Title:
COMPOSITION FOR INCREASING RED BLOOD CELLS AND/OR HEMOGLOBIN
Document Type and Number:
WIPO Patent Application WO/2022/230487
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide: a composition for increasing red blood cells and/or hemoglobin; a composition for preventing or ameliorating anemia; a composition for improving endurance; an anti-fatigue composition; a method for increasing red blood cells and/or hemoglobin; a method for preventing or ameliorating anemia; a method for improving endurance; and a method for ameliorating, relieving, recovering or preventing fatigue. The present invention relates to a composition for increasing red blood cells and/or hemoglobin, the composition containing L-ergothioneine or a salt thereof as an active ingredient.
Inventors:
KATSUBE MAKOTO (JP)
WATANABE HIROSHI (JP)
MURAYAMA NORIHITO (JP)
WATANABE HIROSHI (JP)
MURAYAMA NORIHITO (JP)
Application Number:
PCT/JP2022/014221
Publication Date:
November 03, 2022
Filing Date:
March 25, 2022
Export Citation:
Assignee:
SUNTORY HOLDINGS LTD (JP)
International Classes:
A61K31/4172; A23L33/175; A61P3/00; A61P3/02; A61P7/00; A61P7/06; A61P43/00
Domestic Patent References:
| WO2012174035A2 | 2012-12-20 | |||
| WO2020004014A1 | 2020-01-02 |
Foreign References:
| JP2011102286A | 2011-05-26 |
Other References:
CHAVES NAYARA ALVES; ALEGRIA THIAGO GERONIMO PIRES; DANTAS LUCAS SOUZA; NETTO LUIS EDUARDO SOARES; MIYAMOTO SAYURI; BONINI DOMINGO: "Impaired antioxidant capacity causes a disruption of metabolic homeostasis in sickle erythrocytes", FREE RADICAL BIOLOGY & MEDICINE, ELSEVIER INC, US, vol. 141, 1 June 2019 (2019-06-01), US , pages 34 - 46, XP085771082, ISSN: 0891-5849, DOI: 10.1016/j.freeradbiomed.2019.05.034
ARDUINI, A. ; MANCINELLI, G. ; RADATTI, G.L. ; HOCHSTEIN, P. ; CADENAS, E.: "Possible mechanism of inhibition of nitrite-induced oxidation of oxyhemoglobin by ergothioneine and uric acid", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 294, no. 2, 1 May 1992 (1992-05-01), US , pages 398 - 402, XP024762290, ISSN: 0003-9861, DOI: 10.1016/0003-9861(92)90702-X
MOMMA REIKO, KUMAGAI HIROSHI, OSHIDEN MOE, IEMITSU MOTOYUKI, MAEDA SEIJI: "Relationship between anemia and circulating levels of amino acids in female endurance athletes", TAIRYOKU KAGAKU, NIHON TAIRYOKU IGAKKAI, TOKYO, JP, vol. 66, no. 6, 1 January 2017 (2017-01-01), JP , pages 391 - 397, XP055980454, ISSN: 0039-906X, DOI: 10.7600/jspfsm.66.391
TOSHIMICHI NAKAMURA ; SHIGEKI SUGIURA ; DAISUKE KOBAYASHI ; KENJI YOSHIDA ; HIKARU YABUUCHI ; SHIN AIZAWA ; TOMOJI MAEDA ; IKUMI T: "Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 24, no. 9, 20 April 2007 (2007-04-20), NL , pages 1628 - 1635, XP019532555, ISSN: 1573-904X, DOI: 10.1007/s11095-007-9290-8
KAMEDA MASAHIRO, TAKAYUKI TERUYA, MITSUHIRO YANAGIDA, HIROSHI KONDOH: "Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility", PROC NATL ACAD SCI., vol. 117, no. 17, 15 April 2020 (2020-04-15), pages 9483 - 9489, XP055980460, DOI: 10.1073/pnas.1920795117
WATANABE, NORIKAZU ET AL.: "Effect of Ergothioneine on the Cognitive Function Improvement in Healthy Volunteers and Mild Cognitive Impairment Subjects- A Randomized, Double-blind, Parallel-group Comparison Study-", JAPANESE PHARMACOLOGY AND THERAPEUTICS, RAIFU SAIENSU SHUPPAN, TOKYO., JP, vol. 48, no. 4, 1 January 2020 (2020-01-01), JP , pages 685 - 697, XP009540733, ISSN: 0386-3603
IRWIN K. CHEAH, RICHARD M.Y. TANG, TERRY S.Z. YEW, KEITH H.C. LIM, BARRY HALLIWELL: "Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation", ANTIOXIDANTS AND REDOX SIGNALING, MARY ANN LIEBERT, LARCHMONT, NY, US, vol. 26, no. 5, 10 February 2017 (2017-02-10), US , pages 193 - 206, XP055654322, ISSN: 1523-0864, DOI: 10.1089/ars.2016.6778
