BIOLOGY, vol. 20, 2006, pages 1889 - 1891
LAI, L.; LEONE, T.C.; ZECHNER, C.; SCHAEFFER, P.J.; KELLY, S.M.; FLANAGAN, D.P.; MEDEIROS, D.M.; KOVACS, A.; KELLY, D.P.: "Transcriptional coactivators PGC-lalpha and PGC-lbeta control overlapping programs required for perinatal maturation of the heart", GENES DEV., vol. 22, 2008, pages 1948 - 1961
GARNIER, A.; FORTIN, D.; DELOMENIE, C.; MOMKEN, I.; VEKSLER, V.; VENTURA-CLAPIER, R.: "Depressed mitochondrial transcription factors and oxidative oxidative capacity in rat failing cardiac and skeletal muscles", J. PHYSIOL., vol. 551, 2003, pages 491 - 501, XP008042859, DOI: doi:10.1113/jphysiol.2003.045104
LJUBICIC V; JOSEPH A; SALEEM A ET AL.: "Transcriptional and post-transcriptional regulation of mitochondrial biogenesis in skeletal muscle: effects of exercise and aging", BIOCHIM BIOPHYS ACTA, vol. 1800, 2010, pages 223 - 234, XP026911631, DOI: doi:10.1016/j.bbagen.2009.07.031
GOUSPILLOU G; PICARD M; GODIN R; BURELLE Y; HEPPLE R: "Role of peroxisome proliferative activated receptor gamma coactivator 1-alpha (PGC-la) in denervation-induced atrophy in aged muscle: facts and hypotheses", LONGEV HEALTHSPAN, vol. 2, 2013, pages 13
JOHNSON ML; ROBINSON MM; NAIR KS: "Skeletal muscle aging and the mitochondrion", TRENDS ENDOCRIN MET, vol. 24, 2013, pages 247 - 256
MARZETTI E; CALVANI R; CESARI M ET AL.: "Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials", INT J BIOCHEM CELL BIOL, vol. 45, 2013, pages 2288 - 2301, XP028699825, DOI: doi:10.1016/j.biocel.2013.06.024
CALVANI R; JOSEPH A; ADHIHETTY PJ ET AL.: "Mitochondrial pathways in sarcopenia of aging and disuse muscle atrophy", BIOL CHEM, vol. 394, 2013, pages 393 - 414
WALLACE DC: "A mitochondrial paradigm of metabolic and degenerative diseases, aging, and cancer: a dawn for evolutionary medicine", ANNU REV GENET, vol. 39, 2005, pages 359, XP055169259, DOI: doi:10.1146/annurev.genet.39.110304.095751
FINCK BN; KELLY DP: "PGC-1 coactivators: inducible regulators of energy metabolism in health and disease", J CLIN INVEST, vol. 116, 2006, pages 615 - 622
TINA WENZ; SUSANA G. ROSSI; RICHARD L. ROTUNDO; BRUCE M. SPIEGELMAN; CARLOS T. MORAES: "Increased muscle PGC-1a expression protects from sarcopenia and metabolic disease during aging", PNAS, vol. 106, 2009, pages 20405 - 20410
ROLFE, D. F.; BROWN, G. C.: "Cellular energy utilization and molecular origin of standard metabolic rate in mammals", PHYSIOL. REV., vol. 77, 1997, pages 731 - 758, XP008022700
JASTROCH, M.; DIVAKARUNI, A. S.; MOOKERJEE, S.; TREBERG, J. R.; BRAND, M. D.: "Mitochondrial proton and electron leaks", ESSAYS BIOCHEM., vol. 47, 2010, pages 53 - 67
FUKUI Y; MASUI S; OSADA S; UMESONO K; MOTOJIMA K: "A new thiazolidinedione, NC-2100, which is a weak PPAR-g activator, exhibits potent antidiabetic effects and induces uncoupling protein 1 in white adipose tissue of KKAy obese mice", DIABETES, vol. 49, 2000, pages 759 - 767, XP002990563, DOI: doi:10.2337/diabetes.49.5.759
WILSON-FRITCH L; NICOLORO S; CHOUINARD M; LAZAR MA; CHUI PC; LESZYK J; STRAUBHAAR J; CZECH MP; CORVERA S: "Mitochondrial remodeling in adipose tissue associated with obesity and treatment with rosiglitazone", J CLIN INVEST, vol. 114, 2004, pages 1281 - 1289, XP002505380, DOI: doi:10.1172/JCI200421752
QUINLAN, C. L.; TREBERG, J. R.; BRAND, M. D.: "Handbook of the Biology of Aging", 2011, ACADEMIC PRESS, article "Mechanisms of mitochondrial free radical production and their relationship to the aging process", pages: 47 - 61
SAHIN, E.; COLLA, S.; LIESA, M.; MOSLEHI, J.; MU''LLER, F. L.; GUO, M.; COOPER, M.; KOTTON, D.; FABIAN, A. J.; WALKEY, C. ET AL.: "Telomere dysfunction induces metabolic and mitochondrial compromise", NATURE, vol. 470, 2011, pages 359 - 365
KUJOTH, G. C.; HIONA, A.; PUGH, T. D.; SOMEYA, S.; PANZER, K.; WOHLGEMUTH, S. E.; HOFER, T.; SEO, A. Y.; SULLIVAN, R.; JOBLING, W.: "Mitochondrial DNA mutations, oxidative stress, and apoptosis in mammalian aging", SCIENCE, vol. 309, 2005, pages 481 - 484
TRIFUNOVIC, A.; WREDENBERG, A.; FALKENBERG, M.; SPELBRINK, J. N.; ROVIO, A. T.; BRUDER, C. E.; BOHLOOLY-Y, M.; GIDLO''F, S.; OLDFO: "Premature ageing in mice expressing defective mitochondrial DNA polymerase", NATURE, vol. 429, 2004, pages 417 - 423
LIN, J.; WU, H.; TARR, P. T.; ZHANG, C. Y.; WU, Z.; BOSS, 0.; MICHAEL, L. F.; PUIGSERVER, P.; ISOTANI, E.; OLSON, E. N. ET AL.: "Transcriptional co-activator PGC-1 alpha drives the formation of slow-twitch muscle fibres", NATURE, vol. 418, 2002, pages 797 - 801, XP002345819, DOI: doi:10.1038/nature00904
DILLON, L. M.; WILLIAMS, S. L.; HIDA, A.; PEACOCK, J. D.; PROLLA, T. A.; LINCOLN, J.; MORAES, C. T.: "Increased mitochondrial biogenesis in muscle improves aging phenotypes in the mtDNA mutator mouse", HUM. MOL. GENET., vol. 21, 2012, pages 2288 - 2297
WENZ, T.; ROSSI, S. G.; ROTUNDO, R. L.; SPIEGELMAN, B. M.; MORAES, C. T.: "Increased muscle PGC-lalpha expression protects from sarcopenia and metabolic disease during aging", PROC. NATL. ACAD. SCI. USA, vol. 106, 2009, pages 20405 - 20410
See also references of EP 3403655A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
Download PDF: