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Title:
COMPOSITION FOR INHIBITING PRODUCTION OF IL-8 FROM ACTIVATED T CELL
Document Type and Number:
WIPO Patent Application WO/2018/221562
Kind Code:
A1
Abstract:
According to the present invention, it is found that dopamine D2-like receptor agonists acts on a dopamine D2-like receptor in an activated Th cell and thereby inhibits the production of Interleukin-8 (IL-8).

Inventors:
MATSUSHITA SHO (JP)
KAWANO MASAAKI (JP)
TAKAGI RIE (JP)
SATO TSUYOSHI (JP)
Application Number:
JP2018/020696
Publication Date:
December 06, 2018
Filing Date:
May 30, 2018
Export Citation:
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Assignee:
IMMNO INC (JP)
UNIV SAITAMA MEDICAL (JP)
International Classes:
A61K45/00; A61K31/192; A61K31/353; A61K31/4045; A61K31/428; A61K31/7024; A61P1/00; A61P1/02; A61P7/00; A61P11/00; A61P17/06; A61P29/00; A61P43/00; C07D209/34; C07D277/82; C07H13/08
Foreign References:
JP2010024198A2010-02-04
JP2010111581A2010-05-20
JP2010517992A2010-05-27
JP2011006341A2011-01-13
Other References:
NAKAGOME, KAZUYUKI ET AL.: "Neutrophilic inflammation in severe asthma ", INT. ARCH. ALLERGY IMMUNOL., vol. 158, no. suppl. 1, 2012, pages 96 - 102, XP008165227
KIM, IN-BAE ET AL.: "Inhibition of IL-8 Production by Green Tea Polyphenols in Human Nasal Fibroblasts and A549 Epithelial Cells", BIOL. PHARM. BULL., vol. 29, no. 6, 2006, pages 1120 - 1125, XP055636645
TSANG, MIRANDA SM ET AL.: "Anti-inflammatory activities of Pentaherbs formula", PROCEEDINGS OF THE JAPANESE SOCIETY FOR IMMUNOLOGY, vol. 44, 1-C-W3-14-P, 2015, pages 38
PARRADO, ANDREA CECILIA: "Dopamine Agonists Upregulate IL-6 and IL-8 Production in Human Keratinocytes", NEUROIMMUNOMODULATION, vol. 19, 2012, pages 359 - 366, XP055636663, DOI: 10.1159/000342140
MATSUYUMA, TUSHIYUKI ET AL: "Production of IL-8 by T-cell and dopamine signal (non-official translation)", ALLERGY, vol. 66, no. 4/5, 15 May 2017 (2017-05-15), pages 689
MATSUYAMA, TOSHIYUKI ET AL.: "Inhibition of neutrophilic inflammation by dopamine D2-type receptor agonist (non-official translation)", THE 36TH PROGRAMS AND ABSTRACTS OF THE JAPAN SOCIETY OF IMMUNOLOGY & ALLERGOLOGY IN OTOLARYNGOLOGY, 13 March 2018 (2018-03-13), pages 86
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
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