Title:
COMPOSITION FOR INHIBITING THE ONSET OF ARTERIOSCLEROSIS AND INHIBITION METHOD
Document Type and Number:
WIPO Patent Application WO/2005/115409
Kind Code:
A1
Abstract:
[PROBLEMS] To provide a composition for inhibiting the onset of arteriosclerosis by using a rare sugar D-psicose and an inhibition method. [MEANS FOR SOLVING PROBLEMS] A composition for inhibiting the onset of arteriosclerosis characterized by comprising, as the active ingredient, D-psicose having antiatherogenic effects. The antiatherogenic effects as described above include an effect of inhibiting or lessening the expression of a chemokine or a cytokine relating to arteriosclerosis in vivo and an effect of promoting the expression of a receptor participating in the amelioration of arteriosclerosis without affecting the expression of an arteriosclerosis inducer. This composition is used in the form of a product selected from the group consisting of sweeteners, seasonings, food additives, food materials, foods, drinks, health foods and drinks, drugs, quasi drugs and feeds containing D-psicose and/or its derivative and/or a mixture thereof. A method of inhibiting the onset of arteriosclerosis by using the above composition.
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Inventors:
TOKUDA MASAAKI (JP)
MURAO KOUJI (JP)
ISHIDA TOSHIHIKO (JP)
IZUMORI KEN (JP)
MURAO KOUJI (JP)
ISHIDA TOSHIHIKO (JP)
IZUMORI KEN (JP)
Application Number:
PCT/JP2005/009690
Publication Date:
December 08, 2005
Filing Date:
May 26, 2005
Export Citation:
Assignee:
UNIV KAGAWA NAT UNIV CORP (JP)
TOKUDA MASAAKI (JP)
MURAO KOUJI (JP)
ISHIDA TOSHIHIKO (JP)
IZUMORI KEN (JP)
TOKUDA MASAAKI (JP)
MURAO KOUJI (JP)
ISHIDA TOSHIHIKO (JP)
IZUMORI KEN (JP)
International Classes:
A23K1/16; A23L1/30; A61K31/7004; A61P9/10; A61P43/00; C07H3/02; (IPC1-7): A61K31/7004; A23K1/16; A23L1/30; A61P9/10; A61P43/00; C07H3/02
Domestic Patent References:
| WO2003097820A1 | 2003-11-27 | |||
| WO2005020721A1 | 2005-03-10 | |||
| WO2003097820A1 | 2003-11-27 |
Other References:
See also references of EP 1757297A4
KONDRATENKO K; STEINBERG D; QUENQUENBERGER O: "Characterization of CLA-1, Human Homologue of Rodent Scavenger Receptor B1 as Receptor for HDL and apoptotic thymocyte", J BIOL CHEM, vol. 272, 1997, pages 17551 - 17557
MURAO K ET AL.: "Hepatocyte Nuclear Factor 4 Inhibits Activity of Site A from the Rat Apolipoprotein A1 gene", BIOCHEMISTRY, vol. 36, 1997, pages 301 - 306
TANGIRARA R; MURAO K; QUENQUENBERGER O: "Regulation of the monocyte chemotactic protein-1 receptor expression by cytokines", J BIOL CHEM, vol. 272, 1997, pages 8050 - 8056
TALL AR: "Plasma high density lipoproteins. Metabolism and relationship to atherogenesis", J CLIN INVEST, vol. 86, 1990, pages 379 - 384
STEINBERG D.: "Low density lipoprotein oxidation and its pathobiological significance", J BIOL CHEM, vol. 272, 1997, pages 20963 - 20966
GRIFFIN E ET AL.: "A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation", NAT MED, vol. 7, 2001, pages 840 - 846
MATSUO T ET AL.: "Less Body Fat Accumulation with D-Psicose Diet versus D-Fructose Diet", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 30, 2001, pages 55 - 65
KONDRATENKO K; STEINBERG D; QUENQUENBERGER O: "Characterization of CLA-1, Human Homologue of Rodent Scavenger Receptor B1 as Receptor for HDL and apoptotic thymocyte", J BIOL CHEM, vol. 272, 1997, pages 17551 - 17557
MURAO K ET AL.: "Hepatocyte Nuclear Factor 4 Inhibits Activity of Site A from the Rat Apolipoprotein A1 gene", BIOCHEMISTRY, vol. 36, 1997, pages 301 - 306
TANGIRARA R; MURAO K; QUENQUENBERGER O: "Regulation of the monocyte chemotactic protein-1 receptor expression by cytokines", J BIOL CHEM, vol. 272, 1997, pages 8050 - 8056
TALL AR: "Plasma high density lipoproteins. Metabolism and relationship to atherogenesis", J CLIN INVEST, vol. 86, 1990, pages 379 - 384
STEINBERG D.: "Low density lipoprotein oxidation and its pathobiological significance", J BIOL CHEM, vol. 272, 1997, pages 20963 - 20966
GRIFFIN E ET AL.: "A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation", NAT MED, vol. 7, 2001, pages 840 - 846
MATSUO T ET AL.: "Less Body Fat Accumulation with D-Psicose Diet versus D-Fructose Diet", JOURNAL OF CLINICAL BIOCHEMISTRY AND NUTRITION, vol. 30, 2001, pages 55 - 65
Attorney, Agent or Firm:
Sudo, Asako (Kajinocho Koganei-shi, Tokyo 02, JP)
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