Title:
COMPOSITION FOR INHIBITING EXPRESSION OF ANGIOTENSIN CONVERTING ENZYME 2 (ACE2) AND/OR TMPRSS2
Document Type and Number:
WIPO Patent Application WO/2022/163852
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition for inhibiting the expression of angiotensin converting enzyme 2 (ACE2) and/or TMPRSS2. Provided is a composition for inhibiting the expression of angiotensin converting enzyme 2 (ACE2) and/or TMPRSS2, the composition containing a FoxO1 inhibitor.
Inventors:
URUSHIHATA NAOKI (JP)
OKI KATSUYUKI (JP)
YOSHIHARA SEIICHI (JP)
ONISHI KEISUKE (JP)
OKI KATSUYUKI (JP)
YOSHIHARA SEIICHI (JP)
ONISHI KEISUKE (JP)
Application Number:
PCT/JP2022/003677
Publication Date:
August 04, 2022
Filing Date:
January 31, 2022
Export Citation:
Assignee:
BIOMIMETICS SYMPATHIES INC (JP)
International Classes:
A61K45/00; A61K31/47; A61K31/4706; A61K38/18; A61K38/28; A61K48/00; A61P5/48; A61P31/14; A61P43/00; C07K14/475; C07K14/485; C07K14/50; C07K14/62; C07K14/65; C12N15/09; C12N15/16
Domestic Patent References:
| WO2015095650A1 | 2015-06-25 | |||
| WO2020169707A1 | 2020-08-27 |
Foreign References:
| JP2016065055A | 2016-04-28 | |||
| JP6906127B1 | 2021-07-21 | |||
| JP6953047B1 | 2021-10-27 |
Other References:
COUSELO‐SEIJAS MARINELA, ALMENGLÓ CRISTINA, AGRA‐BERMEJO ROSA, FERNANDEZ ÁNGEL, ALVAREZ EZEQUIEL, GONZÁLEZ‐JUANATEY JOSE, EIRAS SO: "Higher ACE2 expression levels in epicardial cells than subcutaneous stromal cells from patients with cardiovascular disease: Diabetes and obesity as possible enhancer", EUROPEAN JOURNAL OF CLINICAL INVESTIGATION, WILEY-BLACKWELL PUBLISHING LTD., GB, vol. 51, no. 5, 14 May 2021 (2021-05-14), GB , XP055955435, ISSN: 0014-2972, DOI: 10.1111/eci.13463
SALEM ESAM S. B., GROBE NADJA, ELASED KHALID M.: "Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice", AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, UNITED STATES, vol. 306, no. 6, 15 March 2014 (2014-03-15), United States , pages F629 - F639, XP055955437, ISSN: 1931-857X, DOI: 10.1152/ajprenal.00516.2013
KALBHANDE DR JAYESH G, KALBHANDE G, DR VICKY, KULDEEP: "Use of Insulin in treatment of COVID-19: A proposal to explore feasibility", JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH, vol. 08, no. 07, 31 July 2020 (2020-07-31), XP055955440, DOI: 10.18535/jmscr/v8i7.103
MISHRA DEVANSHI, DEY CHINMOY SANKAR: "Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter?", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 49, no. 2, 30 April 2021 (2021-04-30), GB , pages 987 - 995, XP009538677, ISSN: 0300-5127, DOI: 10.1042/BST20201062
FAN XIKANG; YIN CHENG; WANG JIAYU; YANG MINGJIA; MA HONGXIA; JIN GUANGFU; SONG MINGYANG; HU ZHIBIN; SHEN HONGBING; HANG DONG: "Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank", EUROPEAN JOURNAL OF EPIDEMIOLOGY, SPRINGER NETHERLANDS, DORDRECHT, vol. 36, no. 3, 1 January 1900 (1900-01-01), Dordrecht, pages 311 - 318, XP037418366, ISSN: 0393-2990, DOI: 10.1007/s10654-020-00709-1
ESQUIVEL DIANA; MISHRA RANGNATH; SONI PRABHAT; SEETHARAMAN RAJASEKAR; MAHMOOD ANJUM; SRIVASTAVA ANAND: "Stem Cells Therapy as a Possible Therapeutic Option in Treating COVID-19 Patients", STEM CELL REVIEWS AND REPORTS, SPRINGER US, NEW YORK, vol. 17, no. 1, 1 January 1900 (1900-01-01), New York , pages 144 - 152, XP037374875, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10017-6
POCSFALVI GABRIELLA, MAMMADOVA RAMILA, RAMOS JUAREZ ANA PAULINA, BOKKA RAMESH, TREPICCIONE FRANCESCO, CAPASSO GIOVAMBATT: "COVID-19 and Extracellular Vesicles: An Intriguing Interplay", KIDNEY AND BLOOD PRESSURE RESEARCH, BASEL, CH, vol. 45, no. 5, 1 October 2020 (2020-10-01), CH , pages 661 - 670, XP055826579, ISSN: 1420-4096, DOI: 10.1159/000511402
ROCHA JOSé LUCAS MARTINS; DE OLIVEIRA WALDIR CéSAR FERREIRA; NORONHA NáDIA CáSSIA; DOS SANTOS NATALIA CRISTINE: "Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19", STEM CELL REVIEWS AND REPORTS, SPRINGER US, NEW YORK, vol. 17, no. 1, 1 January 1900 (1900-01-01), New York , pages 71 - 93, XP037374869, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10032-7