TURCK DOMINIQUE, BRESSON JEAN‐LOUIS, BURLINGAME BARBARA, DEAN TARA, FAIRWEATHER‐TAIT SUSAN, HEINONEN MARINA, HIRSCH‐ERNST KAREN IL: "Safety of synthetic l‐ergothioneine (Ergoneine®) as a novel food pursuant to Regulation (EC) No 258/97", THE EFSA JOURNAL, EUROPEAN FOOD SAFETY AUTHORITY (E F S A), PARMA, IT, vol. 14, no. 11, 1 November 2016 (2016-11-01), Parma, IT , XP055980463, ISSN: 1831-4732, DOI: 10.2903/j.efsa.2016.4629
MARONE PALMA ANN, TRAMPOTA JAN, WEISMAN STEVEN: "A Safety Evaluation of a Nature-Identical L-Ergothioneine in Sprague Dawley Rats", INTERNATIONAL JOURNAL OF TOXICOLOGY, SAGE PUBLICATIONS, INC., US, vol. 35, no. 5, 15 June 2016 (2016-06-15), US , pages 568 - 583, XP055980466, ISSN: 1091-5818, DOI: 10.1177/1091581816653375
ARDUINI, A. ; MANCINELLI, G. ; RADATTI, G.L. ; HOCHSTEIN, P. ; CADENAS, E.: "Possible mechanism of inhibition of nitrite-induced oxidation of oxyhemoglobin by ergothioneine and uric acid", ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS, ACADEMIC PRESS, US, vol. 294, no. 2, 1 May 1992 (1992-05-01), US , pages 398 - 402, XP024762290, ISSN: 0003-9861, DOI: 10.1016/0003-9861(92)90702-X
MOMMA REIKO, KUMAGAI HIROSHI, OSHIDEN MOE, IEMITSU MOTOYUKI, MAEDA SEIJI: "Relationship between anemia and circulating levels of amino acids in female endurance athletes", TAIRYOKU KAGAKU, NIHON TAIRYOKU IGAKKAI, TOKYO, JP, vol. 66, no. 6, 1 January 2017 (2017-01-01), JP , pages 391 - 397, XP055980454, ISSN: 0039-906X, DOI: 10.7600/jspfsm.66.391
TOSHIMICHI NAKAMURA ; SHIGEKI SUGIURA ; DAISUKE KOBAYASHI ; KENJI YOSHIDA ; HIKARU YABUUCHI ; SHIN AIZAWA ; TOMOJI MAEDA ; IKUMI T: "Decreased Proliferation and Erythroid Differentiation of K562 Cells by siRNA-induced Depression of OCTN1 (SLC22A4) Transporter Gene", PHARMACEUTICAL RESEARCH, KLUWER ACADEMIC PUBLISHERS-PLENUM PUBLISHERS, NL, vol. 24, no. 9, 20 April 2007 (2007-04-20), NL , pages 1628 - 1635, XP019532555, ISSN: 1573-904X, DOI: 10.1007/s11095-007-9290-8
KAMEDA MASAHIRO, TAKAYUKI TERUYA, MITSUHIRO YANAGIDA, HIROSHI KONDOH: "Frailty markers comprise blood metabolites involved in antioxidation, cognition, and mobility", PROC NATL ACAD SCI., vol. 117, no. 17, 15 April 2020 (2020-04-15), pages 9483 - 9489, XP055980460, DOI: 10.1073/pnas.1920795117
WATANABE, NORIKAZU ET AL.: "Effect of Ergothioneine on the Cognitive Function Improvement in Healthy Volunteers and Mild Cognitive Impairment Subjects- A Randomized, Double-blind, Parallel-group Comparison Study-", JAPANESE PHARMACOLOGY AND THERAPEUTICS, RAIFU SAIENSU SHUPPAN, TOKYO., JP, vol. 48, no. 4, 1 January 2020 (2020-01-01), JP , pages 685 - 697, XP009540733, ISSN: 0386-3603
IRWIN K. CHEAH, RICHARD M.Y. TANG, TERRY S.Z. YEW, KEITH H.C. LIM, BARRY HALLIWELL: "Administration of Pure Ergothioneine to Healthy Human Subjects: Uptake, Metabolism, and Effects on Biomarkers of Oxidative Damage and Inflammation", ANTIOXIDANTS AND REDOX SIGNALING, MARY ANN LIEBERT, LARCHMONT, NY, US, vol. 26, no. 5, 10 February 2017 (2017-02-10), US , pages 193 - 206, XP055654322, ISSN: 1523-0864, DOI: 10.1089/ars.2016.6778
TURCK DOMINIQUE, BRESSON JEAN‐LOUIS, BURLINGAME BARBARA, DEAN TARA, FAIRWEATHER‐TAIT SUSAN, HEINONEN MARINA, HIRSCH‐ERNST KAREN IL: "Safety of synthetic l‐ergothioneine (Ergoneine®) as a novel food pursuant to Regulation (EC) No 258/97", THE EFSA JOURNAL, EUROPEAN FOOD SAFETY AUTHORITY (E F S A), PARMA, IT, vol. 14, no. 11, 1 November 2016 (2016-11-01), Parma, IT , XP055980463, ISSN: 1831-4732, DOI: 10.2903/j.efsa.2016.4629
MARONE PALMA ANN, TRAMPOTA JAN, WEISMAN STEVEN: "A Safety Evaluation of a Nature-Identical L-Ergothioneine in Sprague Dawley Rats", INTERNATIONAL JOURNAL OF TOXICOLOGY, SAGE PUBLICATIONS, INC., US, vol. 35, no. 5, 15 June 2016 (2016-06-15), US , pages 568 - 583, XP055980466, ISSN: 1091-5818, DOI: 10.1177/1091581816653375
Attorney, Agent or Firm:
WISEPLUS IP FIRM (JP)
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