Title:
COMPOSITION AND METHOD FOR INHIBITING AMYLOID BETA ACCUMULATION AND/OR AGGREGATION
Document Type and Number:
WIPO Patent Application WO/2020/117031
Kind Code:
A2
Abstract:
Disclosed herein is an amyloid β accumulation and/or aggregation inhibitor. A technique for inhibiting amyloid β accumulation and/or aggregation by concurrently introducing Nurr1 and Foxa2 genes and introducing the co-expression of the genes is also provided. When used, the composition can be applied to the prevention or treatment of a neurodegenerative disease caused by amyloid β accumulation and/or aggregation, such as Alzheimer's disease.
Inventors:
LEE SANG HUN (KR)
SONG JAE JIN (KR)
YANG YUN SEON (KR)
KIM TAE GYUN (KR)
SONG JAE JIN (KR)
YANG YUN SEON (KR)
KIM TAE GYUN (KR)
Application Number:
PCT/KR2020/003439
Publication Date:
June 11, 2020
Filing Date:
March 12, 2020
Export Citation:
Assignee:
INNOPEUTICS CORP (KR)
International Classes:
A61K35/30
Other References:
SAMBROOKFRITSCHMANIATIS: "Molecular Cloning, A laboratory Manua", 1989, COLD SPRING HARBOR LABORATORY PRESS
"Molecular Biology", 1992, JOHN WILEY AND SONS
SAURA J: "Microglia in astroglial cultures: a cautionary note", J NEUROINFLAMMATION, vol. 4, 2007, pages 26, XP021037913
HEINRICH CGASCON SMASSERDOTTI GLEPIER ASANCHEZ RSIMON-EBERT TSCHROEDER TGOTZ MBERNINGER B: "Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex", NAT PROTOC, vol. 6, 2011, pages 214 - 228
BLASI EBARLUZZI RBOCCHINI VMAZZOLLA RBISTONI F: "Immortalization of murine microglia by a v-raf/v-myc carrying retrovirus", J NEUROIMMUNOL, vol. 27, 1990, pages 229 - 237
YANG, C. N.WU, M. F.LIU, C. C.JUNG, W. H.CHANG, Y. C.LEE, W. P.CHAN, C. C.: "Differential protective effects of connective tissue growth factor against Abeta neurotoxicity on neurons and glia", HUM MOL GENET, vol. 26, no. 20, 2017, pages 3909 - 3921
RIES, M.SASTRE, M: "Mechanisms of Abeta Clearance and Degradation by Glia", FRONT AGING NEUROSCI, vol. 8, 2016, pages 160
CZIRR, E. ET AL.: "Microglial complement receptor 3 regulates brain Abeta levels through secreted proteolytic activity", J EXP MED, vol. 214, no. 4, 2017, pages 1081 - 1092
HONG, S.BEJA-GLASSER, V. F.NFONOYIM, B. M.FROUIN, A.LI, S.RAMAKRISHNAN, S.MERRY K.M.SHI Q.ROSENTHAL A.BARRES B.A.: "Complement and microglia mediate early synapse loss in Alzheimer mouse models", SCIENCE, vol. 352, no. 6286, 2016, pages 712 - 716
SHI, Q. ET AL.: "Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice", SCI TRANSL MED, vol. 9, no. 392, 2017
KANG, S. S. ET AL.: "Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau", J EXP MED, vol. 215, no. 9, 2018, pages 2235 - 2245
VENEGAS, C. ET AL.: "Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer's disease", NATURE, vol. 552, no. 7685, 2017, pages 355 - 361, XP055473472, DOI: 10.1038/nature25158
HENEKA, M. T. ET AL.: "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice", NATURE, vol. 493, no. 7434, 2013, pages 674 - 678, XP055125448, DOI: 10.1038/nature11729
BUSSIAN, T. J. ET AL.: "Clearance of senescent glia prevents tau-dependent pathology and cognitive decline", NATURE, vol. 562, no. 7728, 2018, pages 578 - 582
CHINTA, S. J. ET AL.: "Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease", CELL REP, vol. 22, no. 4, 2018, pages 930 - 940
BHAT, R. ET AL.: "Astrocyte senescence as a component of Alzheimer's disease", PLOS ONE, vol. 7, no. 9, 2012, pages e45069
See also references of EP 3972616A4
"Molecular Biology", 1992, JOHN WILEY AND SONS
SAURA J: "Microglia in astroglial cultures: a cautionary note", J NEUROINFLAMMATION, vol. 4, 2007, pages 26, XP021037913
HEINRICH CGASCON SMASSERDOTTI GLEPIER ASANCHEZ RSIMON-EBERT TSCHROEDER TGOTZ MBERNINGER B: "Generation of subtype-specific neurons from postnatal astroglia of the mouse cerebral cortex", NAT PROTOC, vol. 6, 2011, pages 214 - 228
BLASI EBARLUZZI RBOCCHINI VMAZZOLLA RBISTONI F: "Immortalization of murine microglia by a v-raf/v-myc carrying retrovirus", J NEUROIMMUNOL, vol. 27, 1990, pages 229 - 237
YANG, C. N.WU, M. F.LIU, C. C.JUNG, W. H.CHANG, Y. C.LEE, W. P.CHAN, C. C.: "Differential protective effects of connective tissue growth factor against Abeta neurotoxicity on neurons and glia", HUM MOL GENET, vol. 26, no. 20, 2017, pages 3909 - 3921
RIES, M.SASTRE, M: "Mechanisms of Abeta Clearance and Degradation by Glia", FRONT AGING NEUROSCI, vol. 8, 2016, pages 160
CZIRR, E. ET AL.: "Microglial complement receptor 3 regulates brain Abeta levels through secreted proteolytic activity", J EXP MED, vol. 214, no. 4, 2017, pages 1081 - 1092
HONG, S.BEJA-GLASSER, V. F.NFONOYIM, B. M.FROUIN, A.LI, S.RAMAKRISHNAN, S.MERRY K.M.SHI Q.ROSENTHAL A.BARRES B.A.: "Complement and microglia mediate early synapse loss in Alzheimer mouse models", SCIENCE, vol. 352, no. 6286, 2016, pages 712 - 716
SHI, Q. ET AL.: "Complement C3 deficiency protects against neurodegeneration in aged plaque-rich APP/PS1 mice", SCI TRANSL MED, vol. 9, no. 392, 2017
KANG, S. S. ET AL.: "Microglial translational profiling reveals a convergent APOE pathway from aging, amyloid, and tau", J EXP MED, vol. 215, no. 9, 2018, pages 2235 - 2245
VENEGAS, C. ET AL.: "Microglia-derived ASC specks cross-seed amyloid-beta in Alzheimer's disease", NATURE, vol. 552, no. 7685, 2017, pages 355 - 361, XP055473472, DOI: 10.1038/nature25158
HENEKA, M. T. ET AL.: "NLRP3 is activated in Alzheimer's disease and contributes to pathology in APP/PS1 mice", NATURE, vol. 493, no. 7434, 2013, pages 674 - 678, XP055125448, DOI: 10.1038/nature11729
BUSSIAN, T. J. ET AL.: "Clearance of senescent glia prevents tau-dependent pathology and cognitive decline", NATURE, vol. 562, no. 7728, 2018, pages 578 - 582
CHINTA, S. J. ET AL.: "Cellular Senescence Is Induced by the Environmental Neurotoxin Paraquat and Contributes to Neuropathology Linked to Parkinson's Disease", CELL REP, vol. 22, no. 4, 2018, pages 930 - 940
BHAT, R. ET AL.: "Astrocyte senescence as a component of Alzheimer's disease", PLOS ONE, vol. 7, no. 9, 2012, pages e45069
See also references of EP 3972616A4
Attorney, Agent or Firm:
YOON, Dae Woong (KR)
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