PEDERSEN KIM BRINT, CHODAVARAPU HARSHITA, LAZARTIGUES ERIC: "Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2", JOURNAL OF THE ENDOCRINE SOCIETY, vol. 1, no. 4, 1 April 2017 (2017-04-01), pages 370 - 384, XP055955447, DOI: 10.1210/js.2016-1071
JHA PRABHASH KUMAR, VIJAY AATIRA, HALU ARDA, UCHIDA SHIZUKA, AIKAWA MASANORI: "Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 7, 15 January 2021 (2021-01-15), XP055955452, DOI: 10.3389/fcvm.2020.623012
ALSAMMAN, A. M: "The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1", PLOS ONE, 1 May 2020 (2020-05-01), pages 1 - 30, XP055955453, Retrieved from the Internet [retrieved on 20220826], DOI: 2020.05.06.080960
SALEM ESAM S. B., GROBE NADJA, ELASED KHALID M.: "Insulin treatment attenuates renal ADAM17 and ACE2 shedding in diabetic Akita mice", AMERICAN JOURNAL OF PHYSIOLOGY: RENAL PHYSIOLOGY, AMERICAN PHYSIOLOGICAL SOCIETY, UNITED STATES, vol. 306, no. 6, 15 March 2014 (2014-03-15), United States , pages F629 - F639, XP055955437, ISSN: 1931-857X, DOI: 10.1152/ajprenal.00516.2013
KALBHANDE DR JAYESH G, KALBHANDE G, DR VICKY, KULDEEP: "Use of Insulin in treatment of COVID-19: A proposal to explore feasibility", JOURNAL OF MEDICAL SCIENCE AND CLINICAL RESEARCH, vol. 08, no. 07, 31 July 2020 (2020-07-31), XP055955440, DOI: 10.18535/jmscr/v8i7.103
MISHRA DEVANSHI, DEY CHINMOY SANKAR: "Type-2 diabetes, a co-morbidity in Covid-19: does insulin signaling matter?", BIOCHEMICAL SOCIETY TRANSACTIONS, PORTLAND PRESS LTD, GB, vol. 49, no. 2, 30 April 2021 (2021-04-30), GB , pages 987 - 995, XP009538677, ISSN: 0300-5127, DOI: 10.1042/BST20201062
FAN XIKANG; YIN CHENG; WANG JIAYU; YANG MINGJIA; MA HONGXIA; JIN GUANGFU; SONG MINGYANG; HU ZHIBIN; SHEN HONGBING; HANG DONG: "Pre-diagnostic circulating concentrations of insulin-like growth factor-1 and risk of COVID-19 mortality: results from UK Biobank", EUROPEAN JOURNAL OF EPIDEMIOLOGY, SPRINGER NETHERLANDS, DORDRECHT, vol. 36, no. 3, 1 January 1900 (1900-01-01), Dordrecht, pages 311 - 318, XP037418366, ISSN: 0393-2990, DOI: 10.1007/s10654-020-00709-1
ESQUIVEL DIANA; MISHRA RANGNATH; SONI PRABHAT; SEETHARAMAN RAJASEKAR; MAHMOOD ANJUM; SRIVASTAVA ANAND: "Stem Cells Therapy as a Possible Therapeutic Option in Treating COVID-19 Patients", STEM CELL REVIEWS AND REPORTS, SPRINGER US, NEW YORK, vol. 17, no. 1, 1 January 1900 (1900-01-01), New York , pages 144 - 152, XP037374875, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10017-6
POCSFALVI GABRIELLA, MAMMADOVA RAMILA, RAMOS JUAREZ ANA PAULINA, BOKKA RAMESH, TREPICCIONE FRANCESCO, CAPASSO GIOVAMBATT: "COVID-19 and Extracellular Vesicles: An Intriguing Interplay", KIDNEY AND BLOOD PRESSURE RESEARCH, BASEL, CH, vol. 45, no. 5, 1 October 2020 (2020-10-01), CH , pages 661 - 670, XP055826579, ISSN: 1420-4096, DOI: 10.1159/000511402
ROCHA JOSé LUCAS MARTINS; DE OLIVEIRA WALDIR CéSAR FERREIRA; NORONHA NáDIA CáSSIA; DOS SANTOS NATALIA CRISTINE: "Mesenchymal Stromal Cells in Viral Infections: Implications for COVID-19", STEM CELL REVIEWS AND REPORTS, SPRINGER US, NEW YORK, vol. 17, no. 1, 1 January 1900 (1900-01-01), New York , pages 71 - 93, XP037374869, ISSN: 2629-3269, DOI: 10.1007/s12015-020-10032-7
PEDERSEN KIM BRINT, CHODAVARAPU HARSHITA, LAZARTIGUES ERIC: "Forkhead Box Transcription Factors of the FOXA Class Are Required for Basal Transcription of Angiotensin-Converting Enzyme 2", JOURNAL OF THE ENDOCRINE SOCIETY, vol. 1, no. 4, 1 April 2017 (2017-04-01), pages 370 - 384, XP055955447, DOI: 10.1210/js.2016-1071
JHA PRABHASH KUMAR, VIJAY AATIRA, HALU ARDA, UCHIDA SHIZUKA, AIKAWA MASANORI: "Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19", FRONTIERS IN CARDIOVASCULAR MEDICINE, vol. 7, 15 January 2021 (2021-01-15), XP055955452, DOI: 10.3389/fcvm.2020.623012
ALSAMMAN, A. M: "The transcriptomic profiling of SARS-CoV-2 compared to SARS, MERS, EBOV, and H1N1", PLOS ONE, 1 May 2020 (2020-05-01), pages 1 - 30, XP055955453, Retrieved from the Internet
Attorney, Agent or Firm:
AXIS PATENT INTERNATIONAL (JP)
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