COMPOSITION FOR INHIBITING GROWTH OF BREAST CANCER STEM CELLS, COMPRISING PHENYLACETALDEHYDE - JEJU NAT UNIV INDUSTRY-ACADEMIC COOP FOUND

Title:

COMPOSITION FOR INHIBITING GROWTH OF BREAST CANCER STEM CELLS, COMPRISING PHENYLACETALDEHYDE

Document Type and Number:

WIPO Patent Application WO/2017/188690

Kind Code:

A1

Abstract:

The present invention relates to a composition for inhibiting the growth of breast cancer stem cells, which comprises phenylacetaldehyde or a pharmaceutically acceptable salt thereof as an active ingredient, an aromatic composition, a pharmaceutical composition for inhibiting the metastasis of breast cancer or treating or preventing breast cancer, which comprises said composition, and a food composition. Phenylacetaldehyde according to the present invention inhibits the growth of breast cancer cells and inhibits the formation of breast cancer stem cells. Further, phenylacetaldehyde according to the present invention has inhibited the expression of self-renewal genes, such as Nanog, Sox2, Oct4, and CD44, known to be characteristically expressed in breast cancer stem cells, has inhibited the production of IL-6 known to be involved in the mammosphere formation of breast cancer stem cells, and has been confirmed to inhibit an STAT3 signaling pathway. Accordingly, said compound inhibits the growth of breast cancer stem cells and can be utilized in the treatment of breast cancer.

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Inventors:

LEE DONG SUN (KR)
CHOI HACK SUN (KR)
JUNG DONG KEE (KR)

Application Number:

PCT/KR2017/004356

Publication Date:

November 02, 2017

Filing Date:

April 25, 2017

Export Citation:

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Assignee:

JEJU NAT UNIV INDUSTRY-ACADEMIC COOP FOUND (KR)

International Classes:

A61K31/11; A23L33/10; A61K8/33; A61Q13/00; A61Q19/00; C07C47/228

Domestic Patent References:

WO2010059711A1

2010-05-27

Foreign References:

KR20150136001A	2015-12-04
KR101289033B1	2013-07-23
JP2013510143A	2013-03-21
KR101724541B1	2017-04-07

Other References:

ZHENG, Z.-P ET AL.: "A Phenylacetaldehyde-llavonoid Adduct, 8-C-(E-phenytethenyl)-norartocarpeti Exhibits intrinsic Apoptosis and MAPK Pathways-related Anticancer Potential on HepG2 SMMC-7721 and QGY-7703.", FOOD CHEMISTRY, vol. 197, 27 November 2015 (2015-11-27), pages 1085 - 1092, XP029348080

Attorney, Agent or Firm:

KIM, Jin Dong (KR)

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