Title:
COMPOSITION FOR INHIBITING CANCER STEM CELL GROWTH COMPRISING PRIMAQUINE
Document Type and Number:
WIPO Patent Application WO/2018/048008
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting cancer stem cell growth comprising primaquine or a pharmaceutically acceptable salt thereof as an active ingredient, and to a pharmaceutical composition, a food composition and so forth, comprising the composition, for cancer metastasis inhibition or cancer treatment or prevention. The primaquine according to the present invention inhibits the growth of breast cancer cells and the formation of breast cancer stem cells. Also, the primaquine inhibited the expression of self-renewal genes, such as Nanog, C-Myc, Oct4, Sox2, Snail and CD44, which are known to be expressed typically in breast cancer stem cells, and it has been confirmed that signal transducer STAT3 is involved therein. Accordingly, the primaquine inhibits breast cancer and breast cancer stem cell growth and can be used for treating cancer such as breast cancer.
Inventors:
LEE DONG-SUN (KR)
KIM SULIM (KR)
CHOI HACK SUN (KR)
KIM JIHYANG (KR)
KO YUCHAN (KR)
KIM SULIM (KR)
CHOI HACK SUN (KR)
KIM JIHYANG (KR)
KO YUCHAN (KR)
Application Number:
PCT/KR2016/010829
Publication Date:
March 15, 2018
Filing Date:
September 27, 2016
Export Citation:
Assignee:
JEJU NATIONAL UNIV INDUSTRY ACADEMIC COOPERATION FOUNDATION (KR)
International Classes:
A61K31/4706; A23L33/10
Foreign References:
| US7632678B2 | 2009-12-15 | |||
| KR20150136001A | 2015-12-04 | |||
| KR20150088589A | 2015-08-03 | |||
| KR20160026624A | 2016-03-09 | |||
| JP2016504402A | 2016-02-12 |
Attorney, Agent or Firm:
KIM, Jin Dong (KR)
Download PDF: