Title:
COMPOSITION AND METHOD FOR DIAGNOSING AND PREDICTING BREAST CANCER BONE METASTASES
Document Type and Number:
WIPO Patent Application WO/2019/095541
Kind Code:
A1
Abstract:
Provided are a composition and method for diagnosing and predicting breast cancer bone metastases. At present, radionuclide bone scans (ECT), computed tomography (CT), magnetic resonance imaging (MRI), positron emission tomography-computed tomography (PET-CT), and osseous tissue biopsy are gold standards for the discovery and diagnosis of breast cancer bone metastases. However, these methods all have different deficiencies, such as high examination costs, an increase in burden of patents due to interventional diagnosis, and an increase in pressure on routine examination of bone metastases in breast cancer patients. By studying and comparing the differences in gene expression in serum of breast cancer patients with and without bone metastases, gene markers that can be used for diagnosing and predicting different molecular subtypes of breast cancer bone metastases have been discovered and verified, and therefore, a composition and method capable of quickly diagnosing and predicting different molecular subtypes of breast cancer bone metastases by means of blood can be provided.
Inventors:
LI YIJIAN (CN)
XUE SHOUHAI (CN)
XUE SHOUHAI (CN)
Application Number:
PCT/CN2018/072269
Publication Date:
May 23, 2019
Filing Date:
January 11, 2018
Export Citation:
Assignee:
LI YIJIAN (CN)
XUE SHOUHAI (CN)
XUE SHOUHAI (CN)
International Classes:
C12Q1/6886
Other References:
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ZHAN, Y.H. ET AL.: "Increased Expression of SUMO1P3 Predicts Poor Prognosis and Promotes Tumor Growth and Metastasis in Bladder Cancer", ONCOTARGET, vol. 7, no. 13, 19 January 2016 (2016-01-19), pages 16038 - 16048, XP055609564
LI, J. ET AL.: "Regulation of LncRNA and Its Role in Cancer Metastasis", ONCOLOGY RESEARCH., vol. 23, no. 5, 13 April 2016 (2016-04-13), pages 205 - 217, XP055609566
"Expression Characteristic and Prognostic Value of Long Non-Coding RNA LINC00467 in Colorectal Cancer", CHINESE JOURNAL OF CANCER PREVENTION AND TREATMENT, vol. 24, no. 17, 30 September 2017 (2017-09-30), pages 1206 - 1213
"Expression of LncRNA-AL049452 in the Tissue of Colorectal Cancer and Its Clinical Significance", JOURNAL OF WENZHOU MEDICAL UNIVERSITY, vol. 47, no. 8, 31 August 2017 (2017-08-31), pages 566 - 570
"Role of Long Non-Coding RNA AK043773 in Adipocyte Differentiation", BIOTECHNOLOGY BULLETIN, vol. 33, no. 12, 23 October 2017 (2017-10-23), pages 156 - 161
JIANG, Z.H. ET AL.: "Kruppel-Like Factor 7 is a Marker of Aggressive Gastric Cancer and Poor Prognosis", CELLULAR PHYSIOLOGY AND BIOCHEMISTRY, vol. 43, 5 October 2017 (2017-10-05), pages 1090 - 1099, XP055609567
ZENG, LI ET AL.: "The Relationship Between the Expression of LncRNA EXOC7 and the Prognosis of Patients with Small Cell Lung Cancer", TUMOR, vol. 37, 31 March 2017 (2017-03-31), pages 269 - 280
WANG, Y.L. ET AL.: "Combined Inhibition of EGFR and C-ABL Suppresses the Growth of Triple-Negative Breast Cancer Growth through Inhibition of HOTAIR", ONCOTARGET, vol. 6, no. 13, 10 March 2015 (2015-03-10), pages 11150 - 11161, XP055609568
CHEN, A.S. ET AL.: "LIMT is a Novel Metastasis Inhibiting Lncrna Suppressed by EGF and Downregulated in Aggressive Breast Cancer", EMBO MOLECULAR MEDICINE., vol. 8, no. 9, 1 August 2016 (2016-08-01), pages 1052 - 1064, XP055609571
QU YANLIN ET AL.: "Advances in the study of LncRNAs of pathogenic microorganisms", JOURNAL OF PATHOGEN BIOLOGY, vol. 10, no. 1, 31 January 2015 (2015-01-31), pages 75 - 77
"Clinical Characteristics and Prognosis of Different Subtypes of Breast Cancer with Bone Metastasis", JOURNAL OF XI'AN JIAOTONG UNIVERSITY (MEDICAL SCIENCES, vol. 38, no. 5, 30 September 2017 (2017-09-30), pages 740 - 743
Attorney, Agent or Firm:
NANJING HUISHENG PATENT & TRADEMARK FIRM (GENERAL PARTNERSHIP) et al. (CN)
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