Title:
COMPOSITION FOR MAKING MUSCLES FLEXIBLE
Document Type and Number:
WIPO Patent Application WO/2018/066394
Kind Code:
A1
Abstract:
Provided is a composition that improves the flexibility of muscles by oral intake. The composition, which makes muscles flexible by oral intake, comprises an n-3 highly unsaturated fatty acid as an active ingredient. The n-3 highly unsaturated fatty acid is preferably in the form of a free fatty acid, a lower alcohol ester or a glyceride or phospholipid containing the n-3 highly unsaturated fatty acid as a constituting fatty acid. Particular examples thereof include eicosapentaenoic acid, docosapentaenoic acid, docosahexaenoic acid, purified fish oil, purified krill oil and purified microbial oil.
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Inventors:
YANAGIMOTO KENICHI (JP)
HAN LI (JP)
KAWABATA FUMINORI (JP)
HAN LI (JP)
KAWABATA FUMINORI (JP)
Application Number:
PCT/JP2017/034436
Publication Date:
April 12, 2018
Filing Date:
September 25, 2017
Export Citation:
Assignee:
NIPPON SUISAN KAISHA LTD (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
UNIV KYUSHU NAT UNIV CORP (JP)
International Classes:
A61K31/202; A23L33/12; A61K31/232; A61K31/683; A61K35/60; A61K35/612; A61K35/68; A61P21/00
Foreign References:
| JP2004526458A | 2004-09-02 | |||
| JP2005287376A | 2005-10-20 | |||
| JP2014515011A | 2014-06-26 |
Other References:
SMITH, G. I. ET AL.: "Fish oil-derived n-3 PUFA therapy increases muscle mass and function in healthy older adults", AM. J. CLIN. NUTR., vol. 102, no. 1, 2015, pages 115 - 122, XP055398664, DOI: doi:10.3945/ajcn.114.105833
KAWABATA, F. ET AL.: "Supplementation with eicosapentaenoic acid-rich fish oil improves exercise economy and reduces perceived exertion during submaximal steady-state exercise in normal healthy untrained men", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 78, no. 12, 2014, pages 2081 - 2088, XP055398666, DOI: doi:10.1080/09168451.2014.946392
ZEBROWSKA, A. ET AL.: "Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes", EUR. J. SPORT SCI., vol. 15, no. 4, 2015, pages 305 - 314
SIMOPOULOS, A. P.: "Omega-3 fatty acids and athletics", CURR. SPORTS MED. REP., vol. 6, no. 4, 2007, pages 230 - 236
PEOPLES, G. E. ET AL.: "Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model", BR. J. NUTR., vol. III, no. 6, 2014, pages 996 - 1003
NORDEZ, A. ET AL.: "Assessment of muscle hardness changes induced by a submaximal fatiguing isometric contraction", J. ELECTROMYGOR. KINESIOL., vol. 19, no. 3, 2009, pages 484 - 491, XP026031590, DOI: doi:10.1016/j.jelekin.2007.11.005
KAWABATA, F. ET AL.: "Supplementation with eicosapentaenoic acid-rich fish oil improves exercise economy and reduces perceived exertion during submaximal steady-state exercise in normal healthy untrained men", BIOSCI. BIOTECHNOL. BIOCHEM., vol. 78, no. 12, 2014, pages 2081 - 2088, XP055398666, DOI: doi:10.1080/09168451.2014.946392
ZEBROWSKA, A. ET AL.: "Omega-3 fatty acids supplementation improves endothelial function and maximal oxygen uptake in endurance-trained athletes", EUR. J. SPORT SCI., vol. 15, no. 4, 2015, pages 305 - 314
SIMOPOULOS, A. P.: "Omega-3 fatty acids and athletics", CURR. SPORTS MED. REP., vol. 6, no. 4, 2007, pages 230 - 236
PEOPLES, G. E. ET AL.: "Long-chain n-3 DHA reduces the extent of skeletal muscle fatigue in the rat in vivo hindlimb model", BR. J. NUTR., vol. III, no. 6, 2014, pages 996 - 1003
NORDEZ, A. ET AL.: "Assessment of muscle hardness changes induced by a submaximal fatiguing isometric contraction", J. ELECTROMYGOR. KINESIOL., vol. 19, no. 3, 2009, pages 484 - 491, XP026031590, DOI: doi:10.1016/j.jelekin.2007.11.005
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