Title:
COMPOSITION FOR INHIBITING MIGRATION OF ENDOTOXIN INTO BLOOD
Document Type and Number:
WIPO Patent Application WO/2017/126645
Kind Code:
A1
Abstract:
The purpose of the present invention is to provide a composition for inhibiting the migration of endotoxin into blood. According to the present invention, a composition for inhibiting the migration of endotoxin into blood is provided, which contains a whey protein. The whey protein can be selected from the group consisting of α-lactalbumin, β-lactoglobulin and lactoferrin. The composition according to the present invention may additionally contain a fermented milk protein.
Inventors:
KUME HISAE (JP)
OKAZAKI KEIKO (JP)
ASHIDA KINYA (JP)
OKAZAKI KEIKO (JP)
ASHIDA KINYA (JP)
Application Number:
PCT/JP2017/001856
Publication Date:
July 27, 2017
Filing Date:
January 20, 2017
Export Citation:
Assignee:
MEIJI CO LTD (JP)
International Classes:
A61K38/00; A61K31/202; A61K31/7016; A61K35/20; A61K38/16; A61P1/08; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P9/00; A61P9/04; A61P9/10; A61P13/12; A61P21/00; A61P25/20; A61P25/28; A61P29/00; A61P43/00
Domestic Patent References:
| WO2011065552A1 | 2011-06-03 | |||
| WO2013080911A1 | 2013-06-06 |
Foreign References:
| JPH05501416A | 1993-03-18 | |||
| JP2001333737A | 2001-12-04 | |||
| US20010014322A1 | 2001-08-16 | |||
| JPH07278013A | 1995-10-24 |
Other References:
KAORI KITAMURA ET AL.: "Intake of natural milk antibody reduces blood and feces endotoxin level", AMINO ACID RESEARCH, vol. 8, no. 1, 2014, pages 55 - 57
KEN'ICHI IKEJIMA ET AL.: "Chonai Saikin to Kan Shikkan", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 216, no. 4, 2006, pages 281 - 285
KAZUYOSHI YOSHIMURA ET AL.: "T PN ni yoru Nenmaku Ishuku to bacterial translocation", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE SHOKAKI SHIKKAN -STATE OF ARTS I, 1993, pages 75 - 77
YOSHIO SUMIDA ET AL.: "Role of gut microbiota in chronic liver diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 251, no. 1, 2014, pages 81 - 84
MAROTTA, F. ET AL.: "Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect", CHINESE JOURNAL OF DIGESTIVE DISEASES, vol. 6, 2005, pages 193 - 197, XP055400643
HISAE KUME ET AL.: "Whey Peptide Haigo Men'eki Chosei Ryudoshoku no ConA Yuhatsu Kan Shogai Yokusei Sayo eno Bacterial Translocation no Kan'yo", THE JOURNAL OF JAPANESE SOCIETY FOR PARENTERAL AND ENTERAL NUTRITION, vol. 31, no. 1, 27 February 2016 (2016-02-27), pages 421
HASHIMOTO, K. ET AL.: "Stabilization of the Tight Junction of the Intestinal Caco-2 Cell Monolayer by Milk Whey Proteins", BIOSCI. BIOTECH. BIOCHEM., vol. 59, no. 10, 1995, pages 1951 - 1952, XP055400651
KEN'ICHI IKEJIMA ET AL.: "Chonai Saikin to Kan Shikkan", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 216, no. 4, 2006, pages 281 - 285
KAZUYOSHI YOSHIMURA ET AL.: "T PN ni yoru Nenmaku Ishuku to bacterial translocation", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE SHOKAKI SHIKKAN -STATE OF ARTS I, 1993, pages 75 - 77
YOSHIO SUMIDA ET AL.: "Role of gut microbiota in chronic liver diseases", JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE, vol. 251, no. 1, 2014, pages 81 - 84
MAROTTA, F. ET AL.: "Experimental acute alcohol pancreatitis-related liver damage and endotoxemia: synbiotics but not metronidazole have a protective effect", CHINESE JOURNAL OF DIGESTIVE DISEASES, vol. 6, 2005, pages 193 - 197, XP055400643
HISAE KUME ET AL.: "Whey Peptide Haigo Men'eki Chosei Ryudoshoku no ConA Yuhatsu Kan Shogai Yokusei Sayo eno Bacterial Translocation no Kan'yo", THE JOURNAL OF JAPANESE SOCIETY FOR PARENTERAL AND ENTERAL NUTRITION, vol. 31, no. 1, 27 February 2016 (2016-02-27), pages 421
HASHIMOTO, K. ET AL.: "Stabilization of the Tight Junction of the Intestinal Caco-2 Cell Monolayer by Milk Whey Proteins", BIOSCI. BIOTECH. BIOCHEM., vol. 59, no. 10, 1995, pages 1951 - 1952, XP055400651
Attorney, Agent or Firm:
YOKOTA Nobutaka et al. (JP)
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