COMPOSITION FOR INDUCING OR ENHANCING GENERATION OF CONES OR CONE-LIKE RODS

WIPO Patent Application WO/2022/124760

A1

Provided is a composition for inducing or enhancing the generation of cones or cone-like rods, the composition comprising an asymmetric RNAi-inducing nucleic acid molecule to inhibit the expression of the neural retina leucine zipper (NRL) gene.

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JPH0622787	HUMAN METABOTROPIC GLUTAMATE RECEPTOR AND RELATED DNA COMPOUND

CHUNG HYE WON (KR)
CHAE JAE BYOUG (KR)
JANG HYO IK (KR)

PCT/KR2021/018460

June 16, 2022

December 07, 2021

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OLIX PHARMACEUTICALS INC (KR)
KONKUK UNIV GLOCAL IND ACADEMIC COLLABORATION FOUND (KR)

C12N5/079; C12N15/113

WO2020154693A1

2020-07-30

KR20200090132A	2020-07-28
KR20140046339A	2014-04-18

WENHAN YU, SUDDHASIL MOOKHERJEE, VIJENDER CHAITANKAR, SUJA HIRIYANNA, JUNG-WOONG KIM, MATTHEW BROOKS, YASAMAN ATAEIJANNATI, XUN SU: "Nrl knockdown by AAV-delivered CRISPR/Cas9 prevents retinal degeneration in mice", NATURE COMMUNICATIONS, vol. 8, 1 January 2017 (2017-01-01), pages 1 - 15, XP055479667, DOI: 10.1038/ncomms14716
MOORE SPENCER M., SKOWRONSKA-KRAWCZYK DOROTA, CHAO DANIEL L.: "Targeting of the NRL Pathway as a Therapeutic Strategy to Treat Retinitis Pigmentosa", JOURNAL OF CLINICAL MEDICINE, vol. 9, no. 7, 1 January 2020 (2020-01-01), pages 1 - 18, XP055941958, DOI: 10.3390/jcm9072224

Y.P.LEE, MOCK & PARTNERS (KR)

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