Title:
COMPOSITION FOR INHIBITING MYOSTATIN ACTIVITY, CONTAINING MATRIX gla PROTEIN AS ACTIVE INGREDIENT
Document Type and Number:
WIPO Patent Application WO/2018/135738
Kind Code:
A1
Abstract:
The present invention relates to a composition for inhibiting myostatin activity, containing a matrix gla protein as an active ingredient. More specifically, it is confirmed that a composition containing a matrix gla protein as an active ingredient promotes the differentiation of muscle satellite cells by increasing the expression of genes associated with the differentiation of the muscle and inhibits myostatin activity by inhibiting the binding of myostatin, which induces muscle wasting, with ACVRIIB, and thus the composition containing a matrix gla protein as an active ingredient can be effectively usable as an agent for modulating myostatin activity and an agent for treating muscle diseases such as myostatin-induced muscle wasting.
Inventors:
CHOI IN HO (KR)
LEE EUN JU (KR)
LEE EUN JU (KR)
Application Number:
PCT/KR2017/013190
Publication Date:
July 26, 2018
Filing Date:
November 20, 2017
Export Citation:
Assignee:
UNIV YEUNGNAM RES COOPERATION FOUNDATION (KR)
International Classes:
A61K38/16; A23L33/18; G01N33/50; G01N33/536
Foreign References:
| US20150086636A1 | 2015-03-26 |
Other References:
AHMAD, S. ET AL.: "Matrix Gla Protein: An Extracellular Matrix Protein Regulates Myostatin Expression in the Muscle Developmental Program", LIFE SCIENCES, ELECTRONIC, vol. 172, 21 December 2016 (2016-12-21), pages 55 - 63, XP055505259
DATABASE Protein [O] 26 February 2014 (2014-02-26), "Matrix Gla Protein Precursor [Mus musculus]", XP055505263, Database accession no. NP_032623.1
DATABASE Protein [O] 10 January 2013 (2013-01-10), "Chain A, Growth/differentiation Factor 8", XP055505442, Database accession no. 3HH2_A
VELLEMAN, S. G. ET AL.: "Versican, Matrix Gla Protein, and Death-associated Protein Expression Affect Muscle Satellite Cell Proliferation and Differentiation", POULTRY SCIENCE, vol. 91, no. 8, August 2012 (2012-08-01), pages 1964 - 1973, XP055518989
DATABASE Protein [O] 26 February 2014 (2014-02-26), "Matrix Gla Protein Precursor [Mus musculus]", XP055505263, Database accession no. NP_032623.1
DATABASE Protein [O] 10 January 2013 (2013-01-10), "Chain A, Growth/differentiation Factor 8", XP055505442, Database accession no. 3HH2_A
VELLEMAN, S. G. ET AL.: "Versican, Matrix Gla Protein, and Death-associated Protein Expression Affect Muscle Satellite Cell Proliferation and Differentiation", POULTRY SCIENCE, vol. 91, no. 8, August 2012 (2012-08-01), pages 1964 - 1973, XP055518989
Attorney, Agent or Firm:
TAEBAEK INTELLECTUAL PROPERTY LAW FIRM (KR)
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