Title:
COMPOSITION FOR MAINTAINING PLATELET FUNCTION
Document Type and Number:
WIPO Patent Application WO/2012/036257
Kind Code:
A1
Abstract:
Provided is a composition for maintaining platelet function that has as the active ingredient a compound represented by general formula (I) [in the formula: X indicates a phenylene group; Y indicates a hydrogen atom or -(CH2)mR1; m indicates any integer from 0 to 4; R1 indicates -NR5COR2, -NR5SO2R2, or -NR3R4; R2 indicates a C1-C6 alkyl group, an aryl group, a C1-C6 alkoxy group, or the like; R3 and R4 indicate a C1-C6 alkyl group or the like; R5 indicates a hydrogen atom, a C1-C6 alkyl group, or the like; and Z indicates a hydrogen atom or a C1-C6 alkyl group] or a salt thereof, or a solvate of the compound or the salt thereof.
Inventors:
ETO KOJI (JP)
OHNISHI RYOKO (JP)
NAKAUCHI HIROMITSU (JP)
MURATA TAKAHIKO (JP)
OHNISHI RYOKO (JP)
NAKAUCHI HIROMITSU (JP)
MURATA TAKAHIKO (JP)
Application Number:
PCT/JP2011/071190
Publication Date:
March 22, 2012
Filing Date:
September 16, 2011
Export Citation:
Assignee:
UNIV TOKYO (JP)
KAKEN PHARMA CO LTD (JP)
ETO KOJI (JP)
OHNISHI RYOKO (JP)
NAKAUCHI HIROMITSU (JP)
MURATA TAKAHIKO (JP)
KAKEN PHARMA CO LTD (JP)
ETO KOJI (JP)
OHNISHI RYOKO (JP)
NAKAUCHI HIROMITSU (JP)
MURATA TAKAHIKO (JP)
International Classes:
C12N5/073; A61K35/14; A61K47/20; A61K47/22; C12N1/00; C12N5/10; A61K39/00; C07C317/28
Domestic Patent References:
| WO2008041370A1 | 2008-04-10 | |||
| WO2009122747A1 | 2009-10-08 | |||
| WO2009119105A1 | 2009-10-01 |
Foreign References:
| JP2002535392A | 2002-10-22 | |||
| JP2005501087A | 2005-01-13 | |||
| JP2007161686A | 2007-06-28 | |||
| JP2009513601A | 2009-04-02 |
Other References:
HIROYUKI ETO ET AL.: "Saisei Iryo no Saibo Source 3 ES Saibo Yurai Kesshoban", BIOMEDICINE & THERAPEUTICS, vol. 43, no. 6, 2009, pages 21 - 26, XP008168096
MUSSO D.L. ET AL.: "N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1 isobutyl substitution", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 2147 - 2151, XP055082834
BERGMEIER ET AL., CIRCULATION RESEARCH, vol. 95, 2004, pages 660 - 670
BERGMEIER ET AL., BLOOD, vol. 102, 2003, pages 4229 - 4235
PETERSON ET AL., CARDIOVASC. RES., vol. 69, 2006, pages 677 - 687
SKIPPER ET AL., CANCER RES., vol. 40, 1980, pages 4704 - 4708
ETO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 12819 - 12824
ROBERT ET AL.: "Glycoprotein Ibalpha receptor instability is associated with loss of quality of platelets produced in culture", STEM CELLS AND DEVELOPMENT, 26 May 2010 (2010-05-26)
FUJIMOTO ET AL., BLOOD, vol. 102, 2003, pages 4044 - 4051
HIROYAMA ET AL., EXP. HEMATOL., vol. 34, 2006, pages 760 - 769
GAUR ET AL., J THROMB HAEMOST., vol. 4, 2005, pages 436 - 442
MOSS ET AL., NATURE, vol. 385, 1997, pages 733 - 736
CAESCU ET AL., BIOCHEMICAL J., vol. 424, 2009, pages 79 - 88
BENDER ET AL.: "Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases", BLOOD, 19 July 2010 (2010-07-19)
MATTHIAS C. ET AL.: "TRANSFUSION MEDICINE", BLOOD, vol. 115, no. 9, 4 March 2010 (2010-03-04), pages 1835 - 1842
RUGGERI ZM., NATURE MEDICINE, vol. 8, no. 11, November 2002 (2002-11-01), pages 1227 - 1234
TAKIZAWA ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 1, January 2010 (2010-01-01), pages 179 - 190
See also references of EP 2617812A4
MUSSO D.L. ET AL.: "N-Hydroxyformamide peptidomimetics as TACE/Matrix metalloprotease inhibitors: oral activity via P1 isobutyl substitution", BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, vol. 11, 2001, pages 2147 - 2151, XP055082834
BERGMEIER ET AL., CIRCULATION RESEARCH, vol. 95, 2004, pages 660 - 670
BERGMEIER ET AL., BLOOD, vol. 102, 2003, pages 4229 - 4235
PETERSON ET AL., CARDIOVASC. RES., vol. 69, 2006, pages 677 - 687
SKIPPER ET AL., CANCER RES., vol. 40, 1980, pages 4704 - 4708
ETO ET AL., PROC. NATL. ACAD. SCI. USA, vol. 99, 2002, pages 12819 - 12824
ROBERT ET AL.: "Glycoprotein Ibalpha receptor instability is associated with loss of quality of platelets produced in culture", STEM CELLS AND DEVELOPMENT, 26 May 2010 (2010-05-26)
FUJIMOTO ET AL., BLOOD, vol. 102, 2003, pages 4044 - 4051
HIROYAMA ET AL., EXP. HEMATOL., vol. 34, 2006, pages 760 - 769
GAUR ET AL., J THROMB HAEMOST., vol. 4, 2005, pages 436 - 442
MOSS ET AL., NATURE, vol. 385, 1997, pages 733 - 736
CAESCU ET AL., BIOCHEMICAL J., vol. 424, 2009, pages 79 - 88
BENDER ET AL.: "Differentially regulated GPVI ectodomain shedding by multiple platelet-expressed proteinases", BLOOD, 19 July 2010 (2010-07-19)
MATTHIAS C. ET AL.: "TRANSFUSION MEDICINE", BLOOD, vol. 115, no. 9, 4 March 2010 (2010-03-04), pages 1835 - 1842
RUGGERI ZM., NATURE MEDICINE, vol. 8, no. 11, November 2002 (2002-11-01), pages 1227 - 1234
TAKIZAWA ET AL., THE JOURNAL OF CLINICAL INVESTIGATION, vol. 120, no. 1, January 2010 (2010-01-01), pages 179 - 190
See also references of EP 2617812A4
Attorney, Agent or Firm:
CENTCREST IP ATTORNEYS (JP)
Patent business corporation cent Crest international patent firm (JP)
Patent business corporation cent Crest international patent firm (JP)
Download PDF:
Claims:
Previous Patent: N-VINYL LACTAM POLYMER AND METHOD FOR PRODUCING SAME
Next Patent: METHOD AND DEVICE FOR MEASURING SURFACE-HARDENED LAYER
Next Patent: METHOD AND DEVICE FOR MEASURING SURFACE-HARDENED LAYER