Title:
COMPOSITION FOR INDUCING BROWNING, CONTAINING MILK EXOSOMES
Document Type and Number:
WIPO Patent Application WO/2022/045668
Kind Code:
A1
Abstract:
The present invention relates to a composition for inducing browning, a pharmaceutical composition for preventing or treating metabolic diseases, and a food composition for alleviating metabolic diseases, all of the compositions containing milk exosomes. In addition, the present invention relates to a method for inducing the differentiation of white adipocytes into beige adipocytes or brown adipocytes by treating the milk exosomes, and a method for treating obesity or metabolic diseases by administering the milk exosomes.
Inventors:
KIM SANG HOON (KR)
BAE INSEON (KR)
BAE INSEON (KR)
Application Number:
PCT/KR2021/010968
Publication Date:
March 03, 2022
Filing Date:
August 18, 2021
Export Citation:
Assignee:
UNIV INDUSTRY COOPERATION GROUP KYUNG HEE UNIV (KR)
International Classes:
A61K35/20; A23L33/10; A61K31/7105; A61P1/16; A61P3/00; A61P3/04; A61P9/10; C12N5/077
Foreign References:
| JP6349405B2 | 2018-06-27 | |||
| US20190374467A1 | 2019-12-12 |
Other References:
BAE IN-SUN: "The roles of milk exosomes and exosome-derived microRNAs in anti-melanogenesis and anti-obesity", THESIS, DEPARTMENT OF BIOLOGY GRADUATE SCHOOL, KYUNG HEE UNIVERSITY, 20 August 2020 (2020-08-20), XP055904139, Retrieved from the Internet
DATABASE NUCLEOTIDE 5 July 2020 (2020-07-05), ANONYMOUS : "Bos taurus microRNA mir-11980 (MIR11980), microRNA ", XP055904142, retrieved from NCBI Database accession no. NR_162263
MELNIK BODO C., SCHMITZ GERD: "Exosomes of pasteurized milk: potential pathogens of Western diseases", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 17, no. 1, 1 December 2019 (2019-12-01), XP055773012, DOI: 10.1186/s12967-018-1760-8
ZHOU XUEYING, LI ZHELONG, QI MEIHAO, ZHAO PING, DUAN YUNYOU, YANG GUODONG, YUAN LIJUN: "Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 10, no. 18, 1 January 2020 (2020-01-01), AU , pages 8197 - 8210, XP055904143, ISSN: 1838-7640, DOI: 10.7150/thno.43968
See also references of EP 4082553A4
DATABASE NUCLEOTIDE 5 July 2020 (2020-07-05), ANONYMOUS : "Bos taurus microRNA mir-11980 (MIR11980), microRNA ", XP055904142, retrieved from NCBI Database accession no. NR_162263
MELNIK BODO C., SCHMITZ GERD: "Exosomes of pasteurized milk: potential pathogens of Western diseases", JOURNAL OF TRANSLATIONAL MEDICINE, vol. 17, no. 1, 1 December 2019 (2019-12-01), XP055773012, DOI: 10.1186/s12967-018-1760-8
ZHOU XUEYING, LI ZHELONG, QI MEIHAO, ZHAO PING, DUAN YUNYOU, YANG GUODONG, YUAN LIJUN: "Brown adipose tissue-derived exosomes mitigate the metabolic syndrome in high fat diet mice", THERANOSTICS, IVYSPRING INTERNATIONAL PUBLISHER, AU, vol. 10, no. 18, 1 January 2020 (2020-01-01), AU , pages 8197 - 8210, XP055904143, ISSN: 1838-7640, DOI: 10.7150/thno.43968
See also references of EP 4082553A4
Attorney, Agent or Firm:
HANA IP LAW FIRM (KR)
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